Tau in physiology and pathology (Q38657468)

5 September 2017

title

Tau in physiology and pathology (English)

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5 September 2017

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2

Eckhard Mandelkow

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5 September 2017

Yipeng Wang

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5 September 2017

language of work or name

English

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publication date

3 December 2015

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Nature Reviews Neuroscience

5 September 2017

published in

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5 September 2017

volume

17

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5 September 2017

issue

1

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5 September 2017

page(s)

5-21

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A protein factor essential for microtubule assembly

5 September 2017

cites work

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Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

31 March 2020

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Neurodegenerative tauopathies

31 March 2020

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

31 March 2020

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

31 March 2020

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Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target

31 March 2020

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Therapeutic strategies for tau mediated neurodegeneration

31 March 2020

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Spreading of pathology in neurodegenerative diseases: a focus on human studies

31 March 2020

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Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes

31 March 2020

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The primary structure and heterogeneity of tau protein from mouse brain

31 March 2020

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Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau).

31 March 2020

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Loss of fused in sarcoma (FUS) promotes pathological Tau splicing

31 March 2020

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MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy.

31 March 2020

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Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau

31 March 2020

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RNA protein granules modulate tau isoform expression and induce neuronal sprouting

31 March 2020

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Mitochondrial complex 1 inhibition increases 4-repeat isoform tau by SRSF2 upregulation.

31 March 2020

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RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

31 March 2020

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A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

31 March 2020

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Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

31 March 2020

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Profiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus

31 March 2020

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Tau isoform composition influences rate and extent of filament formation

31 March 2020

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Developmentally regulated expression of specific tau sequences

31 March 2020

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Isoforms changes of tau protein during development in various species

31 March 2020

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Tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for Alzheimer's disease.

31 March 2020

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Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

31 March 2020

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Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration

31 March 2020

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Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

31 March 2020

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

31 March 2020

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Structural polymorphism of 441-residue tau at single residue resolution

31 March 2020

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Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

31 March 2020

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Alternative conformations of the Tau repeat domain in complex with an engineered binding protein

31 March 2020

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Global hairpin folding of tau in solution

31 March 2020

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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

31 March 2020

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The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

31 March 2020

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Fetal-type phosphorylation of the tau in paired helical filaments

31 March 2020

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Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

31 March 2020

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Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

31 March 2020

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Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

31 March 2020

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Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics

31 March 2020

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Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates.

31 March 2020

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Phosphoprotein phosphatase activities in Alzheimer disease brain

31 March 2020

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I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A

31 March 2020

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Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.

31 March 2020

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Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease.

31 March 2020

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Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals.

31 March 2020

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Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.

31 March 2020

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The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

31 March 2020

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Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

31 March 2020

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Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

31 March 2020

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Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

31 March 2020

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Aβ Oligomers Cause Localized Ca2 Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

31 March 2020

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Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo.

31 March 2020

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The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

31 March 2020

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Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease

31 March 2020

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31 March 2020

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Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases

31 March 2020

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Acetylation of tau inhibits its degradation and contributes to tauopathy

31 March 2020

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Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

31 March 2020

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The microtubule-associated tau protein has intrinsic acetyltransferase activity

31 March 2020

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Acetylated tau neuropathology in sporadic and hereditary tauopathies

31 March 2020

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

31 March 2020

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Post-translational modifications of tau protein: implications for Alzheimer's disease.

31 March 2020

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Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease

31 March 2020

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Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5

31 March 2020

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O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

31 March 2020

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O-GlcNAc modification of tau directly inhibits its aggregation without perturbing the conformational properties of tau monomers

31 March 2020

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Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.

31 March 2020

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Molecular aging of tau: disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo

31 March 2020

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Tau protein from Alzheimer's disease patients is glycated at its tubulin-binding domain.

31 March 2020

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Selective tau tyrosine nitration in non-AD tauopathies

31 March 2020

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Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity.

