Neurosteroids for the potential protection of humans against organophosphate toxicity. (Q38906587)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27450921 AND SRC:MED&resulttype=core&format=json

19 March 2020

review article

1 reference

title

Neurosteroids for the potential protection of humans against organophosphate toxicity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27450921 AND SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27450921 AND SRC:MED&resulttype=core&format=json

19 March 2020

author name string

Doodipala Samba Reddy

series ordinal

1

1 reference

7 September 2017

language of work or name

English

0 references

publication date

23 July 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27450921 AND SRC:MED&resulttype=core&format=json

19 March 2020

number of pages

8

1 reference

Annals of the New York Academy of Sciences

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27450921 AND SRC:MED&resulttype=core&format=json

19 March 2020

volume

1378

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27450921 AND SRC:MED&resulttype=core&format=json

19 March 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27450921 AND SRC:MED&resulttype=core&format=json

19 March 2020

page(s)

25-32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27450921 AND SRC:MED&resulttype=core&format=json

Clinical Potential of Neurosteroids for CNS Disorders.

19 March 2020

cites work

1 reference

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Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic δGABA(A) Receptors.

9 September 2017

1 reference

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The pervasive reduction of GABA-mediated synaptic inhibition of principal neurons in the hippocampus during status epilepticus

9 September 2017

1 reference

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Midazolam as an anticonvulsant antidote for organophosphate intoxication--A pharmacotherapeutic appraisal

9 September 2017

1 reference

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Antiseizure Activity of Midazolam in Mice Lacking δ-Subunit Extrasynaptic GABA(A) Receptors

9 September 2017

1 reference

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Perimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity.

9 September 2017

1 reference

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The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302.

9 September 2017

1 reference

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Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.

9 September 2017

1 reference

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Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability

9 September 2017

1 reference

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Neuroactive steroids for the treatment of status epilepticus

9 September 2017

1 reference

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Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis

9 September 2017

1 reference

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Timing of decontamination and treatment in case of percutaneous VX poisoning: a mini review

9 September 2017

1 reference

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Structure-activity relationship and efficacy of pyridinium oximes in the treatment of poisoning with organophosphorus compounds: a review of recent data

9 September 2017

1 reference

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Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy

9 September 2017

1 reference

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Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors

9 September 2017

1 reference

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Neurotoxic effects in patients poisoned with organophosphorus pesticides

9 September 2017

1 reference

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Neurosteroids: endogenous role in the human brain and therapeutic potentials

9 September 2017

1 reference

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The GluK1 (GluR5) Kainate/{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 reduces soman-induced seizures and neuropathology

9 September 2017

1 reference

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The CounterACT Research Network: basic mechanisms and practical applications.

9 September 2017

1 reference

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The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Behavioral sequelae following acute diisopropylfluorophosphate intoxication in rats: comparative effects of atropine and cannabinomimetics

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs

9 September 2017

1 reference

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Subunit-specific trafficking of GABA(A) receptors during status epilepticus

9 September 2017

1 reference

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Neurosteroid modulation of GABAA receptors: molecular determinants and significance in health and disease

9 September 2017

1 reference

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GABA(A) receptor internalization during seizures

9 September 2017

1 reference

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Management of acute organophosphorus pesticide poisoning

9 September 2017

1 reference

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Neurosteroid binding sites on GABA(A) receptors

9 September 2017

1 reference

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Mechanisms of neurosteroid interactions with GABA(A) receptors.

