Combined treatment strategies for microtubule stabilizing agent-resistant tumors (Q38908225)

7 September 2017

title

Combined treatment strategies for microtubule stabilizing agent-resistant tumors (English)

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7 September 2017

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ChEBI release 2020-05-28

ChEBI ID

31550

author name string

Angela Broggini-Tenzer

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7 September 2017

Ashish Sharma

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Katarzyna J Nytko

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Sabine Bender

4

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Van Vuong

5

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Katrin Orlowski

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Daniel Hug

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Terence O'Reilly

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Martin Pruschy

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7 September 2017

language of work or name

English

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publication date

17 February 2015

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Journal of the National Cancer Institute

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published in

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volume

107

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issue

4

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Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

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cites work

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Taxol binds to cellular microtubules

21 January 2018

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Taxol stabilizes microtubules in mouse fibroblast cells

21 January 2018

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Taxanes for breast cancer: an evidence-based review of randomized phase II and phase III trials

21 January 2018

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Comparison of survival and quality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: results of an Eastern Cooperative Oncology Group trial.

21 January 2018

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Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents

21 January 2018

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Structural insights into microtubule function

21 January 2018

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21 January 2018

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Hypoxia induces class III beta-tubulin gene expression by HIF-1alpha binding to its 3' flanking region

21 January 2018

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Microtubules and resistance to tubulin-binding agents

21 January 2018

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Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes

21 January 2018

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Role of the microenvironment for radiosensitization by patupilone

21 January 2018

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Patupilone induced vascular disruption in orthotopic rodent tumor models detected by magnetic resonance imaging and interstitial fluid pressure

21 January 2018

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Metronomic dosing enhances the anti-angiogenic effect of epothilone B.

21 January 2018

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Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function.

21 January 2018

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The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion

21 January 2018

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Dynamics of tumor hypoxia in response to patupilone and ionizing radiation

21 January 2018

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Regulation of VEGF-expression by patupilone and ionizing radiation in lung adenocarcinoma cells

21 January 2018

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Inhibition of the mammalian target of rapamycin (mTOR) by rapamycin increases chemosensitivity of CaSki cells to paclitaxel

21 January 2018

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A phase 2 study of everolimus combined with trastuzumab and paclitaxel in patients with HER2-overexpressing advanced breast cancer that progressed during prior trastuzumab and taxane therapy

21 January 2018

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Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells

21 January 2018

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Evaluation of the mTOR inhibitor, everolimus, in combination with cytotoxic antitumor agents using human tumor models in vitro and in vivo

21 January 2018

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A phase-1b study of everolimus plus paclitaxel in patients with small-cell lung cancer

21 January 2018

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Enhanced Antitumor Activity with Combining Effect of mTOR Inhibition and Microtubule Stabilization in Hepatocellular Carcinoma

21 January 2018

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Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer

21 January 2018

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Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo.

21 January 2018

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mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor

21 January 2018

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Metronomic chemotherapy in combination with antiangiogenic treatment induces mosaic vascular reduction and tumor growth inhibition in hepatocellular carcinoma xenografts

21 January 2018

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Interaction of immunosuppressive agents rapamycin and its analogue SDZ-RAD with endothelial P-gp

21 January 2018

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Paclitaxel-resistant advanced recurrent breast cancer: a case of partial response due to addition of bevacizumab to paclitaxel therapy: a case report

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1093/JNCI/DJU504

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7 September 2017

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