New Perspectives for the Rescue of Cognitive Disability in Down Syndrome (Q38607518)

26468184

4 September 2017

title

New Perspectives for the Rescue of Cognitive Disability in Down Syndrome (English)

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4 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6608177&resulttype=core&format=json

15 May 2020

Renata Bartesaghi

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15 May 2020

Jean M Delabar

3

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15 May 2020

Mara Dierssen Sotos

4

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15 May 2020

Diana W. Bianchi

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15 May 2020

author name string

Carmen Martínez-Cué

5

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15 May 2020

language of work or name

English

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publication date

1 October 2015

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26468184

4 September 2017

published in

Journal of Neuroscience

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15 May 2020

volume

35

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15 May 2020

issue

41

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15 May 2020

page(s)

13843-13852

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Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse

15 May 2020

cites work

1 reference

12 December 2020

Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome

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Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice

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Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse.

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Behavioral phenotype of individuals with Down syndrome

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Distinct cortical migrations from the medial and lateral ganglionic eminences.

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Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease

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Serotonin and brain development: role in human developmental diseases

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Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure

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Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

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Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome

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The chromosome 21 transcription factor ETS2 transactivates the beta-APP promoter: implications for Down syndrome

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12 December 2020

App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

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Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi study

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A voxel-based morphometric study of nondemented adults with Down Syndrome

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Model of autism: increased ratio of excitation/inhibition in key neural systems

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GABA and Schizophrenia: A Review of Basic Science and Clinical Studies

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Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.

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Neurobiology of Tourette's syndrome: concepts of neuroanatomic localization and neurochemical abnormalities

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Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.

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12 December 2020

Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen

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Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome

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12 December 2020

Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

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12 December 2020

Minocycline prevents cholinergic loss in a mouse model of Down's syndrome

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Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.

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Computerized training of working memory in children with ADHD--a randomized, controlled trial.

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ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons.

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12 December 2020

Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12.

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12 December 2020

Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice

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12 December 2020

Fluoxetine (Prozac) interaction with the mitochondrial voltage-dependent anion channel and protection against apoptotic cell death

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12 December 2020

Biometry of face and brain in fetuses with trisomy 21

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12 December 2020

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice

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12 December 2020

Dendritic pathology in mental retardation: from molecular genetics to neurobiology.

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12 December 2020

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

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12 December 2020

Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome.

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12 December 2020

Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome

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12 December 2020

Beta-amyloid, oxidative stress and down syndrome

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12 December 2020

The Connectivity Map: a new tool for biomedical research

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12 December 2020

Familial 4.3 Mb duplication of 21q22 sheds new light on the Down syndrome critical region

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12 December 2020

(-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons.

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12 December 2020

Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

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12 December 2020

Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice

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12 December 2020

Changes in cortical activity after training of working memory--a single-subject analysis.

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12 December 2020

Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships

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12 December 2020

Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

1 reference

12 December 2020

DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease

1 reference

12 December 2020

Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome

1 reference

12 December 2020

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease

1 reference

12 December 2020

Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome.

1 reference

12 December 2020

Development of the human cerebral cortex: Boulder Committee revisited

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12 December 2020

Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

1 reference

12 December 2020

Fetal human brain exhibits a prenatal peak in the density of serotonin 5-HT1A receptors

1 reference

12 December 2020

Reduced cell number in the neocortical part of the human fetal brain in Down syndrome

1 reference

12 December 2020

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome

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12 December 2020

Prevention of developmental delays in a Down syndrome mouse model

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12 December 2020

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

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12 December 2020

Exercising your brain: a review of human brain plasticity and training-induced learning

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12 December 2020

SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake

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12 December 2020

Changes in cortical dopamine D1 receptor binding associated with cognitive training.

1 reference

12 December 2020

Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

1 reference

12 December 2020

The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome

1 reference

12 December 2020

The impact of flavonoids on memory: physiological and molecular considerations

1 reference

12 December 2020

Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses

1 reference

12 December 2020

Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome

1 reference

12 December 2020

Dyrk1A binds to multiple endocytic proteins required for formation of clathrin-coated vesicles

1 reference

12 December 2020

Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome.

1 reference

12 December 2020

Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down's syndrome.

1 reference

12 December 2020

Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

1 reference

12 December 2020

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

1 reference

12 December 2020

Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome.

1 reference

12 December 2020

Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome

1 reference

12 December 2020

Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model

1 reference

12 December 2020

Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome

1 reference

12 December 2020

Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

1 reference

12 December 2020

Postural control in children, teenagers and adults with Down syndrome

1 reference

12 December 2020

Distinctive Phenotypic Abnormalities Associated with Submicroscopic 21q22 Deletion Including DYRK1A.

1 reference

12 December 2020

Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome.

1 reference

12 December 2020

Nutraceutical antioxidants as novel neuroprotective agents

1 reference

12 December 2020

The role of DYRK1A in neurodegenerative diseases

1 reference

12 December 2020

Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly.

1 reference

12 December 2020

α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome

1 reference

12 December 2020

Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months

1 reference

12 December 2020

Neural correlates of training-related working-memory gains in old age.

1 reference

12 December 2020

Is it possible to improve neurodevelopmental abnormalities in Down syndrome?

