Selected cytokine pathways in rheumatoid arthritis (Q38755912)

6 September 2017

title

Selected cytokine pathways in rheumatoid arthritis (English)

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6 September 2017

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Mélissa Noack

1

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6 September 2017

Pierre Miossec

series ordinal

2

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6 September 2017

publication date

17 February 2017

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Seminars in Immunopathology

6 September 2017

published in

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6 September 2017

volume

39

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6 September 2017

issue

4

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6 September 2017

page(s)

365-383

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Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

6 September 2017

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The role of IL-1β in the early tumor cell-induced angiogenic response.

21 January 2018

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Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis

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IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis

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21 January 2018

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Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain.

21 January 2018

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Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development.

21 January 2018

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Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils

21 January 2018

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Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells

21 January 2018

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Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling.

21 January 2018

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Polymorphism at position -308 of the tumour necrosis factor alpha gene and rheumatoid arthritis pharmacogenetics.

21 January 2018

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T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

21 January 2018

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IL-1 pathways in inflammation and human diseases

21 January 2018

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Recent advances in the IL-17 cytokine family

21 January 2018

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Structure and signalling in the IL-17 receptor family

21 January 2018

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21 January 2018

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21 January 2018

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Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate

21 January 2018

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One-year efficacy and safety results of secukinumab in patients with rheumatoid arthritis: phase II, dose-finding, double-blind, randomized, placebo-controlled study

21 January 2018

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21 January 2018

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21 January 2018

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Sarilumab Plus Methotrexate in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate: Results of a Phase III Study

21 January 2018

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A phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors

21 January 2018

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Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy

21 January 2018

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Colony-stimulating factors in inflammation and autoimmunity.

21 January 2018

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The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

21 January 2018

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IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17.

21 January 2018

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The Roles of Interleukin-6 in the Pathogenesis of Rheumatoid Arthritis

21 January 2018

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21 January 2018

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21 January 2018

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Blockade of TNF-α rapidly inhibits pain responses in the central nervous system

21 January 2018

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21 January 2018

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T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17 Th cells that cause autoimmune arthritis.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Circulating Ly-6C myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease.

21 January 2018

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Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort).

21 January 2018

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Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.

21 January 2018

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Secukinumab for rheumatology: development and its potential place in therapy

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Tumor necrosis factor α induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts

21 January 2018

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Infections in patients with rheumatoid arthritis treated with biologic agents

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction

21 January 2018

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Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion

21 January 2018

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Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis

21 January 2018

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Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity

21 January 2018

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Intracellular Signaling Pathways in Rheumatoid Arthritis

21 January 2018

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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

21 January 2018

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A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis

21 January 2018

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Rilonacept in the treatment of chronic inflammatory disorders

21 January 2018

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Cytokines in rheumatoid arthritis - shaping the immunological landscape

21 January 2018

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21 January 2018

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Targeting interleukin-6 in rheumatoid arthritis

21 January 2018

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Anakinra for rheumatoid arthritis: a systematic review

21 January 2018

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The colony-stimulating factors and cancer

21 January 2018

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21 January 2018

Hematopoietic cytokines

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Illuminating the black box of TNF action in tuberculous granulomas.

21 January 2018

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Anti-interleukin 1alpha autoantibodies

21 January 2018

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Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy

21 January 2018

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Targeting IL-17 and TH17 cells in chronic inflammation

21 January 2018

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Interleukin-17 and type 17 helper T cells

21 January 2018

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Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta

21 January 2018

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Sustained biologic-free and drug-free remission in rheumatoid arthritis, where are we now?

21 January 2018

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IL-1beta processing in host defense: beyond the inflammasomes

21 January 2018

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IL-6 is required for airway mucus production induced by inhaled fungal allergens

21 January 2018

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Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab

21 January 2018

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Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial

21 January 2018

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Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion

21 January 2018

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The STIR-domain superfamily in signal transduction, development and immunity

21 January 2018

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21 January 2018

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Interleukin 6 plays a key role in the development of antigen-induced arthritis

21 January 2018

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A study to evaluate the safety, tolerability, and efficacy of brodalumab in subjects with rheumatoid arthritis and an inadequate response to methotrexate

21 January 2018

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21 January 2018

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21 January 2018

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Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint

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GM-CSF neutralisation suppresses inflammation and protects cartilage in acute streptococcal cell wall arthritis of mice

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TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects

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The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease.

