Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response. (Q38822665)

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28 February 2020

title

Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response (English)

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2

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author name string

Ryota Saito

1

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28 February 2020

Keiichiro Hiramoto

3

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28 February 2020

Soichiro Asami

4

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28 February 2020

Eriko Naganuma

5

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28 February 2020

Hiromi Suda

6

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28 February 2020

Tatsuro Iso

7

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28 February 2020

Hirotaka Yamamoto

8

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28 February 2020

Masanobu Morita

9

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28 February 2020

Liam Baird

10

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28 February 2020

Yuki Furusawa

11

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28 February 2020

Takaaki Negishi

12

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28 February 2020

Masakazu Ichinose

13

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28 February 2020

Masayuki Yamamoto

14

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28 February 2020

language of work or name

English

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publication date

2 November 2015

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Molecular and Cellular Biology

28 February 2020

published in

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28 February 2020

volume

36

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28 February 2020

issue

2

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28 February 2020

page(s)

271-284

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Molecular basis of the Keap1-Nrf2 system.

28 February 2020

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1 reference

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Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO

9 September 2017

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Nrf2 enhances cholangiocyte expansion in Pten-deficient livers

9 September 2017

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Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

9 September 2017

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The Keap1-Nrf2 system prevents onset of diabetes mellitus

9 September 2017

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Update on the Kelch-like (KLHL) gene family

9 September 2017

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Toward clinical application of the Keap1-Nrf2 pathway

9 September 2017

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9 September 2017

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Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels.

9 September 2017

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Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

9 September 2017

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Mechanism of chemical activation of Nrf2

9 September 2017

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Modification of keap1 cysteine residues by sulforaphane

9 September 2017

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Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism

9 September 2017

1 reference

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Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish

9 September 2017

1 reference

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Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

9 September 2017

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The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response

9 September 2017

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Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

9 September 2017

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Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.

9 September 2017

1 reference

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The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

9 September 2017

1 reference

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9 September 2017

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Direct and indirect antioxidant properties of inducers of cytoprotective proteins

9 September 2017

1 reference

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Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

9 September 2017

1 reference

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Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

9 September 2017

1 reference

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Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

9 September 2017

1 reference

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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

9 September 2017

1 reference

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Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

9 September 2017

1 reference

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

9 September 2017

1 reference

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Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

9 September 2017

1 reference

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

9 September 2017

1 reference

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

9 September 2017

1 reference

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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

9 September 2017

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

9 September 2017

1 reference

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

9 September 2017

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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

9 September 2017

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The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4719294

Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo.

9 September 2017

1 reference

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Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4719294

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4719294

Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4719294

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

14 September 2017

1 reference

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Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4719294

Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4719294

Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4719294

Subcellular localization and cytoplasmic complex status of endogenous Keap1.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4719294

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

22 August 2018

1 reference

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Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers

22 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26527616

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.00868-15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26527616 AND SRC:MED&resulttype=core&format=json

28 February 2020

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28 February 2020

PubMed publication ID

26527616

1 reference