Substrate stiffness-dependent regulation of the SRF-Mkl1 co-activator complex requires the inner nuclear membrane protein Emerin. (Q38747463)

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22 March 2020

title

Substrate stiffness-dependent regulation of the SRF-Mkl1 co-activator complex requires the inner nuclear membrane protein Emerin (English)

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22 March 2020

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Christopher W Carroll

series ordinal

2

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22 March 2020

author name string

Margaret K Willer

series ordinal

1

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22 March 2020

language of work or name

English

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publication date

2 June 2017

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22 March 2020

published in

Journal of Cell Science

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volume

130

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issue

13

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page(s)

2111-2118

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describes a project that uses

22 March 2020

ImageJ

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11 June 2022

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cites work

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Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes

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RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding

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Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics

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An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture.

21 January 2018

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Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane

21 January 2018

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Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

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Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

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Nuclear transport of the serum response factor coactivator MRTF-A is downregulated at tensional homeostasis

21 January 2018

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Actin dynamics control SRF activity by regulation of its coactivator MAL

21 January 2018

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Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator

21 January 2018

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Matrix Rigidity Mediates TGFβ1-Induced Epithelial-Myofibroblast Transition by Controlling Cytoskeletal Organization and MRTF-A Localization.

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Hic-5 is required for myofibroblast differentiation by regulating mechanically dependent MRTF-A nuclear accumulation

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Identifiers

DOI

10.1242/JCS.197517

1 reference

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22 March 2020

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22 March 2020

PubMed publication ID

28576971

1 reference