Regulation of ceramide channel formation and disassembly: Insights on the initiation of apoptosis. (Q38639669)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26587005 AND SRC:MED&resulttype=core&format=json

1 March 2020

title

Regulation of ceramide channel formation and disassembly: Insights on the initiation of apoptosis (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26587005 AND SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26587005 AND SRC:MED&resulttype=core&format=json

1 March 2020

author name string

Majdouline Abou-Ghali

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26587005 AND SRC:MED&resulttype=core&format=json

1 March 2020

publication date

22 March 2015

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26587005 AND SRC:MED&resulttype=core&format=json

Saudi Journal of Biological Sciences

1 March 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26587005 AND SRC:MED&resulttype=core&format=json

1 March 2020

volume

22

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26587005 AND SRC:MED&resulttype=core&format=json

1 March 2020

issue

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26587005 AND SRC:MED&resulttype=core&format=json

1 March 2020

page(s)

760-772

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26587005 AND SRC:MED&resulttype=core&format=json

Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity.

1 March 2020

cites work

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Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling

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Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro

6 September 2017

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Mitochondrial outer membrane channels

6 September 2017

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6 September 2017

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Ceramide channels: Influence of molecular structure on channel formation in membranes

6 September 2017

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Ceramide synthases at the centre of sphingolipid metabolism and biology

6 September 2017

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Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes

6 September 2017

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Regulation of anti‐apoptotic BCL2‐proteins by non‐canonical interactions: The next step forward or two steps back?

6 September 2017

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Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation

6 September 2017

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Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events

6 September 2017

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Visualization of ceramide channels by transmission electron microscopy

6 September 2017

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Ceramide and the regulation of apoptosis and the stress response.

6 September 2017

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Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca2 Loading Capacity and Promotes Apoptosis

6 September 2017

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Ceramide synthases: roles in cell physiology and signaling

6 September 2017

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Activation of store-operated I(CRAC) by hydrogen peroxide.

6 September 2017

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The role of the ceramide acyl chain length in neurodegeneration: involvement of ceramide synthases

6 September 2017

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Cell stress and cell death

6 September 2017

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Cellular stress responses: cell survival and cell death

6 September 2017

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The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.

6 September 2017

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6 September 2017

The BCL-2 family reunion

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Ceramide channels and their role in mitochondria-mediated apoptosis

6 September 2017

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6 September 2017

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Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

6 September 2017

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6 September 2017

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The sphingolipid salvage pathway in ceramide metabolism and signaling

6 September 2017

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Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels

6 September 2017

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Sphingosine, a product of ceramide hydrolysis, influences the formation of ceramide channels.

6 September 2017

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Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations

6 September 2017

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A pharmacologic target of G3139 in melanoma cells may be the mitochondrial VDAC.

6 September 2017

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Dihydroceramide hinders ceramide channel formation: Implications on apoptosis

6 September 2017

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Searching for the molecular arrangement of transmembrane ceramide channels

6 September 2017

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Sphingosine forms channels in membranes that differ greatly from those formed by ceramide

6 September 2017

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Mitochondrial ceramide and the induction of apoptosis

6 September 2017

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Apoptotic pathways: ten minutes to dead

6 September 2017

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6 September 2017

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Internal dynamics and protein-matrix coupling in trehalose-coated proteins

6 September 2017

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

6 September 2017

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The pathophysiology of mitochondrial cell death

6 September 2017

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6 September 2017

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6 September 2017

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Cell death: critical control points

6 September 2017

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6 September 2017

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Enlargement and contracture of C2-ceramide channels

6 September 2017

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6 September 2017

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

6 September 2017

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6 September 2017

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6 September 2017

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Mitochondria and ceramide: intertwined roles in regulation of apoptosis

6 September 2017

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Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins

6 September 2017

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SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)

6 September 2017

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Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim the mitochondrion

6 September 2017

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A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast

6 September 2017

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Enzymes of sphingolipid metabolism: from modular to integrative signaling

6 September 2017

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The biochemistry of apoptosis

6 September 2017

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The mitochondrial permeability transition pore

6 September 2017

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Ceramide induces cytochrome c release from isolated mitochondria

6 September 2017

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Two distinct pathways leading to nuclear apoptosis

6 September 2017

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BAX-dependent transport of cytochrome c reconstituted in pure liposomes

6 September 2017

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Apoptotic DNA fragmentation

6 September 2017

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Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

6 September 2017

1 reference

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The mitochondrial permeability transition pore and its role in cell death

6 September 2017

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

6 September 2017

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Ca2 influx pathways mediated by swelling or stores depletion in mouse thymocytes

6 September 2017

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Programmed cell death in neurotumour cells involves the generation of ceramide

6 September 2017

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

6 September 2017

1 reference

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Ceramide inactivates cellular protein kinase Calpha

6 September 2017

1 reference

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Bcl-2 interrupts the ceramide-mediated pathway of cell death.

