Pursuit of a perfect insulin. (Q38778988)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26988411 AND SRC:MED&resulttype=core&format=json

11 March 2020

title

Pursuit of a perfect insulin (English)

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11 March 2020

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1

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11 March 2020

author name string

John P Mayer

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26988411 AND SRC:MED&resulttype=core&format=json

11 March 2020

Richard D DiMarchi

series ordinal

3

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11 March 2020

publication date

18 March 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26988411 AND SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

11 March 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26988411 AND SRC:MED&resulttype=core&format=json

11 March 2020

volume

15

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26988411 AND SRC:MED&resulttype=core&format=json

11 March 2020

issue

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26988411 AND SRC:MED&resulttype=core&format=json

11 March 2020

page(s)

425-439

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26988411 AND SRC:MED&resulttype=core&format=json

Expression in Escherichia coli of chemically synthesized genes for human insulin

11 March 2020

cites work

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Human insulin prepared by recombinant DNA techniques and native human insulin interact identically with insulin receptors

21 January 2018

1 reference

Human insulin from recombinant DNA technology

21 January 2018

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Use and out-of-pocket costs of insulin for type 2 diabetes mellitus from 2000 through 2010.

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Insulin therapy in people with type 2 diabetes: opportunities and challenges?

21 January 2018

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PEGylated insulin Lispro, (LY2605541)--a new basal insulin analogue

21 January 2018

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Insulin degludec: overview of a novel ultra long-acting basal insulin

21 January 2018

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Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog.

21 January 2018

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Engineering of Insulin Receptor Isoform-Selective Insulin Analogues

21 January 2018

1 reference

One-year efficacy and safety of a fixed combination of insulin degludec and liraglutide in patients with type 2 diabetes: results of a 26-week extension to a 26-week main trial

21 January 2018

1 reference

Closed-loop insulin delivery: from bench to clinical practice

21 January 2018

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Emerging micro- and nanotechnology based synthetic approaches for insulin delivery

21 January 2018

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Insulin structure and function

21 January 2018

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Oral administration of insulin by encapsulation within liposomes

21 January 2018

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Oral insulin delivery: how far are we?

21 January 2018

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Inhaled insulin: a breath of fresh air? A review of inhaled insulin

21 January 2018

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Insulin pumps: from inception to the present and toward the future

21 January 2018

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The amino-acid sequence in the phenylalanyl chain of insulin. 2. The investigation of peptides from enzymic hydrolysates

21 January 2018

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The amino-acid sequence in the phenylalanyl chain of insulin. I. The identification of lower peptides from partial hydrolysates

21 January 2018

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Rewriting medical history: Charles Best and the Banting and Best myth

21 January 2018

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Insulin Peptides. X. The Synthesis of the B-Chain of Insulin and Its Combination with Natural or Synthetic A-Chain to Generate Insulin Activity

21 January 2018

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The synthesis of bovine insulin by the solid phase method

21 January 2018

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Secretion and processing of insulin precursors in yeast

21 January 2018

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

21 January 2018

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Insulin aspart vs. human insulin in the management of long-term blood glucose control in Type 1 diabetes mellitus: a randomized controlled trial.

21 January 2018

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Improved glycemic control with insulin aspart: a multicenter randomized double-blind crossover trial in type 1 diabetic patients. UK Insulin Aspart Study Group.

21 January 2018

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Clinical pharmacokinetics and pharmacodynamics of insulin glulisine

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Insulin glulisine, a new rapid-acting insulin analogue, displays a rapid time-action profile in obese non-diabetic subjects

21 January 2018

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Efficacy and safety of insulin glulisine in patients with type 1 diabetes

21 January 2018

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Basal insulin analogues in the management of diabetes mellitus: What progress have we made?

