In silico polypharmacology of natural products (Q38810969)

6 September 2017

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title

In silico polypharmacology of natural products (English)

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6 September 2017

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Feixiong Cheng

5

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author name string

Jiansong Fang

1

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6 September 2017

Chuang Liu

2

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6 September 2017

Qi Wang

3

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6 September 2017

Ping Lin

4

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6 September 2017

publication date

27 April 2017

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Briefings in Bioinformatics

6 September 2017

published in

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The re-emergence of natural products for drug discovery in the genomics era.

6 September 2017

cites work

1 reference

Natural product and natural product derived drugs in clinical trials.

21 January 2018

1 reference

A New Golden Age of Natural Products Drug Discovery

21 January 2018

1 reference

Molecular targets of phytochemicals for cancer prevention

21 January 2018

1 reference

Drug-target interaction prediction via chemogenomic space: learning-based methods

21 January 2018

1 reference

The efficiency of multi-target drugs: the network approach might help drug design

21 January 2018

1 reference

Polypharmacology: challenges and opportunities in drug discovery

21 January 2018

1 reference

21 January 2018

Cancer genome landscapes

1 reference

The next steps in next-gen sequencing of cancer genomes

21 January 2018

1 reference

Systems pharmacology for drug discovery and development: paradigm shift or flash in the pan?

21 January 2018

1 reference

Effect of Liuwei Dihuang decoction, a traditional Chinese medicinal prescription, on the neuroendocrine immunomodulation network.

21 January 2018

1 reference

Systems Pharmacology-Based Discovery of Natural Products for Precision Oncology Through Targeting Cancer Mutated Genes.

21 January 2018

1 reference

Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential

21 January 2018

1 reference

21 January 2018

Cancer Statistics, 2017.

1 reference

Natural products: a continuing source of novel drug leads

21 January 2018

1 reference

Oncogenomics and the development of new cancer therapies

21 January 2018

1 reference

Rapid learning for precision oncology

21 January 2018

1 reference

Cancer prevention and therapy through the modulation of the tumor microenvironment

21 January 2018

1 reference

Immunosuppressive cells in tumor immune escape and metastasis

21 January 2018

1 reference

Molecular targets of curcumin for cancer therapy: an updated review.

21 January 2018

1 reference

Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications

21 January 2018

1 reference

Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma Model.

21 January 2018

1 reference

Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications

21 January 2018

1 reference

Indoleamine 2,3-dioxygenase, an immunomodulatory protein, is suppressed by (-)-epigallocatechin-3-gallate via blocking of gamma-interferon-induced JAK-PKC-delta-STAT1 signaling in human oral cancer cells

21 January 2018

1 reference

(-)-Epigallocatechin gallate regulates CD3-mediated T cell receptor signaling in leukemia through the inhibition of ZAP-70 kinase

21 January 2018

1 reference

Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update

21 January 2018

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Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways

21 January 2018

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Molecular mechanisms of action of quercetin in cancer: recent advances

21 January 2018

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Quercetin and interferon-beta modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients

21 January 2018

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The immunostimulating activity of quercetin 3-O-xyloside in murine macrophages via activation of the ASK1/MAPK/NF-κB signaling pathway

21 January 2018

1 reference

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

21 January 2018

1 reference

Interferon gamma induced by resveratrol analog, HS-1793, reverses the properties of tumor associated macrophages

21 January 2018

1 reference

Pharmacological effects of berberine and its derivatives: a patent update

21 January 2018

1 reference

Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer

21 January 2018

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Berberine and Coptidis Rhizoma as potential anticancer agents: Recent updates and future perspectives

21 January 2018

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Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells

21 January 2018

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Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition

21 January 2018

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Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9.

21 January 2018

1 reference

Inflammation, macrophage in cancer progression and chinese herbal treatment.

21 January 2018

1 reference

The Essential Medicinal Chemistry of Curcumin

21 January 2018

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Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.

21 January 2018

1 reference

Chemo- and bioinformatics resources for in silico drug discovery from medicinal plants beyond their traditional use: a critical review

21 January 2018

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Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

21 January 2018

1 reference

21 January 2018

1 reference

The ChEMBL bioactivity database: an update

21 January 2018

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BindingDB in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacology

21 January 2018

1 reference

An overview of the PubChem BioAssay resource

21 January 2018

1 reference

DrugBank 4.0: shedding new light on drug metabolism

21 January 2018

1 reference

Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information

21 January 2018

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DGIdb 2.0: mining clinically relevant drug-gene interactions.

