Variable Cyst Development in Autosomal Dominant Polycystic Kidney Disease: The Biologic Context. (Q38919283)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27493259 AND SRC:MED&resulttype=core&format=json

20 March 2020

review article

1 reference

title

Variable Cyst Development in Autosomal Dominant Polycystic Kidney Disease: The Biologic Context (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27493259 AND SRC:MED&resulttype=core&format=json

autosomal dominant polycystic kidney disease

20 March 2020

main subject

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autosomal dominant polycystic kidney

inferred from title

1 reference

1

1 reference

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20 March 2020

author name string

Hester Happe

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27493259 AND SRC:MED&resulttype=core&format=json

20 March 2020

Dorien J M Peters

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27493259 AND SRC:MED&resulttype=core&format=json

20 March 2020

publication date

4 August 2016

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27493259 AND SRC:MED&resulttype=core&format=json

Journal of the American Society of Nephrology

20 March 2020

published in

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20 March 2020

volume

27

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20 March 2020

issue

12

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20 March 2020

page(s)

3530-3538

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Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease

20 March 2020

cites work

1 reference

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Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease.

17 June 2018

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A mild reduction of food intake slows disease progression in an orthologous mouse model of polycystic kidney disease

17 June 2018

1 reference

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Food Restriction Ameliorates the Development of Polycystic Kidney Disease

17 June 2018

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2-Deoxy-d-Glucose Ameliorates PKD Progression

17 June 2018

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Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease

17 June 2018

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An mTOR kinase inhibitor slows disease progression in a rat model of polycystic kidney disease

17 June 2018

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M1 and M2 macrophages: the chicken and the egg of immunity

17 June 2018

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Translational research in ADPKD: lessons from animal models

17 June 2018

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Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

17 June 2018

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An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2.

17 June 2018

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Tubular obstruction leads to progressive proximal tubular injury and atubular glomeruli in polycystic kidney disease

17 June 2018

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Rationale and design of the DIPAK 1 study: a randomized controlled clinical trial assessing the efficacy of lanreotide to Halt disease progression in autosomal dominant polycystic kidney disease

17 June 2018

1 reference

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Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease

17 June 2018

1 reference

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Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.

17 June 2018

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Type of PKD1 mutation influences renal outcome in ADPKD.

17 June 2018

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Macrophages promote polycystic kidney disease progression

17 June 2018

1 reference

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Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption

17 June 2018

1 reference

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Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

17 June 2018

1 reference

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Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity

17 June 2018

1 reference

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Folate-conjugated rapamycin slows progression of polycystic kidney disease

17 June 2018

1 reference

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Detected renal cysts are tips of the iceberg in adults with ADPKD.

17 June 2018

1 reference

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Dose-dependent effects of sirolimus on mTOR signaling and polycystic kidney disease

17 June 2018

1 reference

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Mutations in multiple PKD genes may explain early and severe polycystic kidney disease

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118495

Macrophages promote cyst growth in polycystic kidney disease

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118495

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

17 June 2018

1 reference

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Polycystin-1 regulates STAT activity by a dual mechanism

17 June 2018

1 reference

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Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis.

17 June 2018

1 reference

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Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis

17 June 2018

1 reference

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MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein

17 June 2018

1 reference

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Genetic variation of DKK3 may modify renal disease severity in ADPKD.

17 June 2018

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Incompletely penetrant PKD1 alleles mimic the renal manifestations of ARPKD.

17 June 2018

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Evidence of extraordinary growth in the progressive enlargement of renal cysts

17 June 2018

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Pkd1 haploinsufficiency increases renal damage and induces microcyst formation following ischemia/reperfusion

17 June 2018

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Pkd2 dosage influences cellular repair responses following ischemia-reperfusion injury

17 June 2018

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Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways

17 June 2018

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Renal injury is a third hit promoting rapid development of adult polycystic kidney disease

17 June 2018

1 reference

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Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter

17 June 2018

1 reference

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Src inhibition ameliorates polycystic kidney disease

17 June 2018

1 reference

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Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.

17 June 2018

1 reference

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Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure.

17 June 2018

1 reference

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A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

17 June 2018

1 reference

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PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice

17 June 2018

1 reference

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Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease

17 June 2018

1 reference

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Overexpression of PKD1 causes polycystic kidney disease

17 June 2018

1 reference

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Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1

17 June 2018

1 reference

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The polycystic kidney disease-1 promoter is a target of the beta-catenin/T-cell factor pathway

17 June 2018

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Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis

17 June 2018

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Cardiac defects and renal failure in mice with targeted mutations in Pkd2

17 June 2018

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Generalized lacZ expression with the ROSA26 Cre reporter strain

17 June 2018

1 reference

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Do human chromosomal bands 16p13 and 22q11-13 share ancestral origins?

17 June 2018

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Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation

17 June 2018

1 reference

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PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

17 June 2018

1 reference

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Autosomal dominant polycystic kidney disease--more than a renal disease

17 June 2018

1 reference

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Diet and polycystic kidney disease: A pilot intervention study.

17 June 2018

1 reference

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Characterization of the polycystic kidney disease 2 gene promoter.

22 August 2018

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Comprehensive gene expression changes associated with mouse postnatal kidney development

22 August 2018

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Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model.

22 August 2018

1 reference

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Lanreotide reduces the volume of polycystic liver: a randomized, double-blind, placebo-controlled trial.

22 August 2018

1 reference

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Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease

22 August 2018

1 reference

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Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice

22 August 2018

1 reference

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A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype

22 August 2018

1 reference

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The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118495

The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. The European Polycystic Kidney Disease Consortium

22 August 2018

1 reference

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Cyst formation and growth in autosomal dominant polycystic kidney disease

22 August 2018

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12 December 2020

More adverse renal prognosis of autosomal dominant polycystic kidney disease in families with primary hypertension

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12 December 2020

Cyst expansion and regression in a mouse model of polycystic kidney disease

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12 December 2020

Autosomal dominant polycystic kidney disease coexisting with cystic fibrosis

1 reference

12 December 2020

Somatic PKD2 mutations in individual kidney and liver cysts support a "two-hit" model of cystogenesis in type 2 autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Neonatal onset autosomal dominant polycystic kidney disease (ADPKD) in a patient homozygous for aPKD2missense mutation due to uniparental disomy

1 reference

12 December 2020

Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model

1 reference

12 December 2020

Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease

1 reference

12 December 2020

Common regulatory elements in the polycystic kidney disease 1 and 2 promoter regions

1 reference

12 December 2020

Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease

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12 December 2020

Identifiers

DOI

10.1681/ASN.2016040425

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27493259 AND SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27493259 AND SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

27493259

1 reference