21 January 2018

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Newer insulin analogs: advances in basal insulin replacement

21 January 2018

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Pancreatic beta-cell growth and diabetes mellitus

21 January 2018

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Basal insulin therapy in type 2 diabetes: 28-week comparison of insulin glargine (HOE 901) and NPH insulin

21 January 2018

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NovoSol Basal: pharmacokinetics of a novel soluble long acting insulin analogue

21 January 2018

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Short-term intensive therapy in newly diagnosed type 2 diabetes partially restores both insulin sensitivity and β-cell function in subjects with long-term remission

21 January 2018

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Short-term intensified insulin treatment in type 2 diabetes: long-term effects on β-cell function

21 January 2018

1 reference

Variability of glucose-lowering effect as a limiting factor in optimizing basal insulin therapy: a review

21 January 2018

1 reference

Better glycemic control and weight loss with the novel long-acting basal insulin LY2605541 compared with insulin glargine in type 1 diabetes: a randomized, crossover study

21 January 2018

1 reference

Timing of meal insulin boluses to achieve optimal postprandial glycemic control in patients with type 1 diabetes

21 January 2018

1 reference

Closed-loop system in the management of diabetes: past, present, and future.

21 January 2018

1 reference

Protein engineering of insulin: Two novel fast-acting insulins [B16Ala]insulin and [B26Ala]insulin.

21 January 2018

1 reference

Design of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONS

21 January 2018

1 reference

Development of a long-acting insulin analog using albumin fusion technology

21 January 2018

1 reference

Discovery of high potency, single-chain insulin analogs with a shortened B-chain and nonpeptide linker

21 January 2018

1 reference

Proinsulin-transferrin fusion protein as a novel long-acting insulin analog for the inhibition of hepatic glucose production

21 January 2018

1 reference

Insulin fibrillation and protein design: topological resistance of single-chain analogs to thermal degradation with application to a pump reservoir

21 January 2018

1 reference

Hepatic Removal of Insulin in Normal Man: Dose Response to Endogenous Insulin Secretion*

21 January 2018

1 reference

Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans

21 January 2018

1 reference

Abnormal renal, hepatic, and muscle glucose metabolism following glucose ingestion in type 2 diabetes

21 January 2018

1 reference

The effect of portal and peripheral insulin delivery on carbohydrate and lipid metabolism in a miniature pig model of human IDDM

21 January 2018

1 reference

Comparison between closed-loop portal and peripheral venous insulin delivery systems for an artificial endocrine pancreas

21 January 2018

1 reference

Hepatoselectivity and the evolution of insulin

21 January 2018

1 reference

Insulin's direct effects on the liver dominate the control of hepatic glucose production

21 January 2018

1 reference

Differential effects of insulin detemir and neutral protamine Hagedorn (NPH) insulin on hepatic glucose production and peripheral glucose uptake during hypoglycaemia in type 1 diabetes

21 January 2018

1 reference

Basal insulin peglispro demonstrates preferential hepatic versus peripheral action relative to insulin glargine in healthy subjects.

21 January 2018

1 reference

Alternative splicing of human insulin receptor messenger RNA.

21 January 2018

1 reference

Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.

21 January 2018

1 reference

Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man.

21 January 2018

1 reference

Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

21 January 2018

1 reference

Receptor-isoform-selective insulin analogues give tissue-preferential effects

21 January 2018

1 reference

Signalling by insulin and IGF receptors: supporting acts and new players

21 January 2018

1 reference

Alternative routes of insulin delivery

21 January 2018

1 reference

Current challenges in non-invasive insulin delivery systems: a comparative review

21 January 2018

1 reference

21 January 2018

1 reference

Oral insulin - a review of current status

21 January 2018

1 reference

Technosphere insulin: an inhaled prandial insulin product

21 January 2018

1 reference

Glucose-reducing effect of the ORMD-0801 oral insulin preparation in patients with uncontrolled type 1 diabetes: a pilot study

21 January 2018

1 reference

Organization of Glucose-Responsive Systems and Their Properties

21 January 2018

1 reference

Responsive materials for self-regulated insulin delivery

21 January 2018

1 reference

Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates

21 January 2018

1 reference

Reversible insulin self-assembly under carbohydrate control

21 January 2018

1 reference

The role of basal insulin and glucagon-like peptide-1 agonists in the therapeutic management of type 2 diabetes--a comprehensive review

21 January 2018

1 reference

Combining incretin-based therapies with insulin: realizing the potential in type 2 diabetes

21 January 2018

1 reference

Combination therapy with GLP-1 receptor agonists and basal insulin: a systematic review of the literature

21 January 2018

1 reference

Combining GLP-1 receptor agonists with insulin: therapeutic rationales and clinical findings

21 January 2018

1 reference

Biology of incretins: GLP-1 and GIP

21 January 2018

1 reference

Advancing basal insulin replacement in type 2 diabetes inadequately controlled with insulin glargine plus oral agents: a comparison of adding albiglutide, a weekly GLP-1 receptor agonist, versus thrice-daily prandial insulin lispro

21 January 2018

1 reference

The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype

21 January 2018

1 reference

Inhibition of gastric inhibitory polypeptide signaling prevents obesity

21 January 2018

1 reference

GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis

21 January 2018

1 reference

Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties.

