Voltage-gated sodium channel as a target for metastatic risk reduction with re-purposed drugs. (Q38894913)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27408684 AND SRC:MED&resulttype=core&format=json

18 March 2020

review article

1 reference

title

Voltage-gated sodium channel as a target for metastatic risk reduction with re-purposed drugs (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27408684 AND SRC:MED&resulttype=core&format=json

18 March 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27408684 AND SRC:MED&resulttype=core&format=json

18 March 2020

author name string

Tomas Koltai

series ordinal

1

1 reference

7 September 2017

22 July 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27408684 AND SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27408684 AND SRC:MED&resulttype=core&format=json

18 March 2020

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27408684 AND SRC:MED&resulttype=core&format=json

18 March 2020

page(s)

297

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27408684 AND SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

18 March 2020

copyright license

start time

22 July 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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14 September 2017

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14 September 2017

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Inhibition of cardiac voltage-gated sodium channels by grape polyphenols.

14 September 2017

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Inhibition of the rat brain sodium channel Nav1.2 after prolonged exposure to gabapentin

14 September 2017

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Human neoplastic mesothelial cells express voltage-gated sodium channels involved in cell motility

14 September 2017

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Small-cell lung cancer (human): potentiation of endocytic membrane activity by voltage-gated Na( ) channel expression in vitro

14 September 2017

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Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis.

14 September 2017

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Carbamazepine is an inhibitor of histone deacetylases

14 September 2017

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Voltage-gated Na channels confer invasive properties on human prostate cancer cells

14 September 2017

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Involvement of a novel fast inward sodium current in the invasion capacity of a breast cancer cell line

14 September 2017

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Contribution of functional voltage‐gated Na channel expression to cell behaviors involved in the metastatic cascade in rat prostate cancer: I. lateral motility

14 September 2017

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Sodium channel protein expression enhances the invasiveness of rat and human prostate cancer cells

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25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Inhibition of tumour spheroid-induced prometastatic intravasation gates in the lymph endothelial cell barrier by carbamazepine: drug testing in a 3D model

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Genistein inhibits voltage-gated sodium currents in SCG neurons through protein tyrosine kinase-dependent and kinase-independent mechanisms

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Flunarizine as a modulator of doxorubicin resistance in human colon-adenocarcinoma cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

In vitro and in vivo enhancement of vincristine antitumor activity on B16 melanoma cells by calcium antagonist flunarizine

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Cancer among epileptic patients exposed to anticonvulsant drugs

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

The effect of phenytoin on collagenase and gelatinase activities in UMR 106-01 rat osteoblastic osteosarcoma cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Nerve growth factor acts through cAMP-dependent protein kinase to increase the number of sodium channels in PC12 cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Segregation of the growth slowing effects of valproic acid from phenytoin and carbamazepine on lymphoid tumor cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

3HPhenytoin identifies a novel anticonvulsant-binding domain on voltage-dependent sodium channels

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Ion channels in spinal cord astrocytes in vitro. I. Transient expression of high levels of Na and K channels

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Depression of immune competence by phenytoin and carbamazepine. Studies in vivo and in vitro

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Nerve safety of tanezumab, a nerve growth factor inhibitor for pain treatment

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

The small GTPase RhoA regulates the expression and function of the sodium channel Nav1.5 in breast cancer cells.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Oxidative stress in the in vivo DMBA rat model of breast cancer: suppression by a voltage-gated sodium channel inhibitor (RS100642).

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Gabapentin selectively reduces persistent sodium current in injured type-A dorsal root ganglion neurons.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Anti-angiogenic action of 5,5-diphenyl-2-thiohydantoin-N10 (DPTH-N10).

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

The protein tyrosine kinase inhibitor, genistein, decreases excitability of nociceptive neurons

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

T-lymphocyte invasiveness: control by voltage-gated Na channel activity.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Anticonvulsant profile of flunarizine and relation to Na( ) channel blocking effects

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Voltage-gated sodium ion channels in prostate cancer: expression and activity

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Intravenous anesthetic, propofol inhibits invasion of cancer cells

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Infiltration anesthetic lidocaine inhibits cancer cell invasion by modulating ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF).

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Inhibition by anticonvulsants of prostate-specific antigen and interleukin-6 secretion by human prostate cancer cells

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Additivity of dilantin and vinblastine inhibitory effects on microtubule assembly

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

R56865 and flunarizine as Na( )-channel blockers in isolated Purkinje neurons of rat cerebellum

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

Astrocyte Na channels are required for maintenance of Na /K( )-ATPase activity.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920216

[Inhibitory effect of carbamazepine on proliferation of estrogen-dependent breast cancer cells]

22 August 2018

1 reference

12 December 2020

Effect of chronic anticonvulsant monotherapy on lymphocyte subpopulations in adult epileptic patients

1 reference

12 December 2020

Inhibitory effect of calcium channel blockers on growth of pancreatic cancer cells

1 reference

12 December 2020

Effects of a calcium-antagonist (flunarizine) on cancer cell movement and phagocytosis

1 reference

12 December 2020

Inhibition of melanoma cell directional migration in vitro via different cellular targets

1 reference

12 December 2020

Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells

1 reference

12 December 2020

Flunarizine blocks voltage-gated Na( ) and Ca(2 ) currents in cultured rat cortical neurons: A possible locus of action in the prevention of migraine

1 reference

12 December 2020

Effects of phenytoin on cell-mediated immunity

1 reference

12 December 2020

Modulation of melphalan and cisplatin cytotoxicity in human ovarian cancer cells resistant to alkylating drugs

1 reference

12 December 2020

Functional expression of voltage-gated sodium channels in primary cultures of human cervical cancer

1 reference

12 December 2020

Characterization of the block of sodium channels by phenytoin in mouse neuroblastoma cells

1 reference

12 December 2020

Transient antibody deficiency and abnormal t-suppressor cells induced by phenytoin

1 reference

12 December 2020

Effects of a calcium-antagonist (flunarizine) on the in vitro growth of B16 mouse melanoma cells

1 reference

12 December 2020

Correlation of melanoma cell motility and invasion in vitro

1 reference

12 December 2020

Search for anti-metastatic therapy: Effects of phenytoin on B16 melanoma metastasis

1 reference

12 December 2020

Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells

1 reference

12 December 2020

Phenytoin-induced lymphadenopathy

1 reference

12 December 2020

Phenytoin is an estrogen receptor α-selective modulator that interacts with helix 12

1 reference

12 December 2020

Blood flow, vascular resistance and oxygen availability in malignant tumours upon intravenous flunarizine

1 reference

12 December 2020

The reversible P2Y12 inhibitor ticagrelor inhibits metastasis and improves survival in mouse models of cancer

1 reference

12 December 2020

10.12688/F1000RESEARCH.6789.1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27408684 AND SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27408684 AND SRC:MED&resulttype=core&format=json

18 March 2020

PubMed publication ID

27408684

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27408684 AND SRC:MED&resulttype=core&format=json