Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages. (Q38917897)

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28 February 2020

title

Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages (English)

1 reference

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28 February 2020

main subject

macrophage

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hepatocellular carcinoma

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8

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28 February 2020

author name string

Wenjiang Yan

1

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28 February 2020

Xiao Liu

2

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28 February 2020

Hongxin Ma

3

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28 February 2020

Hualin Zhang

4

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28 February 2020

Xiaojia Song

5

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28 February 2020

Lifen Gao

6

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28 February 2020

Xiaohong Liang

7

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28 February 2020

language of work or name

English

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publication date

21 January 2015

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28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25608525 AND SRC:MED&resulttype=core&format=json

28 February 2020

volume

64

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28 February 2020

issue

10

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28 February 2020

page(s)

1593-1604

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Hepatocellular carcinoma: epidemiology, surveillance, and diagnosis

28 February 2020

cites work

1 reference

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Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

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The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor-associated macrophages

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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

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IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men.

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Alternatively activated macrophages during parasite infections

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Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

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Coexpression of Tim-3 and PD-1 identifies a CD8 T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

21 January 2018

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Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.

21 January 2018

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Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

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Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

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Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

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Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8 T cell dysfunction in melanoma patients

21 January 2018

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Tim-3 expression defines regulatory T cells in human tumors

21 January 2018

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Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma.

21 January 2018

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T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner

21 January 2018

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T cell Ig mucin-3 promotes homeostasis of sepsis by negatively regulating the TLR response.

21 January 2018

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Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

21 January 2018

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Human pregnancy up-regulates Tim-3 in innate immune cells for systemic immunity.

21 January 2018

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Tumour-educated macrophages promote tumour progression and metastasis

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TGF-β in progression of liver disease

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Transcriptional regulation of macrophage polarization: enabling diversity with identity

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The role of tumor-associated macrophage in tumor progression

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21 January 2018

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Transforming growth factor beta (TGF-beta) and inflammation in cancer

21 January 2018

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Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation.

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10.1136/GUTJNL-2014-307671

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25608525 AND SRC:MED&resulttype=core&format=json

28 February 2020

1 reference