21 January 2018

1 reference

Cell factories for insulin production

21 January 2018

1 reference

Chemical synthesis of insulin analogs through a novel precursor

21 January 2018

1 reference

Therapeutic insulins and their large-scale manufacture

21 January 2018

1 reference

Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography

21 January 2018

1 reference

Design and folding of [GluA4(ObetaThrB30)]insulin ("ester insulin"): a minimal proinsulin surrogate that can be chemically converted into human insulin

21 January 2018

1 reference

Total synthesis of desB30 insulin analogues by biomimetic folding of single-chain precursors

21 January 2018

1 reference

Identification of a small molecular insulin receptor agonist with potent antidiabetes activity

21 January 2018

1 reference

A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control

21 January 2018

1 reference

Differential pathway coupling of the activated insulin receptor drives signaling selectivity by XMetA, an allosteric partial agonist antibody

21 January 2018

1 reference

Assembly of high-affinity insulin receptor agonists and antagonists from peptide building blocks

21 January 2018

1 reference

Agonism and antagonism at the insulin receptor

21 January 2018

1 reference

Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses

21 January 2018

1 reference

Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation

21 January 2018

1 reference

A 7-year follow-up retrospective, international, multicenter study of insulin pump therapy in children and adolescents with type 1 diabetes

21 January 2018

1 reference

Diabetes: insulin pump therapy for type 2 diabetes mellitus.

21 January 2018

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Insulin-pump therapy for type 1 diabetes mellitus

21 January 2018

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The use of stem cells for pancreatic regeneration in diabetes mellitus

21 January 2018

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Generation of functional human pancreatic β cells in vitro

21 January 2018

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Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering

21 January 2018

1 reference

Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery

21 January 2018

1 reference

Bariatric surgery versus intensive medical therapy in obese patients with diabetes

21 January 2018

1 reference

Anti-obesity drugs: past, present and future

21 January 2018

1 reference

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects

21 January 2018

1 reference

An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice

21 January 2018

1 reference

The role of leptin in glucose homeostasis

21 January 2018

1 reference

The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options

21 January 2018

1 reference

Practical aspects of insulin pen devices

21 January 2018

1 reference

Oral insulin reloaded: a structured approach

21 January 2018

1 reference

Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin.

21 January 2018

1 reference

Insulin degludec as an ultralong-acting basal insulin once a day: a systematic review

21 January 2018

1 reference

Elderly patients with diabetes experience a lower rate of nocturnal hypoglycaemia with insulin degludec than with insulin glargine: a meta-analysis of phase IIIa trials

21 January 2018

1 reference

Lower glucose variability and hypoglycemia measured by continuous glucose monitoring with novel long-acting insulin LY2605541 versus insulin glargine.

21 January 2018

1 reference

Contrasting weight changes with LY2605541, a novel long-acting insulin, and insulin glargine despite similar improved glycaemic control in T1DM and T2DM.

21 January 2018

1 reference

Insulin across respiratory mucosae by aerosol delivery

21 January 2018

1 reference

Ultrasound-mediated transdermal transport of insulin in vitro through human skin using novel transducer designs.