1 reference

12 December 2020

Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

1 reference

12 December 2020

Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome

1 reference

12 December 2020

The amniotic fluid transcriptome: a source of novel information about human fetal development

1 reference

12 December 2020

Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future

1 reference

12 December 2020

Neurological phenotypes for Down syndrome across the life span

1 reference

12 December 2020

Green tea epigallocatechin-3-gallate (EGCG) promotes neural progenitor cell proliferation and sonic hedgehog pathway activation during adult hippocampal neurogenesis

1 reference

12 December 2020

The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain.

1 reference

12 December 2020

Novel neurodevelopmental information revealed in amniotic fluid supernatant transcripts from fetuses with trisomies 18 and 21.

1 reference

12 December 2020

Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists.

1 reference

12 December 2020

Early pharmacotherapy with fluoxetine rescues dendritic pathology in the Ts65Dn mouse model of down syndrome

1 reference

12 December 2020

Activity-dependent phosphorylation of dynamin 1 at serine 857.

1 reference

12 December 2020

DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis

1 reference

12 December 2020

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke

1 reference

12 December 2020

Down syndrome: the brain in trisomic mode

1 reference

12 December 2020

Prenatal treatment prevents learning deficit in Down syndrome model

1 reference

12 December 2020

Effects of 10 Hz and 20 Hz transcranial alternating current stimulation (tACS) on motor functions and motor cortical excitability

1 reference

12 December 2020

Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome

1 reference

12 December 2020

Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.

1 reference

12 December 2020

Re-opening Windows: Manipulating Critical Periods for Brain Development

1 reference

12 December 2020

Action video games make dyslexic children read better

1 reference

12 December 2020

CNS-targeted production of IL-17A induces glial activation, microvascular pathology and enhances the neuroinflammatory response to systemic endotoxemia

1 reference

12 December 2020

Short-term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro-cognitive benefit in a mouse model of Down's syndrome

1 reference

12 December 2020

Multiplex genetic fate mapping reveals a novel route of neocortical neurogenesis, which is altered in the Ts65Dn mouse model of Down syndrome

1 reference

12 December 2020

Noninvasive prenatal testing creates an opportunity for antenatal treatment of Down syndrome

1 reference

12 December 2020

Pharmacotherapy with fluoxetine restores functional connectivity from the dentate gyrus to field CA3 in the Ts65Dn mouse model of down syndrome

1 reference

12 December 2020

Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome

1 reference

12 December 2020

Whole-brain voxel-based morphometry study of children and adolescents with Down syndrome

1 reference

12 December 2020

Computerized memory training leads to sustained improvement in visuospatial short-term memory skills in children with Down syndrome

1 reference

12 December 2020

The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome

1 reference

12 December 2020

Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis

1 reference

12 December 2020

Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A.

1 reference

12 December 2020

Polymorphisms in the dopamine receptor 2 gene region influence improvements during working memory training in children and adolescents

1 reference

12 December 2020

Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model

1 reference

12 December 2020

Video game training enhances cognitive control in older adults

1 reference

12 December 2020

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

1 reference

12 December 2020

Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of Down syndrome

1 reference

12 December 2020

Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome

1 reference

12 December 2020

Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model.

1 reference

12 December 2020

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

1 reference

12 December 2020

Frontal white matter integrity in adults with Down syndrome with and without dementia

1 reference

12 December 2020

Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice

1 reference

12 December 2020

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

1 reference

12 December 2020

DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease

1 reference

12 December 2020

Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice

1 reference

12 December 2020

Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome

1 reference

12 December 2020

Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice

1 reference

12 December 2020

Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations

1 reference

12 December 2020

The amniotic fluid transcriptome as a guide to understanding fetal disease

1 reference

12 December 2020

The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome.

1 reference

12 December 2020

Pregnancy: Prepare for unexpected prenatal test results

1 reference

12 December 2020

DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

1 reference

12 December 2020

Allopregnanolone increases mature excitatory synapses along dendrites via protein kinase A signaling.

1 reference

12 December 2020

A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine

1 reference

12 December 2020

Spine distribution along the apical dendrites of the pyramidal neurons in Down's syndrome. A quantitative Golgi study.

1 reference

12 December 2020

Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative Golgi study

1 reference

12 December 2020

A mouse model for Down syndrome exhibits learning and behaviour deficits

1 reference

12 December 2020

minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila

1 reference

12 December 2020

Molecular mapping of twenty-four features of Down syndrome on chromosome 21.

1 reference

12 December 2020

A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.

1 reference

12 December 2020

Consequences of trisomy 16 for mouse brain development: corticogenesis in a model of Down syndrome.

1 reference

12 December 2020

Early clinical and EEG features of infantile spasms in Down syndrome

1 reference

12 December 2020

Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome

1 reference

12 December 2020

Assessment of the Quality of Sitting and Gait Patterns in Children with Down’s Syndrome

1 reference

12 December 2020

Altered long-term potentiation in the young and old Ts65Dn mouse, a model for down syndrome

1 reference

12 December 2020

Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues

1 reference

12 December 2020

10.1523/JNEUROSCI.2775-15.2015

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6608177&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6608177&resulttype=core&format=json

15 May 2020

26468184

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