Voltage-gated sodium channel Nav 1.7 promotes gastric cancer progression through MACC1-mediated upregulation of NHE1. (Q38751561)

6 September 2017

title

Voltage-gated sodium channel Nav 1.7 promotes gastric cancer progression through MACC1-mediated upregulation of NHE1. (English)

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6 September 2017

Jianling Xia

1

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6 September 2017

Na Huang

2

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6 September 2017

Hongxiang Huang

3

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6 September 2017

Li Sun

4

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6 September 2017

Shaoting Dong

5

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6 September 2017

Jinyu Su

6

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6 September 2017

Jingwen Zhang

7

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6 September 2017

Lin Wang

8

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6 September 2017

Li Lin

9

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6 September 2017

Min Shi

10

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6 September 2017

Jianping Bin

11

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6 September 2017

Yulin Liao

12

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6 September 2017

Nailin Li

13

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6 September 2017

Wangjun Liao

14

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6 September 2017

language of work or name

English

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publication date

16 August 2016

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International Journal of Cancer

6 September 2017

published in

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6 September 2017

volume

139

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6 September 2017

issue

11

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6 September 2017

page(s)

2553-2569

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6 September 2017

cites work

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Voltage-gated Na channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion

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NHE-1: a molecular target for signalling and cell matrix interactions

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Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H⁺ extrusion, cell migration and survival.

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Coordinated role of voltage-gated sodium channels and the Na /H exchanger in sustaining microglial activation during inflammation.

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Metastasis-associated in colon cancer-1 upregulation predicts a poor prognosis of gastric cancer, and promotes tumor cell proliferation and invasion

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Metastasis-associated in colon cancer-1 promotes vasculogenic mimicry in gastric cancer by upregulating TWIST1/2.

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MACC1 supports human gastric cancer growth under metabolic stress by enhancing the Warburg effect

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Effects and mechanisms of proton pump inhibitors as a novel chemosensitizer on human gastric adenocarcinoma (SGC7901) cells

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Down-regulation of P-glycoprotein expression by sustained intracellular acidification in K562/Dox cells

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Down-regulation of the P-glycoprotein relevant for multidrug resistance by intracellular acidification through the crosstalk of MAPK signaling pathways

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(E)-2,4-bis(p-hydroxyphenyl)-2-butenal has an antiproliferative effect on NSCLC cells induced by p38 MAPK-mediated suppression of NF-κB and up-regulation of TNFRSF10B (DR5).

21 January 2018

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MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis

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Hepatocyte growth factor increases osteopontin expression in human osteoblasts through PI3K, Akt, c-Src, and AP-1 signaling pathway

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FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells

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ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex

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Membrane potential and cancer progression

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Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell lines

21 January 2018

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Functional expression of the voltage-gated Na⁺-channel Nav1.7 is necessary for EGF-mediated invasion in human non-small cell lung cancer cells

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Ranolazine inhibits NaV1.5-mediated breast cancer cell invasiveness and lung colonization

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Na(V)1.5 enhances breast cancer cell invasiveness by increasing NHE1-dependent H( ) efflux in caveolae

21 January 2018

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NaV1.5 Na⁺ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodia

21 January 2018

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Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: clinical potential of neonatal Nav1.5 in breast cancer

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Voltage-gated Na Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling

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Overexpression of NaV 1.6 channels is associated with the invasion capacity of human cervical cancer

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Suppression of PPARβ, and DHA treatment, inhibit NaV1.5 and NHE-1 pro-invasive activities.

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Signal transduction in cancer

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c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma

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NDRG2 suppresses cell proliferation through down-regulation of AP-1 activity in human colon carcinoma cells

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Opposite effects of JNK and p38 MAPK signaling pathways on furazolidone-stimulated S phase cell cycle arrest of human hepatoblastoma cell line

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.30381

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6 September 2017

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