31 March 2020

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CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

31 March 2020

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CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

31 March 2020

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Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation

31 March 2020

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Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

31 March 2020

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Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein

31 March 2020

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SUMO-1 marks the nuclear inclusions in familial neuronal intranuclear inclusion disease

31 March 2020

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SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

31 March 2020

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NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease

31 March 2020

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Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment

31 March 2020

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Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

31 March 2020

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Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes

31 March 2020

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Phosphorylation determines two distinct species of Tau in the central nervous system

31 March 2020

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Nuclear tau, a key player in neuronal DNA protection

31 March 2020

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Subcellular localization of tau mRNA in differentiating neuronal cell culture: implications for neuronal polarity.

31 March 2020

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Axonal tau mRNA localization coincides with tau protein in living neuronal cells and depends on axonal targeting signal.

31 March 2020

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Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway

31 March 2020

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Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons.

31 March 2020

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Tau in situ hybridization in normal and Alzheimer brain: localization in the somatodendritic compartment.

31 March 2020

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Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

31 March 2020

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Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death

31 March 2020

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Biochemistry and cell biology of tau protein in neurofibrillary degeneration

31 March 2020

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Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

31 March 2020

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Differential regulation of dynein and kinesin motor proteins by tau

31 March 2020

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Multiple-motor based transport and its regulation by Tau.

31 March 2020

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Swimming against the tide: mobility of the microtubule-associated protein tau in neurons

31 March 2020

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Molecular motors implicated in the axonal transport of tau and alpha-synuclein

31 March 2020

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Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases

31 March 2020

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Interaction of tau protein with the dynactin complex

31 March 2020

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Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice

31 March 2020

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Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

31 March 2020

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Overexpression of tau in a nonneuronal cell induces long cellular processes

31 March 2020

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Altered microtubule organization in small-calibre axons of mice lacking tau protein

31 March 2020

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Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation

31 March 2020

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Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers.

31 March 2020

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Identification of nuclear tau isoforms in human neuroblastoma cells

31 March 2020

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Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization

31 March 2020

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Huntington's disease is a four-repeat tauopathy with tau nuclear rods.

31 March 2020

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Tau reduction prevents disease in a mouse model of Dravet syndrome

31 March 2020

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Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.

31 March 2020

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Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice

31 March 2020

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Antisense reduction of tau in adult mice protects against seizures

31 March 2020

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Motor and cognitive deficits in aged tau knockout mice in two background strains.

31 March 2020

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Essential role of tau phosphorylation in adult hippocampal neurogenesis

31 March 2020

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Function of tau protein in adult newborn neurons

31 March 2020

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Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

31 March 2020

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Microtubule-associated protein tau is essential for long-term depression in the hippocampus

31 March 2020

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Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion

31 March 2020

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Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity

31 March 2020

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Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.

31 March 2020

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Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration

31 March 2020

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Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

31 March 2020

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Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

31 March 2020

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31 March 2020

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PART, a distinct tauopathy, different from classical sporadic Alzheimer disease

31 March 2020

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Are cases with tau pathology occurring in the absence of Aβ deposits part of the AD-related pathological process?

31 March 2020

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Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

31 March 2020

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Atomic structures of amyloid cross-beta spines reveal varied steric zippers

31 March 2020

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Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

31 March 2020

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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

31 March 2020

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Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

31 March 2020

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Zeta 14-3-3 protein favours the formation of human tau fibrillar polymers

31 March 2020

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Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy

31 March 2020

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A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

31 March 2020

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Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

31 March 2020

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Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

31 March 2020

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Oligomer formation of tau protein hyperphosphorylated in cells

31 March 2020

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Degradation of tau protein by autophagy and proteasomal pathways

31 March 2020

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Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo.