21 January 2018

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STITCH 4: integration of protein-chemical interactions with user data

21 January 2018

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SuperPred: update on drug classification and target prediction

21 January 2018

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HIT: linking herbal active ingredients to targets

21 January 2018

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TCMID: Traditional Chinese Medicine integrative database for herb molecular mechanism analysis

21 January 2018

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TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

21 January 2018

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NPACT: Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target database

21 January 2018

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CancerHSP: anticancer herbs database of systems pharmacology.

21 January 2018

1 reference

InnateDB: systems biology of innate immunity and beyond--recent updates and continuing curation

21 January 2018

1 reference

Immunome: a reference set of genes and proteins for systems biology of the human immune system.

21 January 2018

1 reference

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data.

21 January 2018

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The Innate Immune Database (IIDB)

21 January 2018

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The Immunological Genome Project: networks of gene expression in immune cells.

21 January 2018

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The Connectivity Map: a new tool for biomedical research

21 January 2018

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LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures

21 January 2018

1 reference

Open TG-GATEs: a large-scale toxicogenomics database

21 January 2018

1 reference

Toxicogenomics in drug discovery and development: mechanistic analysis of compound/class-dependent effects using the DrugMatrix database

21 January 2018

1 reference

The BioGRID interaction database: 2015 update

21 January 2018

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Human Protein Reference Database--2009 update

21 January 2018

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The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible

21 January 2018

1 reference

MINT, the molecular interaction database: 2012 update

21 January 2018

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International network of cancer genome projects

21 January 2018

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COSMIC: exploring the world's knowledge of somatic mutations in human cancer

21 January 2018

1 reference

Chemogenomics: an emerging strategy for rapid target and drug discovery

21 January 2018

1 reference

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

21 January 2018

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Genetics: Big hopes for big data

21 January 2018

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Quantitative network mapping of the human kinome interactome reveals new clues for rational kinase inhibitor discovery and individualized cancer therapy

21 January 2018

1 reference

A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types

21 January 2018

1 reference

Biomarker-based drug safety assessment in the age of systems pharmacology: from foundational to regulatory science

21 January 2018

1 reference

Systems Biology-Based Investigation of Cellular Antiviral Drug Targets Identified by Gene-Trap Insertional Mutagenesis

21 January 2018

1 reference

Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CA H1047R in HER2/ER-positive breast cancer

21 January 2018

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Studying tumorigenesis through network evolution and somatic mutational perturbations in the cancer interactome

21 January 2018

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Advances in computational approaches for prioritizing driver mutations and significantly mutated genes in cancer genomes

21 January 2018

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Cancer whole-genome sequencing: present and future.

21 January 2018

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Drug-target interaction prediction: databases, web servers and computational models

21 January 2018

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From in silico target prediction to multi-target drug design: current databases, methods and applications

21 January 2018

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Approaches to target profiling of natural products.

21 January 2018

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Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening

21 January 2018

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Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting epidermal growth factor receptor

21 January 2018

1 reference

Inverse virtual screening of antitumor targets: pilot study on a small database of natural bioactive compounds.

21 January 2018

1 reference

Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers

21 January 2018

1 reference

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks

21 January 2018

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Prediction of drug-target interaction networks from the integration of chemical and genomic spaces.

21 January 2018

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Supervised prediction of drug-target interactions using bipartite local models

21 January 2018

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A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data

21 January 2018

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Prediction of drug-target interactions and drug repositioning via network-based inference

21 January 2018

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Prediction of chemical-protein interactions network with weighted network-based inference method

21 January 2018

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In silico prediction of chemical mechanism of action via an improved network-based inference method

21 January 2018

1 reference

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

21 January 2018

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Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance

21 January 2018

1 reference

Tracking cancer drugs in living cells by thermal profiling of the proteome

21 January 2018

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Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

21 January 2018

1 reference

Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State.

21 January 2018

1 reference

Exometabolome analysis identifies pyruvate dehydrogenase as a target for the antibiotic triphenylbismuthdichloride in multiresistant bacterial pathogens.

21 January 2018

1 reference

A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling

21 January 2018

1 reference

Biochemical disorders induced by cytotoxic marine natural products in breast cancer cells as revealed by proton NMR spectroscopy-based metabolomics

21 January 2018

1 reference

Established and emerging trends in computational drug discovery in the structural genomics era

21 January 2018

1 reference

Molecular Docking for Identification of Potential Targets for Drug Repurposing.