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Interleukin-1 function and role in rheumatic disease

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How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy

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Remission in rheumatoid arthritis: wishful thinking or clinical reality?

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GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1.

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Pivotal roles of GM-CSF in autoimmunity and inflammation

21 January 2018

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GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice

21 January 2018

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2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis

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21 January 2018

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21 January 2018

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Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy

21 January 2018

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Familial autoinflammatory diseases: genetics, pathogenesis and treatment

21 January 2018

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Hematopoietic colony-stimulating factors: new players in tumor–nerve interactions

21 January 2018

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21 January 2018

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21 January 2018

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IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression

21 January 2018

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IL-6 targeting compared to TNF targeting in rheumatoid arthritis: studies of olokizumab, sarilumab and sirukumab.

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The effect of gene polymorphisms on patient responses to rheumatoid arthritis therapy.

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Role of interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression

21 January 2018

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Role of IL-17 in the Th1 systemic defects in rheumatoid arthritis through selective IL-12Rbeta2 inhibition

21 January 2018

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Cutting edge: interleukin 17 signals through a heteromeric receptor complex

21 January 2018

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Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis

21 January 2018

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Interindividual and intra-articular variation of proinflammatory cytokines in patients with rheumatoid arthritis: potential implications for treatment.

21 January 2018

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A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection

21 January 2018

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GM-CSF as a therapeutic target in inflammatory diseases

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Complementary action of granulocyte macrophage colony-stimulating factor and interleukin-17A induces interleukin-23, receptor activator of nuclear factor-κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimenta

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The efficacy and safety of subcutaneous clazakizumab in patients with moderate-to-severe rheumatoid arthritis and an inadequate response to methotrexate: results from a multinational, phase IIb, randomized, double-blind, placebo/active-controlled, d

21 January 2018

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Targeting GM-CSF in inflammatory diseases

21 January 2018

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Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis

21 January 2018

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Cytokines in chronic inflammatory arthritis. II. Granulocyte-macrophage colony-stimulating factor in rheumatoid synovial effusions

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The response to anti-TNF-α treatment: gene regulation at the bedside

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Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts

21 January 2018

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Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain

21 January 2018

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Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor -independent mouse model

21 January 2018

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Evidence for GM-CSF receptor expression in synovial tissue. An analysis by semi-quantitative polymerase chain reaction on rheumatoid arthritis and osteoarthritis synovial biopsies

21 January 2018

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12 December 2020

The combination of tumor necrosis factor alpha blockade with interleukin-1 and interleukin-17 blockade is more effective for controlling synovial inflammation and bone resorption in an ex vivo model

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Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis

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Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130

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Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor

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12 December 2020

Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha

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Effects of Interleukin-17A on Osteogenic Differentiation of Isolated Human Mesenchymal Stem Cells

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Hematopoietic colony–stimulating factors mediate tumor-nerve interactions and bone cancer pain

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12 December 2020

Stimulus-dependent requirement for granulocyte-macrophage colony-stimulating factor in inflammation

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12 December 2020

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

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Classical and Paradoxical Effects of TNF-α on Bone Homeostasis

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Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis

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Tocilizumab in the treatment of rheumatoid arthritis and beyond

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12 December 2020

Altered susceptibility to collagen-induced arthritis in transgenic mice with aberrant expression of interleukin-1 receptor antagonist

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IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation.

