Regulation of innate immune cell function by mTOR. (Q38592317)

26403194

4 September 2017

title

Regulation of innate immune cell function by mTOR. (English)

1 reference

4 September 2017

0 references

1

1 reference

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3 June 2020

author name string

Markus Hengstschläger

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26403194 AND SRC:MED&resulttype=core&format=json

3 June 2020

Monika Linke

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26403194 AND SRC:MED&resulttype=core&format=json

3 June 2020

publication date

1 September 2015

1 reference

26403194

Nature Reviews Immunology

4 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26403194 AND SRC:MED&resulttype=core&format=json

3 June 2020

volume

15

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26403194 AND SRC:MED&resulttype=core&format=json

3 June 2020

issue

10

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26403194 AND SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

599-614

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mTOR signaling in growth control and disease

3 June 2020

cites work

1 reference

Making new contacts: the mTOR network in metabolism and signalling crosstalk

21 January 2018

1 reference

A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation

21 January 2018

1 reference

Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling

21 January 2018

1 reference

Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase

21 January 2018

1 reference

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

21 January 2018

1 reference

The TSC-mTOR signaling pathway regulates the innate inflammatory response

21 January 2018

1 reference

Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells.

21 January 2018

1 reference

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells

21 January 2018

1 reference

mTOR and GSK-3 shape the CD4 T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS.

21 January 2018

1 reference

mTOR kinase inhibitor AZD8055 enhances the immunotherapeutic activity of an agonist CD40 antibody in cancer treatment

21 January 2018

1 reference

Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury.

21 January 2018

1 reference

TSC1 controls macrophage polarization to prevent inflammatory disease.

21 January 2018

1 reference

The TSC-mTOR pathway regulates macrophage polarization

21 January 2018

1 reference

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

21 January 2018

1 reference

Regulation of translation is required for dendritic cell function and survival during activation

21 January 2018

1 reference

Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR.

21 January 2018

1 reference

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

21 January 2018

1 reference

The translational landscape of mTOR signalling steers cancer initiation and metastasis

21 January 2018

1 reference

Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens

21 January 2018

1 reference

Integrating canonical and metabolic signalling programmes in the regulation of T cell responses

21 January 2018

1 reference

Metabolism of inflammation limited by AMPK and pseudo-starvation

21 January 2018

1 reference

mTORC2 in the center of cancer metabolic reprogramming

21 January 2018

1 reference

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

21 January 2018

1 reference

mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc

21 January 2018

1 reference

Amino acid signalling upstream of mTOR

21 January 2018

1 reference

A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.

21 January 2018

1 reference

Rab1A is an mTORC1 activator and a colorectal oncogene

21 January 2018

1 reference

Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition

21 January 2018

1 reference

Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1α to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease

21 January 2018

1 reference

Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR)

21 January 2018

1 reference

Regulation of mTORC1 and its impact on gene expression at a glance

21 January 2018

1 reference

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

21 January 2018

1 reference

Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells.

21 January 2018

1 reference

The role of tuberous sclerosis complex 1 in regulating innate immunity

21 January 2018

1 reference

Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice.

21 January 2018

1 reference

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

21 January 2018

1 reference

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.

21 January 2018

1 reference

Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function.

21 January 2018

1 reference

Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation

21 January 2018

1 reference

Interdependence of hypoxic and innate immune responses

21 January 2018

1 reference

Innate immune memory: towards a better understanding of host defense mechanisms

21 January 2018

1 reference

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

21 January 2018

1 reference

Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways

21 January 2018

1 reference

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation.

21 January 2018

1 reference

mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function.

21 January 2018

1 reference

PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.

21 January 2018

1 reference

Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo

21 January 2018

1 reference

LAMTOR2 regulates dendritic cell homeostasis through FLT3-dependent mTOR signalling

21 January 2018

1 reference

Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function

21 January 2018

1 reference

The late endosomal adaptor molecule p14 (LAMTOR2) represents a novel regulator of Langerhans cell homeostasis

21 January 2018

1 reference

Rapamycin augments human DC IL-12p70 and IL-27 secretion to promote allogeneic Type 1 polarization modulated by NK cells

21 January 2018

1 reference

Convergence of the Mammalian Target of Rapamycin Complex 1- and Glycogen Synthase Kinase 3-β–Signaling Pathways Regulates the Innate Inflammatory Response

21 January 2018

1 reference

Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus

21 January 2018

1 reference

Comparative transcriptional and phenotypic peripheral blood analysis of kidney recipients under cyclosporin A or sirolimus monotherapy.

