SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase-Mediated Cytotoxicity and Reduces Cell Migration. (Q38781419)

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31 March 2020

title

SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase-Mediated Cytotoxicity and Reduces Cell Migration (English)

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8

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Antonio Giordano

13

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3

Iris Maria Forte

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12

Maurizio Botta

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Carmelina Antonella Iannuzzi

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6

object named as

Carmelina Antonella Iannuzzi

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Paola Indovina

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2

Nadia Casini

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11

Silvia Schenone

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author name string

Tiziana Garofano

4

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Daniele Cesari

5

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Leonardo Del Porro

7

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Luca Napoliello

9

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Silvia Boffo

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publication date

19 April 2016

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Journal of Cellular Physiology

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published in

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volume

232

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issue

1

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page(s)

129-135

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Inhibition of notch signaling induces neural differentiation in Ewing sarcoma

31 March 2020

cites work

1 reference

EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma

21 January 2018

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Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma

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Ewing's sarcoma family of tumors: current management

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The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation

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Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation.

21 January 2018

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SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation

21 January 2018

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SRC family kinase inhibition through a new pyrazolo[3,4-d]pyrimidine derivative as a feasible approach for glioblastoma treatment

21 January 2018

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Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition

21 January 2018

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The genomic landscape of pediatric Ewing sarcoma

21 January 2018

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Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression

21 January 2018

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Long-term survivors of childhood Ewing sarcoma: report from the childhood cancer survivor study

21 January 2018

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Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: a Children's Oncology Group Study.

21 January 2018

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Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone

21 January 2018

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Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma

21 January 2018

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New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization

21 January 2018

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Emerging roles of RB family: new defense mechanisms against tumor progression

21 January 2018

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RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy

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A molecular function map of Ewing's sarcoma

21 January 2018

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Notch signaling suppresses p38 MAPK activity via induction of MKP-1 in myogenesis

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Downstream EWS/FLI1 - upstream Ewing's sarcoma

21 January 2018

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Suppression of c-Src activity stimulates muscle differentiation via p38 MAPK activation

21 January 2018

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The Tyrosine Kinase c-Src Directly Mediates Growth Factor-Induced Notch-1 and Furin Interaction and Notch-1 Activation in Pancreatic Cancer Cells

21 January 2018

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p38MAPK-Dependent sensitivity of Ewing's sarcoma family of tumors to fenretinide-induced cell death

21 January 2018

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The sensitivity of the Ewing's sarcoma family of tumours to fenretinide-induced cell death is increased by EWS-Fli1-dependent modulation of p38(MAPK) activity

21 January 2018

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21 January 2018

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Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo.

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Notch signaling in pediatric soft tissue sarcomas

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New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation.

21 January 2018

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Novel dual Src/Abl inhibitors for hematologic and solid malignancies

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Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival

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Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells

21 January 2018

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Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations

21 January 2018

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CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-κB signaling

21 January 2018

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Fenretinide-dependent upregulation of death receptors through ASK1 and p38α enhances death receptor ligand-induced cell death in Ewing's sarcoma family of tumours

21 January 2018

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Basic fibroblast growth factor-induced cell death is effected through sustained activation of p38MAPK and up-regulation of the death receptor p75NTR.

21 January 2018

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Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group

21 January 2018

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Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration

21 January 2018

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SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis

21 January 2018

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21 January 2018

A renaissance for SRC

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21 January 2018

Identifiers

DOI

10.1002/JCP.25397

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31 March 2020

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