The Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Cardiovascular Homeostasis: A Non-Systematic Literature Review. (Q38637552)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28782494 AND SRC:MED&resulttype=core&format=json

26 March 2020

review article

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title

The Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Cardiovascular Homeostasis: A Non-Systematic Literature Review (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28782494 AND SRC:MED&resulttype=core&format=json

regulation of gene expression

26 March 2020

main subject

cardiovascular disease

3 references

17 June 2019

8 September 2019

28 September 2019

1 reference

8 September 2019

1 reference

28 September 2019

1

1 reference

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26 March 2020

Essa Hariri

2

1 reference

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26 March 2020

6

Francine Welty

1 reference

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26 March 2020

author name string

Perla Saoud

3

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26 March 2020

Christelle Lteif

4

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26 March 2020

Louis Lteif

5

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26 March 2020

publication date

1 January 2017

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Current cardiology reviews

26 March 2020

published in

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26 March 2020

volume

13

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26 March 2020

issue

4

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26 March 2020

page(s)

274-282

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Creative Commons Attribution-NonCommercial

26 March 2020

copyright license

3 references

17 June 2019

8 September 2019

28 September 2019

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730960

Role of lipoproteins and proprotein convertase subtilisin/kexin type 9 in endotoxin clearance in sepsis

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1 reference

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1 reference

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1 reference

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Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis.

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1 reference

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1 reference

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Suppressor of Cytokine Signaling-3 (SOCS-3) Induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Expression in Hepatic HepG2 Cell Line.

16 September 2018

1 reference

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PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies

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PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension.

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Association of plasma PCSK9 levels with white blood cell count and its subsets in patients with stable coronary artery disease

16 September 2018

1 reference

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Risk prediction with proprotein convertase subtilisin/kexin type 9 (PCSK9) in patients with stable coronary disease on statin treatment

16 September 2018

1 reference

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Chronic kidney disease on hemodialysis is associated with decreased serum PCSK9 levels

16 September 2018

1 reference

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Proteinuria and its relation to cardiovascular disease

16 September 2018

1 reference

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Plasma PCSK9 in nephrotic syndrome and in peritoneal dialysis: a cross-sectional study.

16 September 2018

1 reference

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The role of oxidized low-density lipoproteins in atherosclerosis: the myths and the facts.

16 September 2018

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Short-term impact of low-dose atorvastatin on serum proprotein convertase subtilisin/kexin type 9.

16 September 2018

1 reference

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16 September 2018

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Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver

16 September 2018

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730960

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16 September 2018

1 reference

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16 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730960

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice

16 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730960

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

16 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730960

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

16 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730960

Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification

16 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730960

Seven lessons from two candidate genes in human essential hypertension: angiotensinogen and epithelial sodium channel

16 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730960

The puzzle of hypertension in African-Americans.

16 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730960

Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice

16 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730960

Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes melli

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730960

Relation of circulating PCSK9 concentration to fibrinogen in patients with stable coronary artery disease

3 December 2018

1 reference

12 December 2020

Atherosclerosis and CAD

1 reference

12 December 2020

US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008

1 reference

12 December 2020

Insulin-secreting beta-cell dysfunction induced by human lipoproteins

1 reference

12 December 2020

Plasma proprotein convertase subtilisin-kexin type 9 does not change during 24h insulin infusion in healthy subjects and type 2 diabetic patients

1 reference

12 December 2020

10.2174/1573403X13666170804150954

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28782494 AND SRC:MED&resulttype=core&format=json

26 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28782494 AND SRC:MED&resulttype=core&format=json

26 March 2020

PubMed publication ID

28782494

1 reference