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12 December 2020

Expression of GM-CSF receptor in rheumatoid arthritis

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12 December 2020

Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resolution of arthritis

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12 December 2020

Correction of granulocytopenia in Felty's syndrome by granulocyte-macrophage colony-stimulating factor. Simultaneous induction of interleukin-6 release and flare-up of the arthritis

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12 December 2020

Profile of cerebrospinal fluid and serum cytokines in patients with relapsing-remitting multiple sclerosis: a correlation with clinical activity

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12 December 2020

IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells

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12 December 2020

High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism

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12 December 2020

Angiogenesis in rheumatoid arthritis

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12 December 2020

Comparison of the in vivo inflammatory activities after intra-articular injection of natural and recombinant IL-1 alpha and IL-1 beta in the rabbit

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12 December 2020

Plasma GM-CSF concentrations in rheumatoid arthritis, systemic lupus erythematosus and spondyloarthropathy

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12 December 2020

Arthritis induced by interleukin-1 is dependent on the site and frequency of intraarticular injection

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12 December 2020

Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines.

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12 December 2020

Gevokizumab, an anti-IL-1β mAb for the potential treatment of type 1 and 2 diabetes, rheumatoid arthritis and cardiovascular disease

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12 December 2020

Flare-up of rheumatoid arthritis during GM-CSF treatment after chemotherapy

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12 December 2020

Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice

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12 December 2020

Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease

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12 December 2020

Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice

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12 December 2020

Dependence of interleukin-1-induced arthritis on granulocyte-macrophage colony-stimulating factor

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12 December 2020

Influence of a recombinant human soluble tumor necrosis factor receptor FC fusion protein on type II collagen-induced arthritis in mice

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12 December 2020

Interleukin-1 receptor antagonist inhibits proteoglycan breakdown in antigen induced but not polycation induced arthritis in the rabbit

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12 December 2020

IL-17 is a potent synergistic factor with GM-CSF in mice in stimulating myelopoiesis, dendritic cell expansion, proliferation, and functional enhancement

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12 December 2020

A phase II, double-blind, randomised, placebo-controlled study of BMS945429 (ALD518) in patients with rheumatoid arthritis with an inadequate response to methotrexate

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12 December 2020

High Levels of Neutralizing Autoantibodies Against IL‐1α are Associated with a Better Prognosis in Chronic Polyarthritis: a Follow‐Up Study

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12 December 2020

Cytokine regulation of colony-stimulating factor production in cultured human synovial fibroblasts: I. Induction of GM-CSF and G-CSF production by interleukin-1 and tumor necrosis factor

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Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial

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12 December 2020

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12 December 2020

Interleukin-6 (IL-6) induces the proliferation of synovial fibroblastic cells in the presence of soluble IL-6 receptor

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12 December 2020

The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation

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12 December 2020

Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses

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12 December 2020

Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis

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12 December 2020

Enhancing effect of IL-1, IL-17, and TNF-alpha on macrophage inflammatory protein-3alpha production in rheumatoid arthritis: regulation by soluble receptors and Th2 cytokines

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12 December 2020

Targeting interleukin-1 in the treatment of rheumatoid arthritis

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12 December 2020

Negative association between autoantibodies against IL-17, IL-17/anti-IL-17 antibody immune complexes and destruction in rheumatoid arthritis

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12 December 2020

Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation

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12 December 2020

Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist.

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12 December 2020

Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation

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A cell-based bioassay for circulating bioactive IL-17: application to destruction in rheumatoid arthritis

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Recombinant human interleukin-1 receptor type I in the treatment of patients with active rheumatoid arthritis

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12 December 2020

Serum and synovial fluid levels of interleukin-17 in correlation with disease activity in patients with RA

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12 December 2020

Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis

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12 December 2020

Arthritis induced by continuous infusion of hr-interleukin-1 alpha into the rabbit knee-joint.

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12 December 2020

Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

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Major role for interleukin 1 but not for tumor necrosis factor in early cartilage damage in immune complex arthritis in mice

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12 December 2020

Measurement of colony-stimulating factors in synovial fluid: potential clinical value

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12 December 2020

Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis

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12 December 2020

Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis

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12 December 2020

GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis

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12 December 2020

Human articular cartilage and chondrocytes produce hemopoietic colony-stimulating factors in culture in response to IL-1

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12 December 2020

IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood

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12 December 2020

Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial

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The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis

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10.1007/S00281-017-0619-Z

Identifiers

DOI

1 reference

Dimensions Publication ID

6 September 2017

1083847850

0 references

1 reference