Progranulin: A key player in autoimmune diseases. (Q38831044)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27527809 AND SRC:MED&resulttype=core&format=json

21 March 2020

review article

1 reference

title

Progranulin: A key player in autoimmune diseases (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27527809 AND SRC:MED&resulttype=core&format=json

21 March 2020

4

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21 March 2020

author name string

Jinlong Jian

series ordinal

1

1 reference

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21 March 2020

Guangfei Li

series ordinal

2

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21 March 2020

Aubryanna Hettinghouse

series ordinal

3

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21 March 2020

publication date

12 August 2016

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21 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27527809 AND SRC:MED&resulttype=core&format=json

21 March 2020

volume

101

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21 March 2020

page(s)

48-55

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Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner

21 March 2020

cites work

1 reference

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The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1.

15 September 2018

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Mechanisms behind efficacy of tumor necrosis factor inhibitors in inflammatory bowel diseases

15 September 2018

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Does progranulin account for the opposite effects of etanercept and infliximab/adalimumab in osteoarthritis?: Comment on Olson et al.: "Therapeutic Opportunities to Prevent Post-Traumatic Arthritis: Lessons From the Natural History of Arthritis Afte

15 September 2018

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Progranulin induces adipose insulin resistance and autophagic imbalance via TNFR1 in mice

15 September 2018

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Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis

15 September 2018

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The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator

15 September 2018

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Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes.

15 September 2018

1 reference

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Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner

15 September 2018

1 reference

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The molecular basis for development of proinflammatory autoantibodies to progranulin

15 September 2018

1 reference

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Therapeutic opportunities to prevent post-traumatic arthritis: Lessons from the natural history of arthritis after articular fracture

15 September 2018

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The TL1A/DR3/DcR3 pathway in autoimmune rheumatic diseases

15 September 2018

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Intra-articular transplantation of atsttrin-transduced mesenchymal stem cells ameliorate osteoarthritis development

15 September 2018

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PGRN induces impaired insulin sensitivity and defective autophagy in hepatic insulin resistance

15 September 2018

1 reference

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Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis

15 September 2018

1 reference

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Progranulin is preferentially expressed in patients with psoriasis vulgaris and protects mice from psoriasis-like skin inflammation.

15 September 2018

1 reference

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Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis

15 September 2018

1 reference

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Progranulin facilitates conversion and function of regulatory T cells under inflammatory conditions.

15 September 2018

1 reference

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PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner

15 September 2018

1 reference

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Upregulated expression level of the growth factor, progranulin, is associated with the development of primary Sjögren's syndrome

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303690

Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling

15 September 2018

1 reference

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TNF receptors: signaling pathways and contribution to renal dysfunction

15 September 2018

1 reference

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Etanercept: a review of its use in autoimmune inflammatory diseases

15 September 2018

1 reference

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Circulating PGRN is significantly associated with systemic insulin sensitivity and autophagic activity in metabolic syndrome

15 September 2018

1 reference

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Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation

15 September 2018

1 reference

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TNF/TNFR: drug target for autoimmune diseases and immune-mediated inflammatory diseases

15 September 2018

1 reference

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Progranulin protein levels are differently regulated in plasma and CSF.

15 September 2018

1 reference

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Progranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity

15 September 2018

1 reference

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Establishment of a surgically-induced model in mice to investigate the protective role of progranulin in osteoarthritis

15 September 2018

1 reference

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Proinflammatory progranulin antibodies in inflammatory bowel diseases

15 September 2018

1 reference

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The role of TL1A and DR3 in autoimmune and inflammatory diseases

15 September 2018

1 reference

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Progranulin antibodies entertain a proinflammatory environment in a subgroup of patients with psoriatic arthritis

15 September 2018

1 reference

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Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains

15 September 2018

1 reference

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Granulin exacerbates lupus nephritis via enhancing macrophage M2b polarization

15 September 2018

1 reference

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The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling

15 September 2018

1 reference

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Comment on: Richter et al. Serum levels of the adipokine progranulin depend on renal function. Diabetes Care 2013;36:410-414.

