Antigen-specific impairment of adoptive T-cell therapy against cancer: players, mechanisms, solutions and a hypothesis (Q38869740)

7 September 2017

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title

Antigen-specific impairment of adoptive T-cell therapy against cancer: players, mechanisms, solutions and a hypothesis (English)

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7 September 2017

1

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7 September 2017

publication date

1 July 2016

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7 September 2017

published in

Immunological Reviews

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7 September 2017

volume

272

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7 September 2017

issue

1

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7 September 2017

page(s)

169-182

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Adoptive immunotherapy for cancer: harnessing the T cell response

7 September 2017

cites work

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Gene-engineered T cells for cancer therapy

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Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors.

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Adoptive immunotherapy for cancer or viruses

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Is cancer gene therapy an empty suit?

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T-cell immunotherapy: looking forward

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Targeting natural killer cells and natural killer T cells in cancer

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Adoptive T Cell Therapy Targeting CD1 and MR1

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CD8( ) T cells: foot soldiers of the immune system

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The role of the proteasome in the generation of MHC class I ligands and immune responses

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Pathways of antigen processing

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Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion

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Neoantigens in cancer immunotherapy.

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Insights into the processing of MHC class I ligands gained from the study of human tumor epitopes

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Quantifying epitope presentation using mass spectrometry

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Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.

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Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy

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Mechanisms of action of therapeutic antibodies for cancer

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Adoptive cell transfer as personalized immunotherapy for human cancer

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The use of endogenous T cells for adoptive transfer

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Prospects for gene-engineered T cell immunotherapy for solid cancers.

21 January 2018

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Re-adapting T cells for cancer therapy: from mouse models to clinical trials

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The basic principles of chimeric antigen receptor design

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Design and development of therapies using chimeric antigen receptor-expressing T cells

21 January 2018

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Engineering T cells for cancer: our synthetic future

21 January 2018

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Induction of antigen-specific effector-phase tolerance following vaccination against a previously ignored B-cell lymphoma

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Target Density, Not Affinity or Avidity of Antigen Recognition, Determines Adoptive T Cell Therapy Outcomes in a Mouse Lymphoma Model.

21 January 2018

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Impaired T-Cell Function in B-Cell Lymphoma: A Direct Consequence of Events at the Immunological Synapse?

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T cell receptor antagonist peptides induce positive selection

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Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance

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Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold.

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Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection.

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Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

21 January 2018

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Functional differences between low- and high-affinity CD8( ) T cells in the tumor environment

21 January 2018

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Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity

21 January 2018

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T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

21 January 2018

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Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

21 January 2018

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Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen

21 January 2018

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High Avidity Cytotoxic T Lymphocytes Can Be Selected into the Memory Pool but They Are Exquisitely Sensitive to Functional Impairment

21 January 2018

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Characterization of two TCR transgenic mouse lines specific for herpes simplex virus.

21 January 2018

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Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens

21 January 2018

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The dominant role of CD8 dendritic cells in cross-presentation is not dictated by antigen capture

21 January 2018

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Batf3 Deficiency Reveals a Critical Role for CD8 Dendritic Cells in Cytotoxic T Cell Immunity

21 January 2018

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Cross-presentation, dendritic cells, tolerance and immunity

21 January 2018

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Myeloid-derived suppressor cell impact on endogenous and adoptively transferred T cells

21 January 2018

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The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

21 January 2018

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Tumor-associated CD8 T cell tolerance induced by bone marrow-derived immature myeloid cells

21 January 2018

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Antigen-specific inhibition of CD8 T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species.

21 January 2018

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B cells directly tolerize CD8( ) T cells

21 January 2018

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Positive and negative selection of T cells

21 January 2018

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Peripheral tolerance of CD8 T lymphocytes

21 January 2018

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How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

21 January 2018

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T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity

21 January 2018

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From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

21 January 2018

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Naturally arising Foxp3-expressing CD25 CD4 regulatory T cells in immunological tolerance to self and non-self

21 January 2018

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21 January 2018

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In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity

21 January 2018

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Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice

21 January 2018

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Targeting antigen to diverse APCs inactivates memory CD8 T cells without eliciting tissue-destructive effector function

21 January 2018

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Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses

21 January 2018

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Immune outcomes in the liver: Is CD8 T cell fate determined by the environment?

21 January 2018

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Harnessing the immune response to treat cancer

21 January 2018

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The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12433

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7 September 2017

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