Quantification of IgG monoclonal antibody clearance in tissues (Q38726179)

http://europepmc.org/abstract/PMC/5540074

26 June 2018

title

Quantification of IgG monoclonal antibody clearance in tissues (English)

1 reference

http://europepmc.org/abstract/PMC/5540074

26 June 2018

1 reference

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28613103 AND SRC:MED&resulttype=core&format=json

Ben-Fillippo Krippendorff

31 May 2020

5

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31 May 2020

author name string

Miro J Eigenmann

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28613103 AND SRC:MED&resulttype=core&format=json

31 May 2020

Ludivine Fronton

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28613103 AND SRC:MED&resulttype=core&format=json

31 May 2020

Michael B Otteneder

4

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31 May 2020

publication date

14 June 2017

1 reference

http://europepmc.org/abstract/PMC/5540074

26 June 2018

published in

Monoclonal Antibodies

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28613103 AND SRC:MED&resulttype=core&format=json

31 May 2020

volume

9

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31 May 2020

issue

6

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31 May 2020

page(s)

1007-1015

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28613103 AND SRC:MED&resulttype=core&format=json

Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice

31 May 2020

cites work

1 reference

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The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies

30 June 2018

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Pharmacokinetic characteristics of therapeutic antibodies

30 June 2018

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30 June 2018

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Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor

30 June 2018

1 reference

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The effect of the neonatal Fc receptor on human IgG biodistribution in mice

30 June 2018

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Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics

30 June 2018

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Antibody biodistribution coefficients: inferring tissue concentrations of monoclonal antibodies based on the plasma concentrations in several preclinical species and human

30 June 2018

1 reference

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Evaluation of a catenary PBPK model for predicting the in vivo disposition of mAbs engineered for high-affinity binding to FcRn

30 June 2018

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Physiologically based pharmacokinetic model for T84.66: a monoclonal anti-CEA antibody

30 June 2018

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The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity

30 June 2018

1 reference

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Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5540074

Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

30 June 2018

1 reference

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Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism

30 June 2018

1 reference

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FcRn: the neonatal Fc receptor comes of age.

30 June 2018

1 reference

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Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5540074

Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5540074

The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan

30 June 2018

1 reference

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Physiological Parameter Values for Physiologically Based Pharmacokinetic Models

30 June 2018

1 reference

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Transport of macromolecules across microvascular walls: the two-pore theory

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5540074

Identification of metabolites of 111In-diethylenetriaminepentaacetic acid-monoclonal antibodies and antibody fragments in vivo.

30 June 2018

1 reference

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Metabolism of immunoglobulins

30 June 2018

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Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

30 June 2018

1 reference

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A two-tiered physiologically based model for dually labeled single-chain Fv-Fc antibody fragments.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5540074

A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn).

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5540074

Metabolism and renal clearance of 111In-labeled DOTA-conjugated antibody fragments

31 August 2018

1 reference

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In vivo trafficking and catabolism of IgG1 antibodies with Fc associated carbohydrates of differing structure

31 August 2018

1 reference

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Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice.

31 August 2018

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Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.

31 August 2018

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Comparative metabolism and retention of iodine-125, yttrium-90, and indium-111 radioimmunoconjugates by cancer cells

31 August 2018

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12 December 2020

Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans

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12 December 2020

Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice

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12 December 2020

Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice

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12 December 2020

Identification of the sites of IgG catabolism in the rat

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12 December 2020

Monoclonal antibodies directed against Fpr3 protein as molecular chaperones

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12 December 2020

Physiological parameters in laboratory animals and humans

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12 December 2020

10.1080/19420862.2017.1337619

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28613103 AND SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28613103 AND SRC:MED&resulttype=core&format=json

31 May 2020

PubMed publication ID

28613103

1 reference