21 January 2018

1 reference

Mammalian target of rapamycin regulates IL-10 and resistance to Pseudomonas aeruginosa corneal infection

21 January 2018

1 reference

Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA.

21 January 2018

1 reference

Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1

21 January 2018

1 reference

Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide

21 January 2018

1 reference

mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo.

21 January 2018

1 reference

FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

21 January 2018

1 reference

Sirolimus interferes with the innate response to bacterial products in human whole blood by attenuation of IL-10 production

21 January 2018

1 reference

Rapamycin unbalances the polarization of human macrophages to M1.

21 January 2018

1 reference

LPS induces the degradation of programmed cell death protein 4 (PDCD4) to release Twist2, activating c-Maf transcription to promote interleukin-10 production

21 January 2018

1 reference

Rapamycin-treated mature dendritic cells have a unique cytokine secretion profile and impaired allostimulatory capacity.

21 January 2018

1 reference

Immunoregulatory properties of rapamycin-conditioned monocyte-derived dendritic cells and their role in transplantation

21 January 2018

1 reference

Immunoregulatory functions of mTOR inhibition.

21 January 2018

1 reference

Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages

21 January 2018

1 reference

Translational regulation of specific mRNAs controls feedback inhibition and survival during macrophage activation

21 January 2018

1 reference

Translational control of the innate immune response through IRF-7

21 January 2018

1 reference

Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

21 January 2018

1 reference

Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection

21 January 2018

1 reference

The antiviral immune response in human conventional dendritic cells is controlled by the mammalian target of rapamycin

21 January 2018

1 reference

Macrophage activation and polarization: nomenclature and experimental guidelines

21 January 2018

1 reference

Dynamic, M2-like remodeling phenotypes of CD11c adipose tissue macrophages during high-fat diet--induced obesity in mice

21 January 2018

1 reference

Macrophage-mediated inflammation in metabolic disease

21 January 2018

1 reference

Alternative activation of macrophages by IL-4 requires SHIP degradation.

21 January 2018

1 reference

Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation

21 January 2018

1 reference

Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses

21 January 2018

1 reference

Macrophage-Induced Tumor Angiogenesis Is Regulated by the TSC2–mTOR Pathway

21 January 2018

1 reference

SMAD-PI3K-Akt-mTOR pathway mediates BMP-7 polarization of monocytes into M2 macrophages

21 January 2018

1 reference

Tsc1 is a Critical Regulator of Macrophage Survival and Function

21 January 2018

1 reference

Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice.

21 January 2018

1 reference

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

21 January 2018

1 reference

Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice

21 January 2018

1 reference

Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance.

21 January 2018

1 reference

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

21 January 2018

1 reference

Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism

21 January 2018

1 reference

Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology

21 January 2018

1 reference

Dendritic cell reprogramming by endogenously produced lactic acid.

21 January 2018

1 reference

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

21 January 2018

1 reference

Macrophages: supportive cells for tissue repair and regeneration.

21 January 2018

1 reference

Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection

21 January 2018

1 reference

Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors

21 January 2018

1 reference

Spatial coupling of mTOR and autophagy augments secretory phenotypes.

21 January 2018

1 reference

CaMKIV-dependent preservation of mTOR expression is required for autophagy during lipopolysaccharide-induced inflammation and acute kidney injury

21 January 2018

1 reference

Termination of autophagy and reformation of lysosomes regulated by mTOR

21 January 2018

1 reference

Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages

21 January 2018

1 reference

MicroRNA-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb

21 January 2018

1 reference

Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole

21 January 2018

1 reference

Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages

21 January 2018

1 reference

Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages

21 January 2018

1 reference

Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses

21 January 2018

1 reference

Self-eating in the plaque: what macrophage autophagy reveals about atherosclerosis

21 January 2018

1 reference

Wip1-dependent regulation of autophagy, obesity, and atherosclerosis.

21 January 2018

1 reference

Selective inhibition of PI3K/Akt/mTOR signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaque

21 January 2018

1 reference

Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis

21 January 2018

1 reference

Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels

21 January 2018

1 reference

Modulation of antigen presentation by intracellular trafficking.

