Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. (Q38665092)

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5 March 2020

title

Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit (English)

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16

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Edmond Chan

17

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Shuji Ogino

23

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Suzanne Gaudet

25

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Kwok Kin Wong

29

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24

Nir Hacohen

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12

Pablo Tamayo

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30

William C Hahn

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31

David A Barbie

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9

Anna C Schinzel

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author name string

Zehua Zhu

1

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5 March 2020

Amir R Aref

2

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Travis J Cohoon

3

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Thanh U Barbie

4

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Yu Imamura

5

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Shenghong Yang

6

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Susan E Moody

7

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Rhine R Shen

8

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Tran C Thai

10

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Jacob B Reibel

11

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Jason T Godfrey

13

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Zhi Rong Qian

14

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Asher N Page

15

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Whitney Silkworth

18

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Mary T Labowsky

19

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Lior Rozhansky

20

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William E Gillanders

22

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Michael J Eck

26

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Jeffrey A Engelman

27

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Ryan B Corcoran

28

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Jill P Mesirov

21

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language of work or name

English

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publication date

20 January 2014

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5 March 2020

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volume

4

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issue

4

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5 March 2020

page(s)

452-465

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Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells

5 March 2020

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Structure and ubiquitination-dependent activation of TANK-binding kinase 1.

6 September 2017

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An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

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TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling

6 September 2017

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Screening therapeutic EMT blocking agents in a three-dimensional microenvironment

6 September 2017

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6 September 2017

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The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

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6 September 2017

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KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.

6 September 2017

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6 September 2017

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Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.

6 September 2017

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IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

6 September 2017

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TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation

6 September 2017

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

6 September 2017

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Emerging roles for the non-canonical IKKs in cancer

6 September 2017

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CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

6 September 2017

1 reference

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Targeting the cancer kinome through polypharmacology

6 September 2017

1 reference

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

6 September 2017

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Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma

6 September 2017

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Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation

6 September 2017

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6 September 2017

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6 September 2017

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Chemokine signaling via the CXCR2 receptor reinforces senescence

6 September 2017

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Identification of interleukin-1 and interleukin-6-responsive genes in human monocyte-derived macrophages using microarrays.

6 September 2017

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The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival

6 September 2017

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6 September 2017

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Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity

6 September 2017

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Targeting RAS signalling pathways in cancer therapy

6 September 2017

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Distinct requirements for Ras oncogenesis in human versus mouse cells

6 September 2017

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Resistance to methotrexate due to gene amplification in a patient with acute leukemia

6 September 2017

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STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

6 September 2017

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Novel cross-talk within the IKK family controls innate immunity

6 September 2017

1 reference

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A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

14 September 2017

1 reference

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Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.

14 September 2017

1 reference

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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

14 September 2017

1 reference

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Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

25 September 2017

1 reference

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IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer

25 September 2017

1 reference

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The differential effects of mutant p53 alleles on advanced murine lung cancer

31 August 2018

1 reference

12 December 2020

Species- and cell type-specific requirements for cellular transformation

1 reference

12 December 2020

Influence of TBK-1 on tumor angiogenesis and microvascular inflammation

1 reference

12 December 2020

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

1 reference

12 December 2020

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis

1 reference

12 December 2020

10.1158/2159-8290.CD-13-0646

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24444711 AND SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24444711 AND SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

24444711

1 reference