Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy (Q38909313)

7 September 2017

title

Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy (English)

1 reference

7 September 2017

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25684137 AND SRC:MED&resulttype=core&format=json

2 June 2020

Anette Weyergang

8

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2 June 2020

3

K Berg

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2 June 2020

author name string

M B Berstad

1

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2 June 2020

L H Cheung

2

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2 June 2020

Q Peng

4

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2 June 2020

A S V Fremstedal

5

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2 June 2020

M G Rosenblum

7

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2 June 2020

language of work or name

English

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publication date

16 February 2015

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7 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25684137 AND SRC:MED&resulttype=core&format=json

2 June 2020

volume

34

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2 June 2020

issue

44

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2 June 2020

page(s)

5582-5592

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Mechanisms of acquired resistance to targeted cancer therapies.

2 June 2020

cites work

1 reference

Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules

21 January 2018

1 reference

Photochemical internalization of tumor-targeted protein toxins.

21 January 2018

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Site-specific drug delivery by photochemical internalization enhances the antitumor effect of bleomycin

21 January 2018

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Convergent Potency of Internalized Gelonin Immunotoxins across Varied Cell Lines, Antigens, and Targeting Moieties

21 January 2018

1 reference

Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization.

21 January 2018

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Ribosome-inactivating proteins from plants

21 January 2018

1 reference

Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation

21 January 2018

1 reference

Multi-modality therapeutics with potent anti-tumor effects: photochemical internalization enhances delivery of the fusion toxin scFvMEL/rGel

21 January 2018

1 reference

Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF(121)/rGel fusion toxin.

21 January 2018

1 reference

Photochemical activation of the recombinant HER2-targeted fusion toxin MH3-B1/rGel; Impact of HER2 expression on treatment outcome.

21 January 2018

1 reference

Structural basis for inhibition of the epidermal growth factor receptor by cetuximab

21 January 2018

1 reference

Cell death and growth arrest in response to photodynamic therapy with membrane-bound photosensitizers

21 January 2018

1 reference

Assessing autophagy in the context of photodynamic therapy

21 January 2018

1 reference

Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature

21 January 2018

1 reference

EGFR antagonists in cancer treatment

21 January 2018

1 reference

Immunotoxin treatment of cancer

21 January 2018

1 reference

In vitro and in vivo inhibition of epidermal growth factor receptor-tyrosine kinase pathway by photodynamic therapy

21 January 2018

1 reference

Y1068 phosphorylation is the most sensitive target of disulfonated tetraphenylporphyrin-based photodynamic therapy on epidermal growth factor receptor.

21 January 2018

1 reference

Sustained ERK [corrected] inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy.

21 January 2018

1 reference

Antitumor activity of fibroblast growth factor receptor 3-specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis

21 January 2018

1 reference

Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells

21 January 2018

1 reference

In vitro and in vivo anti-tumor activities of anti-EGFR single-chain variable fragment fused with recombinant gelonin toxin

21 January 2018

1 reference

Construction and characterization of novel, recombinant immunotoxins targeting the Her2/neu oncogene product: in vitro and in vivo studies

21 January 2018

1 reference

Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity

21 January 2018

1 reference

Photochemical internalization of bleomycin is superior to photodynamic therapy due to the therapeutic effect in the tumor periphery

21 January 2018

1 reference

Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors

21 January 2018

1 reference

Vascular endothelial cells as targets for photochemical internalization (PCI).

21 January 2018

1 reference

Squamous cell carcinoma of the head and neck: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

21 January 2018

1 reference

The quest to overcome resistance to EGFR-targeted therapies in cancer

21 January 2018

1 reference

Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells.

21 January 2018

1 reference

Crystal structure of an isoleucine-zipper trimer

21 January 2018

1 reference

In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors

21 January 2018

1 reference

Photodynamic therapy with an endocytically located photosensitizer cause a rapid activation of the mitogen-activated protein kinases extracellular signal-regulated kinase, p38, and c-Jun NH2 terminal kinase with opposing effects on cell survival

21 January 2018

1 reference

In vivo documentation of photochemical internalization, a novel approach to site specific cancer therapy

21 January 2018

1 reference

Amino acid sequence analysis, gene construction, cloning, and expression of gelonin, a toxin derived from Gelonium multiflorum

31 March 2020

1 reference

Abrogation of head and neck squamous cell carcinoma growth by epidermal growth factor receptor ligand fused to pseudomonas exotoxin transforming growth factor alpha-PE38

31 March 2020

1 reference

Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization

31 March 2020

1 reference

Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells

31 March 2020

1 reference

Photochemical internalisation increases the cytotoxic effect of the immunotoxin MOC31-gelonin

31 March 2020

1 reference

Transforming growth factor-alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE38) treatment of subcutaneous and intracranial human glioma and medulloblastoma xenografts in athymic mice.

31 March 2020

1 reference

12 December 2020

Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A

1 reference

12 December 2020

Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor

1 reference

12 December 2020

Mechanisms underlying resistance to cetuximab in the HNSCC cell line: role of AKT inhibition in bypassing this resistance

1 reference

12 December 2020

Interstitial diphtheria toxin-epidermal growth factor fusion protein therapy produces regressions of subcutaneous human glioblastoma multiforme tumors in athymic nude mice.

1 reference

12 December 2020

Photochemical internalization: a novel technology for delivery of macromolecules into cytosol

1 reference

12 December 2020

Recombinant anti-EGFR immunotoxin 425(scFv)-ETA' demonstrates anti-tumor activity against disseminated human pancreatic cancer in nude mice.

1 reference

12 December 2020

Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer.

1 reference

12 December 2020

Biology and reversal of aerodigestive tract carcinogenesis

1 reference

12 December 2020

Microtiter-based assay for evaluating the biological activity of ribosome-inactivating proteins

1 reference

12 December 2020

Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma.

1 reference

12 December 2020

Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas

1 reference

12 December 2020