21 January 2018

1 reference

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

21 January 2018

1 reference

Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells

21 January 2018

1 reference

21 January 2018

TOR in the immune system

1 reference

Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction

21 January 2018

1 reference

Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival

21 January 2018

1 reference

Differential Effects of Immunosuppressive Drugs on Chemokine Receptor CCR7 in Human Monocyte-Derived Dendritic Cells: Selective Upregulation by Rapamycin

21 January 2018

1 reference

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

21 January 2018

1 reference

Everolimus inhibits monocyte/macrophage migration in vitro and their accumulation in carotid lesions of cholesterol-fed rabbits.

21 January 2018

1 reference

TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

21 January 2018

1 reference

PSGL-1 and mTOR regulate translation of ROCK-1 and physiological functions of macrophages

21 January 2018

1 reference

Neutrophil recruitment and function in health and inflammation

21 January 2018

1 reference

Review series: TOR kinase complexes and cell migration

21 January 2018

1 reference

Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton

21 January 2018

1 reference

mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion

21 January 2018

1 reference

Akt isoforms differentially regulate neutrophil functions

21 January 2018

1 reference

PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils

21 January 2018

1 reference

Rapamycin inhibits GM-CSF-induced neutrophil migration

21 January 2018

1 reference

Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling

21 January 2018

1 reference

Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation

21 January 2018

1 reference

Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs.

21 January 2018

1 reference

IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation

21 January 2018

1 reference

Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α

21 January 2018

1 reference

Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy

21 January 2018

1 reference

Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A

21 January 2018

1 reference

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

21 January 2018

1 reference

Effect of everolimus on the immunomodulation of the human neutrophil inflammatory response and activation

21 January 2018

1 reference

Protective and pathological roles of mast cells and basophils

21 January 2018

1 reference

Activation and function of the mTORC1 pathway in mast cells

21 January 2018

1 reference

Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release

21 January 2018

1 reference

mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells

21 January 2018

1 reference

Regulation of mast cell survival and function by tuberous sclerosis complex 1

21 January 2018

1 reference

Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation

21 January 2018

1 reference

Organ-specific features of natural killer cells

21 January 2018

1 reference

The Critical Role of IL-15-PI3K-mTOR Pathway in Natural Killer Cell Effector Functions

21 January 2018

1 reference

PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness

21 January 2018

1 reference

Rapamycin, but not cyclosporine or FK506, alters natural killer cell function.

21 January 2018

1 reference

IL-33 induces innate lymphoid cell-mediated airway inflammation by activating mammalian target of rapamycin

21 January 2018

1 reference

Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes

21 January 2018

1 reference

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

21 January 2018

1 reference

Mechanistic target of rapamycin inhibitors in solid organ transplantation: from benchside to clinical use.

21 January 2018

1 reference

Meta-analysis of long-term clinical outcomes of everolimus-eluting stents

21 January 2018

1 reference

Current treatment strategies for inhibiting mTOR in cancer

21 January 2018

1 reference

Recent advances in the genetic analysis of PTEN and PI3K innate immune properties

21 January 2018

1 reference

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

21 January 2018

1 reference

Non‐canonical functions of the tuberous sclerosis complex‐Rheb signalling axis

21 January 2018

1 reference

p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin

21 January 2018

1 reference

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling

21 January 2018

1 reference

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

21 January 2018

1 reference

Rapamycin inhibition of eosinophil differentiation attenuates allergic airway inflammation in mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6095456

Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6095456

Metabolic reprograming in macrophage polarization.

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6095456

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6095456

PI3K-mediated negative feedback regulation of IL-12 production in DCs

4 November 2018

1 reference

Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages

31 March 2020

1 reference

Cutting edge: mTORC1 in intestinal CD11c CD11b dendritic cells regulates intestinal homeostasis by promoting IL-10 production

31 March 2020

1 reference

Mannan and peptidoglycan induce COX-2 protein in human PMNvia the mammalian target of rapamycin

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI3901

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26403194 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 June 2020

1007525476

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Fatcat ID

release_krgqthao6zfqndhw3i67i3outm

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26403194 AND SRC:MED&resulttype=core&format=json

3 June 2020

26403194

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26403194 AND SRC:MED&resulttype=core&format=json