Exploring the emerging complexity in transcriptional regulation of energy homeostasis (Q38605684)

4 September 2017

title

Exploring the emerging complexity in transcriptional regulation of energy homeostasis (English)

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4 September 2017

3

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4 September 2017

Adelheid Lempradl

1

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4 September 2017

J Andrew Pospisilik

series ordinal

2

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4 September 2017

publication date

13 October 2015

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4 September 2017

published in

Nature Reviews Genetics

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4 September 2017

volume

16

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4 September 2017

issue

11

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4 September 2017

page(s)

665-681

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Signal Transduction and the Control of Gene Expression

4 September 2017

cites work

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Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism.

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The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

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CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

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CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis

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Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic beta cell

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Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis

21 January 2018

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Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

21 January 2018

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Role of Signal Transducer and Activator of Transcription 3 in Regulation of Hypothalamic Proopiomelanocortin Gene Expression by Leptin

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Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

21 January 2018

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Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis

21 January 2018

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Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding

21 January 2018

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Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity

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The role of JAK-STAT signaling in adipose tissue function

21 January 2018

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Glucose sensing by ChREBP/MondoA-Mlx transcription factors.

21 January 2018

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Novel insights into ChREBP regulation and function.

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

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mTOR signaling in cellular and organismal energetics

21 January 2018

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Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

21 January 2018

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Activation of PPARgamma coactivator-1 through transcription factor docking

21 January 2018

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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

21 January 2018

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Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha

21 January 2018

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Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity

21 January 2018

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RIP140, a Janus metabolic switch involved in defense functions

21 January 2018

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Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver

21 January 2018

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A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism

21 January 2018

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Steroid receptor coactivator-1 is a histone acetyltransferase

21 January 2018

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Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300

21 January 2018

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Nuclear receptor coactivators: master regulators of human health and disease

21 January 2018

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Translating the Histone Code

21 January 2018

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The presence of acetyl groups of histones

21 January 2018

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Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription

21 January 2018

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ATP-citrate lyase links cellular metabolism to histone acetylation

21 January 2018

1 reference

A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation

21 January 2018

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Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

21 January 2018

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Sir2: an NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging

21 January 2018

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Minireview: NAD , a circadian metabolite with an epigenetic twist

21 January 2018

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Circadian control of the NAD salvage pathway by CLOCK-SIRT1

21 January 2018

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Epigenetic control of rDNA loci in response to intracellular energy status

21 January 2018

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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

21 January 2018

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The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

21 January 2018

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Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins

21 January 2018

1 reference

Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor

21 January 2018

1 reference

The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation

21 January 2018

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Influence of threonine metabolism on S-adenosylmethionine and histone methylation

21 January 2018

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Nutritional control of epigenetic processes in yeast and human cells

21 January 2018

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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

21 January 2018

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Histone demethylation by a family of JmjC domain-containing proteins

21 January 2018

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Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process

21 January 2018

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FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure

21 January 2018

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Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells

21 January 2018

1 reference

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

21 January 2018

1 reference

Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code

21 January 2018

1 reference

Modification of histones by sugar β-N-acetylglucosamine (GlcNAc) occurs on multiple residues, including histone H3 serine 10, and is cell cycle-regulated

21 January 2018

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AMPK regulates histone H2B O-GlcNAcylation

21 January 2018

1 reference

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation

21 January 2018

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Histone phosphorylation: a chromatin modification involved in diverse nuclear events

21 January 2018

1 reference

Nuclear protein modification and chromatin substructure. 3. Relationship between poly(adenosine diphosphate) ribosylation and different functional forms of chromatin

21 January 2018

1 reference

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

21 January 2018

1 reference

ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation

21 January 2018

1 reference

Poly(ADP-ribose)polymerase-1 (PARP1) controls adipogenic gene expression and adipocyte function

21 January 2018

1 reference

Lysine succinylation and lysine malonylation in histones.

21 January 2018

1 reference

Lysine propionylation and butyrylation are novel post-translational modifications in histones

21 January 2018

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Histone h3 glutathionylation in proliferating mammalian cells destabilizes nucleosomal structure

21 January 2018

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Macro domains as metabolite sensors on chromatin.

21 January 2018

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Histone variant macroH2A1 deletion in mice causes female-specific steatosis

21 January 2018

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Developmental changes in histone macroH2A1-mediated gene regulation

21 January 2018

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Mice without macroH2A histone variants

21 January 2018

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Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster

21 January 2018

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

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Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes

21 January 2018

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Weight loss after gastric bypass surgery in human obesity remodels promoter methylation

21 January 2018

1 reference

Control of nuclear receptor activities in metabolism by post-translational modifications

21 January 2018

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Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 January 2018

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Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

21 January 2018

1 reference

O-GlcNAc regulates FoxO activation in response to glucose

21 January 2018

1 reference

Starvation-induced transgenerational inheritance of small RNAs in C. elegans.

21 January 2018

1 reference

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

21 January 2018

1 reference

In utero effects. In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

21 January 2018

1 reference

Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development

21 January 2018

1 reference

Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals

21 January 2018

1 reference

Paternal diet defines offspring chromatin state and intergenerational obesity

21 January 2018

1 reference

Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data

21 January 2018

1 reference

Chromatin structure, epigenetic mechanisms and long-range interactions in the human insulin locus.