31 March 2020

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Caspase activation precedes and leads to tangles

31 March 2020

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Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

31 March 2020

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Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model

31 March 2020

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Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity

31 March 2020

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Transmission and spreading of tauopathy in transgenic mouse brain

31 March 2020

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Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

31 March 2020

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Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice

31 March 2020

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Distinct tau prion strains propagate in cells and mice and define different tauopathies

31 March 2020

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Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia

31 March 2020

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Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

31 March 2020

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Neurons may live for decades with neurofibrillary tangles

31 March 2020

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Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

31 March 2020

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In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons

31 March 2020

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Tau suppression in a neurodegenerative mouse model improves memory function

31 March 2020

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Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.

31 March 2020

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Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.

31 March 2020

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Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity

31 March 2020

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A beta oligomers - a decade of discovery

31 March 2020

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Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

31 March 2020

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Granular tau oligomers as intermediates of tau filaments

31 March 2020

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Trimeric tau is toxic to human neuronal cells at low nanomolar concentrations

31 March 2020

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Tau oligomers impair artificial membrane integrity and cellular viability

31 March 2020

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High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands

31 March 2020

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The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

31 March 2020

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The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy

31 March 2020

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Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone.

31 March 2020

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Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

31 March 2020

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Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

31 March 2020

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SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans

31 March 2020

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SUT-1 enables tau-induced neurotoxicity in C. elegans

31 March 2020

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Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

31 March 2020

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Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease.

31 March 2020

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

31 March 2020

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Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca( ) dysregulation

31 March 2020

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Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

31 March 2020

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Proteostasis and the aging proteome in health and disease

31 March 2020

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Physiological release of endogenous tau is stimulated by neuronal activity.

31 March 2020

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Neuronal activity regulates extracellular tau in vivo

31 March 2020

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The tau protein in human cerebrospinal fluid in Alzheimer's disease consists of proteolytically derived fragments

31 March 2020

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In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

31 March 2020

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Molecular anatomy of a trafficking organelle

31 March 2020

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Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies

31 March 2020

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Mechanisms of regulated unconventional protein secretion

31 March 2020

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Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

31 March 2020

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Characteristics and consequences of muscarinic receptor activation by tau protein.

31 March 2020

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Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles

31 March 2020

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Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology

31 March 2020

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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

31 March 2020

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Neuropathological stageing of Alzheimer-related changes

31 March 2020

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Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis

31 March 2020

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Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

31 March 2020

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Myelination of the nervous system: mechanisms and functions

31 March 2020

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Alzheimer's disease: cell-specific pathology isolates the hippocampal formation

31 March 2020

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Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau.

31 March 2020

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Tau aggregation inhibitor therapy: an exploratory phase 2 study in mild or moderate Alzheimer's disease

31 March 2020

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Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

31 March 2020

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A phase II trial of tideglusib in Alzheimer's disease

31 March 2020

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Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial.

31 March 2020

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Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial

31 March 2020

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Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

31 March 2020

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Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease

31 March 2020

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Hsp90-Tau complex reveals molecular basis for specificity in chaperone action

31 March 2020

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Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice

31 March 2020

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Autophagic degradation of tau in primary neurons and its enhancement by trehalose

31 March 2020

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Rapamycin alleviates toxicity of different aggregate-prone proteins

31 March 2020

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Tau immunotherapy and imaging.

31 March 2020

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Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

31 March 2020

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Open questions for Alzheimer's disease immunotherapy

31 March 2020

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Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance.

31 March 2020

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Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease

31 March 2020

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Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity

31 March 2020

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Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.

31 March 2020

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Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

31 March 2020

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MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

31 March 2020

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Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease.

31 March 2020

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Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease.

31 March 2020

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12 December 2020

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2.

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12 December 2020

Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.

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12 December 2020

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

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12 December 2020

Tau interacts with src-family non-receptor tyrosine kinases

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12 December 2020

Misregulation of tau alternative splicing in neurodegeneration and dementia

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12 December 2020

tau Regulation of microtubule-microtubule spacing and bundling

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12 December 2020

Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias

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12 December 2020

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization

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12 December 2020

Identifiers

DOI

10.1038/NRN.2015.1

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Dimensions Publication ID

5 September 2017

1021522996

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