Unveiling the diversity of cyclotides by combining peptidome and transcriptome analysis (Q38815517)

6 September 2017

title

Unveiling the diversity of cyclotides by combining peptidome and transcriptome analysis (English)

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6 September 2017

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6 September 2017

Johannes Koehbach

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6 September 2017

publication date

22 April 2016

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6 September 2017

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6 September 2017

volume

106

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6 September 2017

issue

6

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6 September 2017

page(s)

774-783

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Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

6 September 2017

cites work

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Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors

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Antimicrobial peptides in animals and their role in host defences

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The future of peptide-based drugs

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Naturally occurring circular proteins: distribution, biosynthesis and evolution.

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Endless peptides--circular forms in nature

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Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

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Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif

21 January 2018

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Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design.

21 January 2018

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CyBase: a database of cyclic protein sequence and structure

21 January 2018

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Analysis and classification of circular proteins in CyBase

21 January 2018

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Identification and structural characterization of novel cyclotide with activity against an insect pest of sugar cane

21 January 2018

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Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa

21 January 2018

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Do plant cyclotides have potential as immunosuppressant peptides?

21 January 2018

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Discovery of defense- and neuropeptides in social ants by genome-mining

21 January 2018

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Cyclotide discovery in Gentianales revisited--identification and characterization of cyclic cystine-knot peptides and their phylogenetic distribution in Rubiaceae plants

21 January 2018

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Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity

21 January 2018

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Genome mining for ribosomally synthesized natural products

21 January 2018

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Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1

21 January 2018

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Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes

21 January 2018

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Expression of Viola cyclotides by liquid chromatography-mass spectrometry and tandem mass spectrometry sequencing of intercysteine loops after introduction of charges and cleavage sites by aminoethylation

21 January 2018

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Elucidating the structure of cyclotides by partial acid hydrolysis and LC-MS/MS analysis.

21 January 2018

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A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability.

21 January 2018

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First cyclotide from Hybanthus (Violaceae).

21 January 2018

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Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa

21 January 2018

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Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.

21 January 2018

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Characterizing circular peptides in mixtures: sequence fragment assembly of cyclotides from a violet plant by MALDI-TOF/TOF mass spectrometry

21 January 2018

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Discovery of an unusual biosynthetic origin for circular proteins in legumes

21 January 2018

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Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family

21 January 2018

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Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins.

21 January 2018

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Cyclotides associate with leaf vasculature and are the products of a novel precursor in petunia (Solanaceae)

21 January 2018

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Isolation and characterization of cytotoxic cyclotides from Viola philippica.

21 January 2018

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Peptide quantification by matrix-assisted laser desorption ionisation time-of-flight mass spectrometry: investigations of the cyclotide kalata B1 in biological fluids.

21 January 2018

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Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry

21 January 2018

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Variations in cyclotide expression in viola species

21 January 2018

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Plant thionins--the structural perspective

21 January 2018

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Squash inhibitors: from structural motifs to macrocyclic knottins

21 January 2018

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Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities

21 January 2018

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A new "era" for cyclotide sequencing.

21 January 2018

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Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining

21 January 2018

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Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae.

21 January 2018

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A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae)

21 January 2018

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Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinis

21 January 2018

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Cyclotide proteins and precursors from the genus Gloeospermum: filling a blank spot in the cyclotide map of Violaceae

21 January 2018

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Identification of two suites of cyclotide precursor genes from metallophyte Viola baoshanensis: cDNA sequence variation, alternative RNA splicing and potential cyclotide diversity

21 January 2018

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The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity

21 January 2018

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Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants

21 January 2018

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Bioinformatics challenges in de novo transcriptome assembly using short read sequences in the absence of a reference genome sequence.

21 January 2018

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Reference-free transcriptome assembly in non-model animals from next-generation sequencing data.

21 January 2018

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Discovery of cyclotide-like protein sequences in graminaceous crop plants: ancestral precursors of circular proteins?

21 January 2018

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Basic local alignment search tool

21 January 2018

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Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis

21 January 2018

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Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

21 January 2018

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Insights into processing and cyclization events associated with biosynthesis of the cyclic Peptide kalata B1.

21 January 2018

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Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis

21 January 2018

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Transcriptomic screening for cyclotides and other cysteine-rich proteins in the metallophyte Viola baoshanensis.

21 January 2018

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Two Blast-independent tools, CyPerl and CyExcel, for harvesting hundreds of novel cyclotides and analogues from plant genomes and protein databases

21 January 2018

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High-performance computational analysis and peptide screening from databases of cyclotides from poaceae.

21 January 2018

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Prediction and characterization of cyclic proteins from sequences in three domains of life

21 January 2018

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Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases

21 January 2018

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Automated genome mining of ribosomal peptide natural products

21 January 2018

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Exogenous plant hormones and cyclotide expression in Viola uliginosa (Violaceae).

21 January 2018

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Formation of cyclotides and variations in cyclotide expression in Oldenlandia affinis suspension cultures

21 January 2018

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Tissue-specific expression of head-to-tail cyclized miniproteins in Violaceae and structure determination of the root cyclotide Viola hederacea root cyclotide1.

21 January 2018

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Cyclotides as grafting frameworks for protein engineering and drug design applications.

21 January 2018

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Cyclotide structure-activity relationships: qualitative and quantitative approaches linking cytotoxic and anthelmintic activity to the clustering of physicochemical forces

21 January 2018

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Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature?

21 January 2018

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Insecticidal plant cyclotides and related cystine knot toxins

21 January 2018

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Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions

21 January 2018

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Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions

21 January 2018

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Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

21 January 2018

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Distribution and evolution of circular miniproteins in flowering plants

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIP.22858

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6 September 2017

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