21 January 2018

1 reference

Latent enhancers activated by stimulation in differentiated cells

21 January 2018

1 reference

RNA-mediated epigenetic regulation of gene expression

21 January 2018

1 reference

A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element

21 January 2018

1 reference

The emerging role of microRNAs and nutrition in modulating health and disease

21 January 2018

1 reference

A major epigenetic programming mechanism guided by piRNAs

21 January 2018

1 reference

Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state

21 January 2018

1 reference

Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila

21 January 2018

1 reference

MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline

21 January 2018

1 reference

AGO3 Slicer activity regulates mitochondria-nuage localization of Armitage and piRNA amplification

21 January 2018

1 reference

Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome.

21 January 2018

1 reference

Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes

21 January 2018

1 reference

Long noncoding RNAs regulate adipogenesis

21 January 2018

1 reference

Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity.

21 January 2018

1 reference

Regulation of hepatic lipogenesis by the transcription factor XBP1

21 January 2018

1 reference

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

21 January 2018

1 reference

How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy

21 January 2018

1 reference

An integrated encyclopedia of DNA elements in the human genome

21 January 2018

1 reference

Control of pancreas and liver gene expression by HNF transcription factors

21 January 2018

1 reference

PPARγ signaling and metabolism: the good, the bad and the future

21 January 2018

1 reference

Tissue-specific actions of FXR in metabolism and cancer

21 January 2018

1 reference

Liver X receptors in lipid metabolism: opportunities for drug discovery

21 January 2018

1 reference

Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases

21 January 2018

1 reference

Regulation of the SREBP transcription factors by mTORC1.

21 January 2018

1 reference

Stat3 regulates genes common to both wound healing and cancer

21 January 2018

1 reference

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

21 January 2018

1 reference

Genetic studies of body mass index yield new insights for obesity biology

21 January 2018

1 reference

Glucose tolerance at age 58 and the decline of glucose tolerance in comparison with age 50 in people prenatally exposed to the Dutch famine.

21 January 2018

1 reference

Obesity in young men after famine exposure in utero and early infancy

21 January 2018

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Coronary heart disease after prenatal exposure to the Dutch famine, 1944-45

21 January 2018

1 reference

I'm eating for two: parental dietary effects on offspring metabolism

21 January 2018

1 reference

Transgenerational epigenetic inheritance: myths and mechanisms

21 January 2018

1 reference

Transcriptional control of metabolic and inflammatory pathways by nuclear receptor SUMOylation

21 January 2018

1 reference

The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation.

21 January 2018

1 reference

Identification of Posttranslational Modifications in Peroxisome Proliferator-Activated Receptor γ Using Mass Spectrometry.

21 January 2018

1 reference

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ

21 January 2018

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O-GlcNAc modification of PPARγ reduces its transcriptional activity

21 January 2018

1 reference

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4α regulates expression of genes required for glucose transport and metabolism

21 January 2018

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21 January 2018

1 reference

Dynamic glycosylation of the transcription factor CREB: a potential role in gene regulation

21 January 2018

1 reference

FOXOs: signalling integrators for homeostasis maintenance

21 January 2018

1 reference

The Foxa family of transcription factors in development and metabolism

21 January 2018

1 reference

Stable chromatin binding prevents FoxA acetylation, preserving FoxA chromatin remodeling

21 January 2018

1 reference

Nuclear mobility and activity of FOXA1 with androgen receptor are regulated by SUMOylation

21 January 2018

1 reference

Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation

21 January 2018

1 reference

Toward a new STATe: the role of STATs in mitochondrial function

21 January 2018

1 reference

The JAK-STAT Pathway at Twenty

21 January 2018

1 reference

Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP.

21 January 2018

1 reference

Expanding roles for SREBP in metabolism

21 January 2018

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The Akt-SREBP nexus: cell signaling meets lipid metabolism.

21 January 2018

1 reference

Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway

21 January 2018

1 reference

The nexus of chromatin regulation and intermediary metabolism.

21 January 2018

1 reference

Metabolic regulation of epigenetics

21 January 2018

1 reference

A histone mutant reproduces the phenotype caused by loss of histone-modifying factor Polycomb.

21 January 2018

1 reference

Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer

21 January 2018

1 reference

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

21 January 2018

1 reference

Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice

31 March 2020

1 reference

Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation

31 March 2020

1 reference

Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.

31 March 2020

1 reference

Foxa2, a novel transcriptional regulator of insulin sensitivity

31 March 2020

1 reference

Multiple post-translational modifications in hepatocyte nuclear factor 4α

31 March 2020

1 reference

Acetylation of cAMP-responsive element-binding protein (CREB) by CREB-binding protein enhances CREB-dependent transcription

31 March 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/26460345

31 March 2020

1 reference

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structural modifications of histones and their possible role in the regulation of ribonucleic acid synthesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26460345

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

O-GlcNAcylation Links ChREBP and FXR to Glucose-Sensing

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26460345

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG3941

1 reference

Dimensions Publication ID

4 September 2017

1008077621

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1 reference