Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches (Q38704618)

5 September 2017

title

Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches (English)

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5 September 2017

main subject

neoplastic stem cells

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Antonio Giordano

4

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Antonio Gasbarrini

5

object named as

Antonio Gasbarrini

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5 September 2017

author name string

Angela Maria Di Francesco

1

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5 September 2017

Amelia Toesca

2

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5 September 2017

Carlo Cenciarelli

3

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5 September 2017

Maria Ausiliatrice Puglisi

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5 September 2017

publication date

21 January 2016

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Journal of Cellular Physiology

5 September 2017

published in

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5 September 2017

volume

231

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5 September 2017

issue

10

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5 September 2017

page(s)

2081-2087

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Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells

5 September 2017

cites work

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Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target.

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Inflammation meets cancer, with NF-κB as the matchmaker

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Innovation in metabolomics to improve personalized healthcare

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Regulation of cancer cell metabolism

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CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.

21 January 2018

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Upregulation of mitochondrial function and antioxidant defense in the differentiation of stem cells.

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Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells

21 January 2018

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Metformin inhibits the proliferation, metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cells in vitro

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From cancer metabolism to new biomarkers and drug targets

21 January 2018

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Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners

21 January 2018

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The Enhanced metastatic potential of hepatocellular carcinoma (HCC) cells with sorafenib resistance

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ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-kB-dependent activation of Snail

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Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K.

21 January 2018

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Carbonic Anhydrase 9 mRNA/microRNA34a Interplay in Hypoxic Human Mammospheres

21 January 2018

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

21 January 2018

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Metabolomic profile in pancreatic cancer patients: a consensus-based approach to identify highly discriminating metabolites

21 January 2018

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

21 January 2018

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Redox Regulation in Cancer Stem Cells

21 January 2018

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Glutathione in cancer biology and therapy

21 January 2018

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Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2

21 January 2018

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Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay

21 January 2018

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EMT and oxidative stress: a bidirectional interplay affecting tumor malignancy

21 January 2018

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Low concentrations of metformin selectively inhibit CD133⁺ cell proliferation in pancreatic cancer and have anticancer action

21 January 2018

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Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

21 January 2018

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MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer

21 January 2018

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Metformin suppressed the proliferation of LoVo cells and induced a time-dependent metabolic and transcriptional alteration

21 January 2018

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Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

21 January 2018

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Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

21 January 2018

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Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression

21 January 2018

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Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis

21 January 2018

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Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types

21 January 2018

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CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth

21 January 2018

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Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

21 January 2018

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Concise review: the role of oxygen in hematopoietic stem cell physiology

21 January 2018

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Glutaminolysis as a target for cancer therapy

21 January 2018

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Prisoner's Dilemma in Cancer Metabolism

21 January 2018

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Verification of ALDH Activity as a Biomarker in Colon Cancer Stem Cells-Derived HT-29 Cell Line

21 January 2018

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Sensitization of chemo-resistant human chronic myeloid leukemia stem-like cells to Hsp90 inhibitor by SIRT1 inhibition.

21 January 2018

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

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Regulation of reactive oxygen species in stem cells and cancer stem cells.

21 January 2018

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SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells

21 January 2018

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Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway.

21 January 2018

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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

21 January 2018

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Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

21 January 2018

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Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness

21 January 2018

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SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma

21 January 2018

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Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment

21 January 2018

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Physiologic oxygen concentration enhances the stem-like properties of CD133 human glioblastoma cells in vitro.

21 January 2018

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Metabostemness: a new cancer hallmark.

21 January 2018

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The Warburg effect version 2.0: metabolic reprogramming of cancer stem cells

21 January 2018

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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

21 January 2018

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Metformin: a potential therapeutic agent for recurrent colon cancer

21 January 2018

1 reference

Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo

21 January 2018

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Sirtuins' modulation of autophagy

21 January 2018

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LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1α and Stat3 Signaling

21 January 2018

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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

21 January 2018

1 reference

Tumor initiating cells and chemoresistance: which is the best strategy to target colon cancer stem cells?

21 January 2018

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Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels

21 January 2018

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Gemcitabine response in pancreatic adenocarcinoma cells is synergistically enhanced by dithiocarbamate derivatives.

21 January 2018

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High nitric oxide production, secondary to inducible nitric oxide synthase expression, is essential for regulation of the tumour-initiating properties of colon cancer stem cells.

21 January 2018

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Colon cancer stem cells: controversies and perspectives

21 January 2018

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Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential

21 January 2018

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Hypoxia-inducible factors modulate the stemness and malignancy of colon cancer cells by playing opposite roles in canonical Wnt signaling

21 January 2018

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Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

21 January 2018

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Differential effect of hypoxia on etoposide-induced DNA damage response and p53 regulation in different cell types

21 January 2018

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Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells.

21 January 2018

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The interplay of AMP-activated protein kinase and androgen receptor in prostate cancer cells

21 January 2018

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Reactive Oxygen Species in Cancer Stem Cells

21 January 2018

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Aerobic glycolysis: a novel target in kidney cancer

21 January 2018

1 reference

Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions

21 January 2018

1 reference

ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways

21 January 2018

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Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells

21 January 2018

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Rethinking the Regulation of Cellular Metabolism

21 January 2018

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Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cells

21 January 2018

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Intestinal Inflammation and Cancer

21 January 2018

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SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer

21 January 2018

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On the Origin of Cancer Cells

21 January 2018

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Targeting mitochondria as a therapeutic target in cancer

21 January 2018

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Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis

21 January 2018

1 reference

Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target

21 January 2018

1 reference

CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression

21 January 2018

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Effective elimination of cancer stem cells by a novel drug combination strategy

21 January 2018

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Single-cell metabolomics: analytical and biological perspectives

21 January 2018

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Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133 pancreatic cancer stem-like cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCP.25318

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release_5jjtcrv3n5gqxmpoaxof44s7uq

5 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5jjtcrv3n5gqxmpoaxof44s7uq

mapped directly with Wikidata item

24 November 2022

based on heuristic

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