9 September 2017

1 reference

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Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

9 September 2017

1 reference

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Sarin experiences in Japan: acute toxicity and long-term effects

9 September 2017

1 reference

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Increased morbidity and mortality in acute human organophosphate-poisoned patients treated by oximes: a meta-analysis of clinical trials

9 September 2017

1 reference

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Oxime therapy and outcomes in human organophosphate poisoning: an evaluation using meta-analytic techniques

9 September 2017

1 reference

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Complex view on poisoning with nerve agents and organophosphates.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Anticonvulsant activity of androsterone and etiocholanolone.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Status epilepticus increases the intracellular accumulation of GABAA receptors

9 September 2017

1 reference

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Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment

9 September 2017

1 reference

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Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Anticonvulsant activity of the testosterone-derived neurosteroid 3alpha-androstanediol.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Neurosteroids: biochemistry and clinical significance

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself

9 September 2017

1 reference

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Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.

9 September 2017

1 reference

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The neurosteroid 3 alpha, 5 apha-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy

9 September 2017

1 reference

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Organophosphate and carbamate poisoning

9 September 2017

1 reference

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Anticonvulsant activity of neurosteroids: correlation with gamma-aminobutyric acid-evoked chloride current potentiation

9 September 2017

1 reference

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Sarin poisoning in Matsumoto, Japan

9 September 2017

1 reference

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Protection against nerve agent poisoning by a noncompetitive nicotinic antagonist.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Neurosteroids shift partial agonist activation of GABA(A) receptor channels from low- to high-efficacy gating patterns.

9 September 2017

1 reference

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Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit.

14 September 2017

1 reference

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Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action

25 September 2017

1 reference

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Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one

25 September 2017

1 reference

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Effects of sarin on the nervous system of subway workers seven years after the Tokyo subway sarin attack

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Asymptomatic sequelae to acute sarin poisoning in the central and autonomic nervous system 6 months after the Tokyo subway attack

17 June 2018

1 reference

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Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology

17 June 2018

1 reference

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Report on 640 victims of the Tokyo subway sarin attack

17 June 2018

1 reference

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Comparative behavioral characterization of the neuroactive steroids 3α-OH,5α-pregnan-20-one and 3α-OH,5β-pregnan-20-one in rodents

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Chronic Neurological Sequelae of Acute Organophosphate Pesticide Poisoning

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Efficacy of pralidoxime in organophosphorus poisoning: revisiting the controversy in Indian setting

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Syrian gas attack reinforces need for better anti-sarin drugs

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Dual mechanisms diminishing tonic GABAA inhibition of dentate gyrus granule cells in Noda epileptic rats.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Time-dependent reduction in the anticonvulsant effectiveness of diazepam against soman-induced seizures in guinea pigs

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after delivery

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Nicotinic mechanisms contribute to soman-induced symptoms and lethality

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Post-traumatic stress disorder symptoms in victims of Tokyo subway attack: a 5-year follow-up study.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABA(A) receptor delta subunit

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Control of nerve agent-induced seizures is critical for neuroprotection and survival

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

The influence of subunit composition on the interaction of neurosteroids with GABA(A) receptors

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Continuous midazolam versus diazepam infusion for refractory convulsive status epilepticus

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid(A) receptor modulation and anesthesia

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Treatment of organophosphate poisoning. Experience of nerve agents and acute pesticide poisoning on the effects of oximes.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Chronic neurobehavioral and central and autonomic nervous system effects of Tokyo subway sarin poisoning

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

3 alpha-Hydroxy-3 beta-(phenylethynyl)-5 beta-pregnan-20-ones: synthesis and pharmacological activity of neuroactive steroids with high affinity for GABAA receptors

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063687

Organophosphates⧸Nerve Agent Poisoning: Mechanism of Action, Diagnosis, Prophylaxis, And Treatment

22 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111/NYAS.13160

Mechanism of seizures induced by di-isopropyl fluorophosphate

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27450921

12 December 2020

inferred from PubMed ID database lookup

Sarin poisoning in Tokyo subway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27450921

12 December 2020

inferred from PubMed ID database lookup

Treatment of status epilepticus in a large community hospital

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27450921

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1111/NYAS.13160

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27450921 AND SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27450921 AND SRC:MED&resulttype=core&format=json

19 March 2020

PubMed publication ID

27450921

1 reference