21 January 2018

1 reference

Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with typ

21 January 2018

1 reference

Superior glycaemic control with once-daily insulin degludec/insulin aspart versus insulin glargine in Japanese adults with type 2 diabetes inadequately controlled with oral drugs: a randomized, controlled phase 3 trial

21 January 2018

1 reference

Comparison of insulin degludec/insulin aspart and biphasic insulin aspart 30 in uncontrolled, insulin-treated type 2 diabetes: a phase 3a, randomized, treat-to-target trial

21 January 2018

1 reference

Insulin degludec/insulin aspart administered once daily at any meal, with insulin aspart at other meals versus a standard basal-bolus regimen in patients with type 1 diabetes: a 26-week, phase 3, randomized, open-label, treat-to-target trial

21 January 2018

1 reference

The Mechanism of Protraction of Insulin Detemir, a Long-Acting, Acylated Analog of Human Insulin

21 January 2018

1 reference

Monomeric insulins obtained by protein engineering and their medical implications

21 January 2018

1 reference

Synthesis: A constructive debate

21 January 2018

1 reference

A 26-Week, Randomized, Parallel, Treat-to-Target Trial Comparing Insulin Detemir With NPH Insulin as Add-On Therapy to Oral Glucose-Lowering Drugs in Insulin-Naive People With Type 2 Diabetes

21 January 2018

1 reference

21 January 2018

1 reference

Zinc insulin preparations for single daily injection; clinical studies of new preparations with prolonged action

31 March 2020

1 reference

31 March 2020

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A history of blood glucose meters and their role in self-monitoring of diabetes mellitus

31 March 2020

2 references

31 March 2020

12 December 2020

Human insulin: facile synthesis by modification of porcine insulin

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[Lys(B28), Pro(B29)]-human insulin. A rapidly absorbed analogue of human insulin

31 March 2020

1 reference

Pharmacokinetics, pharmacodynamics and glucose counterregulation following subcutaneous injection of the monomeric insulin analogue [Lys(B28),Pro(B29)] in IDDM

31 March 2020

1 reference

Improved mealtime treatment of diabetes mellitus using an insulin analogue. Multicenter Insulin Lispro Study Group

31 March 2020

1 reference

Combined Use of Regular and Crystalline Protamine (NPH) Insulins in the Treatment of Severe Diabetes

31 March 2020

1 reference

C-Peptide as a Measure of the Secretion and Hepatic Extraction of Insulin: Pitfalls and Limitations

31 March 2020

1 reference

Mechanism of action of insulin and insulin analogues. A comparison of the hepatic and peripheral effects on glucose turnover of insulin, proinsulin and three insulin analogues modified at positions A1 and B29

31 March 2020

1 reference

In vivo deactivation of proinsulin action on glucose disposal and hepatic glucose production in normal man

31 March 2020

1 reference

Novel hepatoselective insulin analog: studies with a covalently linked thyroxyl-insulin complex in humans

31 March 2020

1 reference

Insulin pens and new ways of insulin delivery

31 March 2020

1 reference

Sanofi to propel inhalable insulin Afrezza into market

31 March 2020

1 reference

Prandial inhaled insulin plus basal insulin glargine versus twice daily biaspart insulin for type 2 diabetes: a multicentre randomised trial

31 March 2020

1 reference

A comparison of adding liraglutide versus a single daily dose of insulin aspart to insulin degludec in subjects with type 2 diabetes (BEGIN: VICTOZA ADD-ON)

31 March 2020

1 reference

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

31 March 2020

1 reference

Concise synthetic routes to human insulin

31 March 2020

1 reference

A synthetic route to human insulin using isoacyl peptides

31 March 2020

1 reference

Can diabetes be surgically cured? Long-term metabolic effects of bariatric surgery in obese patients with type 2 diabetes mellitus

31 March 2020

1 reference

Single-dose pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 in healthy subjects

31 March 2020

1 reference

Total synthesis of crystalline bovine insulin

31 March 2020

1 reference

12 December 2020

Backbone cyclic insulin

1 reference

12 December 2020

Insulin therapy for management of type 2 diabetes mellitus: strategies for initiation and long-term patient adherence

1 reference

12 December 2020

Hypoglycemia in the Diabetes Control and Complications Trial. The Diabetes Control and Complications Trial Research Group

1 reference

12 December 2020

Comparison of sub-chronic metabolic effects of stable forms of naturally occurring GIP(1-30) and GIP(1-42) in high-fat fed mice

1 reference

12 December 2020

Functionally distinct insulin receptors generated by tissue-specific alternative splicing

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD.2015.36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26988411 AND SRC:MED&resulttype=core&format=json

11 March 2020

1 reference