6 September 2017

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Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway.

6 September 2017

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

6 September 2017

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Trehalose in yeast, stress protectant rather than reserve carbohydrate

6 September 2017

1 reference

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The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.

6 September 2017

1 reference

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Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth

6 September 2017

1 reference

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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

6 September 2017

1 reference

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The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis

14 September 2017

1 reference

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Programmed cell death and the control of cell survival

14 September 2017

1 reference

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FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1.

14 September 2017

1 reference

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Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms

25 September 2017

1 reference

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Effects of alterations in calcium homeostasis on apoptosis during neoplastic progression.

25 September 2017

1 reference

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Ceramide: an intracellular mediator of apoptosis and growth suppression

25 September 2017

1 reference

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Programmed cell death and the control of cell survival: lessons from the nervous system

25 September 2017

1 reference

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Anchorage dependence, integrins, and apoptosis

25 September 2017

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Programmed cell death and Bcl-2 protection in the absence of a nucleus

25 September 2017

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Functions of ceramide in coordinating cellular responses to stress

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Recognition of apoptotic cells by phagocytes.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Ceramide: role in growth inhibitory cascades

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Role of ceramide in stimulation of the transcription of cytosolic phospholipase A2 and cyclooxygenase 2.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Mechanisms of programmed cell death and Bcl-2 protection

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Lipid raft composition modulates sphingomyelinase activity and ceramide-induced membrane physical alterations

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Modulation of total ceramide and constituent ceramide species in the acutely and chronically hypoxic mouse heart at different ages

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Modification of sodium channel gating by lanthanum. Some effects that cannot be explained by surface charge theory

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Very long chain ceramides interfere with C16-ceramide-induced channel formation: A plausible mechanism for regulating the initiation of intrinsic apoptosis.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Dynamics of ceramide channels detected using a microfluidic system

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Bax and Bcl-xL exert their regulation on different sites of the ceramide channel.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

N-Myristoylation targets dihydroceramide Delta4-desaturase 1 to mitochondria: partial involvement in the apoptotic effect of myristic acid.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Pore formation in and enlargement of phospholipid liposomes by synthetic models of ceramides and sphingomyelin

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Ceramide induces release of pro-apoptotic proteins from mitochondria by either a Ca2 -dependent or a Ca2 -independent mechanism

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Lack of Apaf-1 expression confers resistance to cytochrome c-driven apoptosis in cardiomyocytes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Ceramide increases Fas-mediated apoptosis in glioblastoma cells through FLIP down-regulation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

C(2)-ceramide-induced circular smooth muscle cell contraction involves PKC-epsilon and p44/p42 MAPK activation in cat oesophagus. Mitogen-activated protein kinase

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Membrane restructuring via ceramide results in enhanced solute efflux

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

La(3 ) stabilizes the hexagonal II (H(II)) phase in phosphatidylethanolamine membranes.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

A mechanosensitive ion channel in the yeast plasma membrane

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4625378

3 December 2018

DNA damage and apoptosis

1 reference

12 December 2020

Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells

1 reference

12 December 2020

Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis

1 reference

12 December 2020

Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore

1 reference

12 December 2020

Programmed cell death induced by ceramide

1 reference

12 December 2020

Interactions of La3 with phosphatidylserine vesicles. Binding, phase transition, leakage and fusion

1 reference

12 December 2020

Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking

1 reference

12 December 2020

Single-channel characterization of a nonselective cation channel from human placental microvillus membranes. Large conductance, multiplicity of conductance states, and inhibition by lanthanides

1 reference

12 December 2020

Ceramide Induces CytochromecRelease from Isolated Mitochondria

1 reference

12 December 2020

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1 reference

12 December 2020

Effect of ceramide structure on membrane biophysical properties: The role of acyl chain length and unsaturation

1 reference

12 December 2020

Regulation of cell movement is mediated by stretch-activated calcium channels

1 reference

12 December 2020

Early transitory rise in intracellular pH leads to Bax conformation change during ceramide-induced apoptosis

1 reference

12 December 2020

Calcium release-activated calcium current in rat mast cells

1 reference

12 December 2020

10.1016/J.SJBS.2015.03.005

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26587005 AND SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26587005 AND SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

26587005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26587005 AND SRC:MED&resulttype=core&format=json