2-hydroxyoestradiol and 2-methoxyoestradiol, two endogenous oestradiol metabolites, induce DNA fragmentation in Sertoli cells (Q38778817)

6 September 2017

title

2-hydroxyoestradiol and 2-methoxyoestradiol, two endogenous oestradiol metabolites, induce DNA fragmentation in Sertoli cells (English)

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6 September 2017

5

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3 June 2020

Alexis Parada-Bustamante

8

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3 June 2020

author name string

C Valencia

1

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3 June 2020

C Molina

2

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3 June 2020

M Florez

3

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3 June 2020

J Buñay

4

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3 June 2020

P A Orihuela

6

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3 June 2020

A Castro

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3 June 2020

publication date

13 April 2016

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6 September 2017

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3 June 2020

volume

48

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issue

10

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3 June 2020

page(s)

1294-1306

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On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid.

3 June 2020

cites work

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Estrogenic regulation of bicarbonate transporters from SLC4 family in rat Sertoli cells

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Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells

21 January 2018

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4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-kappaB and ERK/MAPK.

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Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells

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Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues

21 January 2018

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The catecholestrogen, 2-hydroxyestradiol-17beta, acts as a G protein-coupled estrogen receptor 1 (GPER/GPR30) antagonist to promote the resumption of meiosis in zebrafish oocytes.

21 January 2018

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In vitro model of mammary estrogen metabolism: structural and kinetic differences between catechol estrogens 2- and 4-hydroxyestradiol

21 January 2018

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CYP1B1 expression in rat testis and Leydig cells is not inducible by aryl hydrocarbon receptor agonists

21 January 2018

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Estradiol metabolites inhibit endothelin synthesis by an estrogen receptor-independent mechanism

21 January 2018

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Effects of 3,3',4,4',5-pentachlorobiphenyl, a coplanar polychlorinated biphenyl congener, on cultured neonatal mouse testis

21 January 2018

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Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells

21 January 2018

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2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells

21 January 2018

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2-methoxyestradiol mediates apoptosis through caspase-dependent and independent mechanisms in ovarian cancer cells but not in normal counterparts

21 January 2018

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Cell lines: Valuable tools or useless artifacts

21 January 2018

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2-Methoxyestradiol in the human corpus luteum throughout the luteal phase and its influence on lutein cell steroidogenesis and angiogenic activity

21 January 2018

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Developmental expression and endocrine regulation of CYP1B1 in rat testis

21 January 2018

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Oestradiol regulation of the components of the plasminogen-plasmin system in MDA-MB-231 human breast cancer cells stably expressing the oestrogen receptor

21 January 2018

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Cinnamaldehyde-induced apoptosis in human hepatoma PLC/PRF/5 cells involves the mitochondrial death pathway and is sensitive to inhibition by cyclosporin A and z-VAD-fmk

21 January 2018

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Selective insensitivity of ZR-75-1 human breast cancer cells to 2-methoxyestradiol: evidence for type II 17beta-hydroxysteroid dehydrogenase as the underlying cause

21 January 2018

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17β-estradiol signaling and regulation of Sertoli cell function

21 January 2018

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Testosterone attenuates morpho‐functional alterations by 2‐methoxyestradiol exposure and induces differentiation in C6 cells

21 January 2018

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2-methoxyestradiol inhibits differentiation and is cytotoxic to osteoclasts

21 January 2018

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Mechanism of action of 2-methoxyestradiol: new developments

21 January 2018

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Catechol estrogens induce proliferation and malignant transformation in prostate epithelial cells.

21 January 2018

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The role of 17beta-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells

21 January 2018

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Phosphorylated and non-phosphorylated forms of catechol O-methyltransferase in rat liver, brain and other tissues

21 January 2018

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Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease.

21 January 2018

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4-hydroxyestradiol induces anchorage-independent growth of human mammary epithelial cells via activation of IkappaB kinase: potential role of reactive oxygen species

21 January 2018

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Estrogen metabolism and breast cancer: a risk model.

21 January 2018

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Metabolic pathways involved in 2-methoxyestradiol synthesis and their role in preeclampsia

21 January 2018

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Sertoli cell as a model in male reproductive toxicology: Advantages and disadvantages

21 January 2018

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Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects sperm from DNA damage and apoptosis caused by benzo(a)pyrene

21 January 2018

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Serum LH correlates highly with intratesticular steroid levels in normal men

21 January 2018

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Regulation of catechol O-methyltransferase expression in granulosa cells: a potential role for follicular arrest in polycystic ovary syndrome

21 January 2018

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The chemistry and biological activities of N-acetylcysteine

21 January 2018

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Differential effects of caspase inhibitors on TNF-induced necroptosis

21 January 2018

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Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene

21 January 2018

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Evidence that 2-methoxyestradiol suppresses proliferation and accelerates apoptosis in normal rat growth plate chondrocytes

21 January 2018

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Regulation of apoptotic signaling pathways by 5α-dihydrotestosterone and 17β-estradiol in immature rat Sertoli cells

21 January 2018

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2-Methoxyestradiol--a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents

21 January 2018

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A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer

21 January 2018

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Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells.

21 January 2018

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Cytochrome P450-mediated metabolism of estrogens and its regulation in human.

21 January 2018

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Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges

21 January 2018

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Effect of allopurinol on damage caused by free radicals to cryptorchid testes

21 January 2018

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Maturation, proliferation and apoptosis of seminal tubule cells at puberty after administration of estradiol, follicle stimulating hormone or both

21 January 2018

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Estradiol and testosterone inhibit rat seminiferous tubule development in a hormone-specific way.

21 January 2018

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Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells

21 January 2018

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2-hydroxyestradiol is a prodrug of 2-methoxyestradiol

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/AND.12576

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27071496 AND SRC:MED&resulttype=core&format=json

3 June 2020

1 reference