Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows. (Q38624559)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28809006 AND SRC:MED&resulttype=core&format=json

27 March 2020

title

Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28809006 AND SRC:MED&resulttype=core&format=json

27 March 2020

1 reference

protein-protein interaction

1 reference

1 reference

Alexander Goncearenco

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28809006 AND SRC:MED&resulttype=core&format=json

27 March 2020

5

Anna R Panchenko

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28809006 AND SRC:MED&resulttype=core&format=json

27 March 2020

author name string

Minghui Li

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28809006 AND SRC:MED&resulttype=core&format=json

27 March 2020

Franco L Simonetti

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28809006 AND SRC:MED&resulttype=core&format=json

27 March 2020

Benjamin A Shoemaker

4

1 reference

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27 March 2020

language of work or name

English

0 references

publication date

1 January 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28809006 AND SRC:MED&resulttype=core&format=json

Methods in Molecular Biology

27 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28809006 AND SRC:MED&resulttype=core&format=json

27 March 2020

volume

1647

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28809006 AND SRC:MED&resulttype=core&format=json

27 March 2020

page(s)

221-236

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28809006 AND SRC:MED&resulttype=core&format=json

Annotating Mutational Effects on Proteins and Protein Interactions: Designing Novel and Revisiting Existing Protocols

27 March 2020

cites work

1 reference

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PubChem BioAssay: 2017 update

23 June 2018

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Chemical Variations on the p53 Reactivation Theme

23 June 2018

1 reference

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MutaBind estimates and interprets the effects of sequence variants on protein-protein interactions

23 June 2018

1 reference

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SAAMBE: Webserver to Predict the Charge of Binding Free Energy Caused by Amino Acids Mutations

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions.

23 June 2018

1 reference

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How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures.

23 June 2018

1 reference

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BindingDB in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacology

23 June 2018

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PubChem Substance and Compound databases

23 June 2018

1 reference

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Connecting proteins with drug-like compounds: Open source drug discovery workflows with BindingDB and KNIME.

23 June 2018

1 reference

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Structural Perspectives on the Evolutionary Expansion of Unique Protein-Protein Binding Sites.

23 June 2018

1 reference

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A proteome-scale map of the human interactome network

23 June 2018

1 reference

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CDD: NCBI's conserved domain database

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

23 June 2018

1 reference

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Resistance acquisition to MDM2 inhibitors.

23 June 2018

1 reference

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Coverage of protein domain families with structural protein-protein interactions: current progress and future trends.

23 June 2018

1 reference

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Structural bioinformatics of the interactome.

23 June 2018

1 reference

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Predicting the Impact of Missense Mutations on Protein-Protein Binding Affinity.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

KNIME-CDK: Workflow-driven cheminformatics

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

The effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on protein-protein interactions.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

The Taverna workflow suite: designing and executing workflows of Web Services on the desktop, web or in the cloud

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Drug discovery applications for KNIME: an open source data mining platform

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Large-scale mapping of human protein interactome using structural complexes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Modulating protein-protein interactions with small molecules: the importance of binding hotspots

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

New developments on the cheminformatics open workflow environment CDK-Taverna

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

IBIS (Inferred Biomolecular Interaction Server) reports, predicts and integrates multiple types of conserved interactions for proteins

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

HotRegion: a database of predicted hot spot clusters

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Selective inhibition of BET bromodomains

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

myExperiment: a repository and social network for the sharing of bioinformatics workflows

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

BioCatalogue: a universal catalogue of web services for the life sciences

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

The overlap of small molecule and protein binding sites within families of protein structures

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Inferred Biomolecular Interaction Server--a web server to analyze and predict protein interacting partners and binding sites

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Modeling effects of human single nucleotide polymorphisms on protein-protein interactions

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Finding biologically relevant protein domain interactions: conserved binding mode analysis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Conservation and relative importance of residues across protein-protein interfaces

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Protein-protein interactions: structurally conserved residues distinguish between binding sites and exposed protein surfaces

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Anatomy of hot spots in protein interfaces

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Developing science gateways for drug discovery in a grid environment

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Interactome3D: adding structural details to protein networks

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Extending foldamer design beyond α-helix mimicry: α/β-peptide inhibitors of vascular endothelial growth factor signaling.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

Protein-protein interfaces: analysis of amino acid conservation in homodimers

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5880202

The Relationship Between Sequence and Interaction Divergence in Proteins

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007/978-1-4939-7201-2_15

Ten thousand interactions for the molecular biologist

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007/978-1-4939-7201-2_15

10.1007/978-1-4939-7201-2_15

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28809006 AND SRC:MED&resulttype=core&format=json

release_3fcyil734rhxhciowsvisalkbi

27 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/3fcyil734rhxhciowsvisalkbi

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28809006 AND SRC:MED&resulttype=core&format=json

27 March 2020

PubMed publication ID

28809006

1 reference