Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils. (Q38722643)

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23 March 2020

title

Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils (English)

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23 March 2020

5

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23 March 2020

author name string

J Mario Isas

1

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23 March 2020

Andreas Langen

2

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23 March 2020

Myles C Isas

3

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23 March 2020

Nitin K Pandey

4

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23 March 2020

language of work or name

English

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publication date

7 July 2017

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23 March 2020

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23 March 2020

volume

56

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23 March 2020

issue

28

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23 March 2020

page(s)

3579-3586

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Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core

23 March 2020

cites work

1 reference

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Backbone Engineering within a Latent β-Hairpin Structure to Design Inhibitors of Polyglutamine Amyloid Formation

4 November 2018

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Huntingtin exon 1 fibrils feature an interdigitated β-hairpin-based polyglutamine core

4 November 2018

1 reference

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A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast.

4 November 2018

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Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin

4 November 2018

1 reference

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Solid-State Nuclear Magnetic Resonance on the Static and Dynamic Domains of Huntingtin Exon-1 Fibrils

4 November 2018

1 reference

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Polyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state nuclear magnetic resonance.

4 November 2018

1 reference

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Monomeric, oligomeric and polymeric proteins in huntington disease and other diseases of polyglutamine expansion

4 November 2018

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Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

4 November 2018

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Structural features and domain organization of huntingtin fibrils

4 November 2018

1 reference

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Fibrillar α-synuclein and huntingtin exon 1 assemblies are toxic to the cells

4 November 2018

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CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.

4 November 2018

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Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments.

4 November 2018

1 reference

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Structural characterization of polyglutamine fibrils by solid-state NMR spectroscopy

4 November 2018

1 reference

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The Aggregation-Enhancing Huntingtin N-Terminus Is Helical in Amyloid Fibrils

4 November 2018

1 reference

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Single homopolypeptide chains collapse into mechanically rigid conformations

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5575822

Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity

4 November 2018

1 reference

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Fibrils with parallel in-register structure constitute a major class of amyloid fibrils: molecular insights from electron paramagnetic resonance spectroscopy

4 November 2018

1 reference

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Further conventions for NMR shielding and chemical shifts (IUPAC Recommendations 2008).

4 November 2018

1 reference

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Alanine scanning mutagenesis of Abeta(1-40) amyloid fibril stability

4 November 2018

1 reference

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Diseases of unstable repeat expansion: mechanisms and common principles

4 November 2018

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Thermodynamics of A beta(1-40) amyloid fibril elongation

4 November 2018

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New model for crystalline polyglutamine assemblies and their connection with amyloid fibrils

4 November 2018

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Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease

4 November 2018

1 reference

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Amyloid fibers are water-filled nanotubes

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5575822

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5575822

10.1021/ACS.BIOCHEM.7B00138

4 November 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522 AND SRC:MED&resulttype=core&format=json

23 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28621522 AND SRC:MED&resulttype=core&format=json

23 March 2020

PubMed publication ID

28621522

1 reference