Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs (Q38844409)

6 September 2017

title

Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs (English)

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6 September 2017

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9

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6 September 2017

Feng-Lan Chiu

1

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6 September 2017

Jun-Tasi Lin

2

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Ching-Yu Chuang

3

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6 September 2017

Ting Chien

4

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6 September 2017

Chiung-Mei Chen

5

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Kai-Hsiang Chen

6

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Han-Yun Hsiao

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Yow-Sien Lin

8

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Hung-Chih Kuo

10

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publication date

11 August 2015

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6 September 2017

published in

Human Molecular Genetics

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volume

24

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6 September 2017

issue

21

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6 September 2017

page(s)

6066-6079

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Medium spiny neurons for transplantation in Huntington's disease

6 September 2017

cites work

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Differential loss of striatal projection neurons in Huntington disease

21 January 2018

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Choosing an animal model for the study of Huntington's disease

21 January 2018

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Medicine. iPSC disease modeling

21 January 2018

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Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats.

21 January 2018

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Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes

21 January 2018

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Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells

21 January 2018

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Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function.

21 January 2018

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Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease

21 January 2018

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In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons

21 January 2018

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Glutamate-induced alterations in Ca2 signaling are modulated by mitochondrial Ca2 handling capacity in brain slices of R6/1 transgenic mice.

21 January 2018

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Generalized brain and skin proteasome inhibition in Huntington's disease

21 January 2018

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Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

21 January 2018

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Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse

21 January 2018

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cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues

21 January 2018

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CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model.

21 January 2018

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Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease

21 January 2018

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A critical evaluation of adenosine A2A receptors as potentially "druggable" targets in Huntington's disease.

21 January 2018

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Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

21 January 2018

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FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity

21 January 2018

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Glial cell line-derived neurotrophic factor (GDNF) enhances dopamine release from striatal nerve endings in an adenosine A2A receptor-dependent manner.

21 January 2018

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Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease

21 January 2018

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Influence of CGS 21680, a selective adenosine A(2A) receptor agonist, on NMDA receptor function and expression in the brain of Huntington's disease mice.

21 January 2018

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Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells

21 January 2018

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The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity

21 January 2018

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Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

21 January 2018

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DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

21 January 2018

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Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease

21 January 2018

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Reversal of cellular phenotypes in neural cells derived from Huntington's disease monkey-induced pluripotent stem cells

21 January 2018

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DNA damage induced by polyglutamine-expanded proteins

21 January 2018

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Important role of oxidative stress biomarkers in Huntington's disease.

21 January 2018

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Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.

21 January 2018

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Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

21 January 2018

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Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model

21 January 2018

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When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?

21 January 2018

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Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal

21 January 2018

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The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system

21 January 2018

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A new drug design targeting the adenosinergic system for Huntington's disease

21 January 2018

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BDNF prevents NMDA-induced toxicity in models of Huntington's disease: the effects are genotype specific and adenosine A2A receptor is involved.

21 January 2018

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A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease

21 January 2018

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Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's disease

21 January 2018

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Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington's disease transgenic mice prior to the onset of motor symptoms

21 January 2018

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Adenosine modulates hypoxia‐induced responses in rat PC12 cells via the A2A receptor

21 January 2018

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Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells

21 January 2018

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Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32 medium-sized spiny neurons

21 January 2018

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Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

21 January 2018

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In vitro expansion of a multipotent population of human neural progenitor cells

21 January 2018

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GABAergic immunoreactivity is predominant in neurons derived from expanded human neural precursor cells in vitro.

21 January 2018

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Activation of adenosine A1 receptors underlies anticonvulsant effect of CGS21680.

21 January 2018

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Identification of the A2 adenosine receptor binding subunit by photoaffinity crosslinking

21 January 2018

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Factors from human embryonic stem cell-derived fibroblast-like cells promote topology-dependent hepatic differentiation in primate embryonic and induced pluripotent stem cells

21 January 2018

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

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Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/HMG/DDV318

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6 September 2017

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