15 September 2018

1 reference

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Expression level of the growth factor progranulin is related with development of systemic lupus erythematosus

15 September 2018

1 reference

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Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice.

15 September 2018

1 reference

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Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance

15 September 2018

1 reference

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Progranulin antibodies in autoimmune diseases

15 September 2018

1 reference

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Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303690

Serum levels of the adipokine progranulin depend on renal function

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303690

GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients

15 September 2018

1 reference

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Obesity, inflammation and resting energy expenditure: possible mechanism of progranulin in this pathway.

15 September 2018

1 reference

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PKC signaling is involved in the regulation of progranulin (acrogranin/PC-cell-derived growth factor/granulin-epithelin precursor) protein expression in human ovarian cancer cell lines

15 September 2018

1 reference

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Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).

15 September 2018

1 reference

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Sjögren's syndrome, the old and the new.

15 September 2018

1 reference

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PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue

15 September 2018

1 reference

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Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism

15 September 2018

1 reference

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The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice

15 September 2018

1 reference

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Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein

15 September 2018

1 reference

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Overview of pathogenesis of systemic sclerosis

15 September 2018

1 reference

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Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303690

Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach

15 September 2018

1 reference

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Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303690

Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding

15 September 2018

1 reference

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Mutations in progranulin gene: clinical, pathological, and ribonucleic acid expression findings.

15 September 2018

1 reference

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303690

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

15 September 2018

1 reference

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Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study

15 September 2018

1 reference

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Signalling pathways of the TNF superfamily: a double-edged sword

15 September 2018

1 reference

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Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis

15 September 2018

1 reference

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The TNF-alpha transgenic mouse model of inflammatory arthritis

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303690

Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

15 September 2018

1 reference

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Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease

15 September 2018

1 reference

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Progranulin is a mediator of the wound response

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303690

Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays

15 September 2018

1 reference

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Biological activities and signaling pathways of the granulin/epithelin precursor

15 September 2018

1 reference

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The hairpin stack fold, a novel protein architecture for a new family of protein growth factors

15 September 2018

1 reference

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Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts.

15 September 2018

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Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins

15 September 2018

1 reference

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Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional

15 September 2018

1 reference

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Acrosome biogenesis begins during meiosis: evidence from the synthesis and distribution of an acrosomal glycoprotein, acrogranin, during guinea pig spermatogenesis

15 September 2018

1 reference

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The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth

15 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303690

Progranulin Overproduction Due to Fli-1 Deficiency Contributes to the Resistance of Dermal Fibroblasts to Tumor Necrosis Factor in Systemic Sclerosis

15 September 2018

1 reference

12 December 2020

Progranulin genetic polymorphisms influence progression of disability and relapse recovery in multiple sclerosis

1 reference

12 December 2020

Increased serum GP88 (Progranulin) concentrations in rheumatoid arthritis

1 reference

12 December 2020

Clinical significance of serum decoy receptor 3 levels in patients with systemic sclerosis

1 reference

12 December 2020

Circulating progranulin levels in women with gestational diabetes mellitus and healthy controls during and after pregnancy

1 reference

12 December 2020

Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males

1 reference

12 December 2020

Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis

1 reference

12 December 2020

Serum progranulin irrelated with Breg cell levels, but elevated in RA patients, reflecting high disease activity

1 reference

12 December 2020

Antagonistic Effects of TNF-α on TGF-β Signaling Through Down-Regulation of TGF-β Receptor Type II in Human Dermal Fibroblasts

1 reference

12 December 2020

10.1016/J.CYTO.2016.08.007

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27527809 AND SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27527809 AND SRC:MED&resulttype=core&format=json

21 March 2020

PubMed publication ID

27527809

1 reference