21 January 2018

1 reference

Drug Repositioning Through Network Pharmacology

21 January 2018

1 reference

Structures of androgen receptor bound with ligands: advancing understanding of biological functions and drug discovery

21 January 2018

1 reference

Challenges and opportunities in targeting the menin-MLL interaction

21 January 2018

1 reference

Ligand-protein inverse docking and its potential use in the computer search of protein targets of a small molecule

21 January 2018

1 reference

idTarget: a web server for identifying protein targets of small chemical molecules with robust scoring functions and a divide-and-conquer docking approach

21 January 2018

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Inverse Virtual Screening allows the discovery of the biological activity of natural compounds.

21 January 2018

1 reference

Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach

21 January 2018

1 reference

Systematic Prioritization of Druggable Mutations in ∼5000 Genomes Across 16 Cancer Types Using a Structural Genomics-based Approach

21 January 2018

1 reference

FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach

21 January 2018

1 reference

Machine-learning approaches in drug discovery: methods and applications

21 January 2018

1 reference

Chemical Structure Similarity Search for Ligand-based Virtual Screening: Methods and Computational Resources.

21 January 2018

1 reference

PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach

21 January 2018

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Enhancing molecular shape comparison by weighted Gaussian functions

21 January 2018

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Predictions of BuChE inhibitors using support vector machine and naive Bayesian classification techniques in drug discovery

21 January 2018

1 reference

Consensus models for CDK5 inhibitors in silico and their application to inhibitor discovery.

21 January 2018

1 reference

Discovery of multitarget-directed ligands against Alzheimer's disease through systematic prediction of chemical-protein interactions

21 January 2018

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In silico ADMET prediction: recent advances, current challenges and future trends

21 January 2018

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Improving compound-protein interaction prediction by building up highly credible negative samples

21 January 2018

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Chemogenomic approaches to infer drug-target interaction networks

21 January 2018

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Network-Based Relating Pharmacological and Genomic Spaces for Drug Target Identification

21 January 2018

1 reference

Systems pharmacology in drug discovery and therapeutic insight for herbal medicines

21 January 2018

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Prediction of chemical-protein interactions: multitarget-QSAR versus computational chemogenomic methods.

21 January 2018

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Prediction of human genes and diseases targeted by xenobiotics using predictive toxicogenomic-derived models (PTDMs).

21 January 2018

1 reference

Systems biology: a brief overview

21 January 2018

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Computational systems biology

21 January 2018

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Systems biology in drug discovery and development

21 January 2018

1 reference

Drug Repurposing: New Treatments for Zika Virus Infection?

21 January 2018

1 reference

Applications of Connectivity Map in drug discovery and development

21 January 2018

1 reference

Proteomics: from single molecules to biological pathways

21 January 2018

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Mass spectrometry-based proteomics and network biology

21 January 2018

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Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry.

21 January 2018

1 reference

Metabolomics: a global biochemical approach to drug response and disease

21 January 2018

1 reference

Identifying targets for antibiotic development using omics technologies

21 January 2018

1 reference

SoNar, a Highly Responsive NAD /NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents

21 January 2018

1 reference

Metabolomics: a tool for anticancer lead-finding from natural products

21 January 2018

1 reference

External validation of multivariable prediction models: a systematic review of methodological conduct and reporting

21 January 2018

1 reference

Gender Dimorphism Creates Divergent Cancer Susceptibilities.

21 January 2018

1 reference

A network-based drug repositioning infrastructure for precision cancer medicine through targeting significantly mutated genes in the human cancer genomes.

21 January 2018

1 reference

Navigating cancer network attractors for tumor-specific therapy

21 January 2018

1 reference

Cancer: evolution within a lifetime

21 January 2018

1 reference

Cancer systems biology in the genome sequencing era: part 2, evolutionary dynamics of tumor clonal networks and drug resistance.

21 January 2018

1 reference

Clonal evolution in cancer

21 January 2018

1 reference

Why Your New Cancer Biomarker May Never Work: Recurrent Patterns and Remarkable Diversity in Biomarker Failures

21 January 2018

1 reference

Microtubule-stabilizing agents: New drug discovery and cancer therapy

21 January 2018

1 reference

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

21 January 2018

1 reference

Immunotherapy and Novel Combinations in Oncology: Current Landscape, Challenges, and Opportunities.

21 January 2018

1 reference

Perspective: The precision-oncology illusion

21 January 2018

1 reference

Benchmarking a Wide Range of Chemical Descriptors for Drug-Target Interaction Prediction Using a Chemogenomic Approach

21 January 2018

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.1002/MINF.201400066

8 April 2023

Identifiers

DOI

10.1093/BIB/BBX045

1 reference

6 September 2017

DBLP publication ID

journals/bib/FangLWLC18

1 reference

DBLP Dataset 2021-01-02

28 January 2021

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