Immune deficiency vs. immune excess in inflammatory bowel diseases-STAT3 as a rheo-STAT of intestinal homeostasis (Q38558749)

4 September 2017

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title

Immune deficiency vs. immune excess in inflammatory bowel diseases-STAT3 as a rheo-STAT of intestinal homeostasis (English)

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inflammatory bowel diseases

4 September 2017

main subject

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2

Markus F Neurath

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4 September 2017

Moritz Leppkes

1

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4 September 2017

Martin Herrmann

series ordinal

3

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4 September 2017

Christoph Becker

series ordinal

4

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4 September 2017

publication date

31 July 2015

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Journal of Leukocyte Biology

4 September 2017

number of pages

10

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based on heuristic

inferred from page(s)

published in

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4 September 2017

volume

99

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4 September 2017

issue

1

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4 September 2017

page(s)

57-66

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Inflammatory bowel disease

4 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

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21 January 2018

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21 January 2018

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Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort

21 January 2018

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XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

21 January 2018

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Revisiting Crohn's disease as a primary immunodeficiency of macrophages

21 January 2018

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Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity

21 January 2018

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Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis

21 January 2018

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Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation

21 January 2018

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The diagnostic approach to monogenic very early onset inflammatory bowel disease

21 January 2018

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New mechanism of oral immunity to mucosal candidiasis in hyper-IgE syndrome

21 January 2018

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Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells

21 January 2018

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Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract

21 January 2018

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Phagocyte dysfunction and inflammatory bowel disease

21 January 2018

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Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America.

21 January 2018

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Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data

21 January 2018

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Vedolizumab for induction and maintenance of remission in ulcerative colitis: a Cochrane systematic review and meta-analysis

21 January 2018

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The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ⁺CD8αα⁺ cells.

21 January 2018

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Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection

21 January 2018

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https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Noncanonical STAT3 activation regulates excess TGF-β1 and collagen I expression in muscle of stricturing Crohn's disease

21 January 2018

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Somatic STAT3 mutations in large granular lymphocytic leukemia

21 January 2018

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Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

21 January 2018

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Blau syndrome, the prototypic auto-inflammatory granulomatous disease

21 January 2018

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Gastrointestinal involvement in chronic granulomatous disease

21 January 2018

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https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Clinical spectrum of X-linked hyper-IgM syndrome

21 January 2018

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https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency

21 January 2018

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https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Clinical outcome in IL-10- and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Digestive histopathological presentation of IPEX syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease.

21 January 2018

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https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency.

21 January 2018

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Second messenger role for Mg2 revealed by human T-cell immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Mutation in the TCRα subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRαβ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Chemically induced mouse models of intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

The STAT3 isoforms alpha and beta have unique and specific functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Stat3 dimerization regulated by reversible acetylation of a single lysine residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

STAT3-driven transcription depends upon the dimethylation of K49 by EZH2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Specific Inhibition of Stat3 Signal Transduction by PIAS3

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

STAT3 genotypic variation and cellular STAT3 activation and colon leukocyte recruitment in pediatric Crohn disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Surface area of the digestive tract - revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

The gut flora as a forgotten organ

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Immune adaptations that maintain homeostasis with the intestinal microbiota

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

The biology of innate lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

The development of LTi cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Pleiotropic functions of TNF-α in the regulation of the intestinal epithelial response to inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Intestinal epithelial cells: regulators of barrier function and immune homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Epithelial antimicrobial peptides in host defense against infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Paneth cells as a site of origin for intestinal inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

A new look at Crohn's disease: breakdown of the mucosal antibacterial defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Activation of intestinal epithelial Stat3 orchestrates tissue defense during gastrointestinal infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Absolute requirement for STAT3 function in small-intestine crypt stem cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Deletion of intestinal epithelial cell STAT3 promotes T-lymphocyte STAT3 activation and chronic colitis following acute dextran sodium sulfate injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease: Figure 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Neutrophil dysfunction in Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Candidacidal activity of Crohn's disease neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Interleukin-10-deficient mice develop chronic enterocolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Stat3 in resident macrophages as a repressor protein of inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Controlling the frontier: regulatory T-cells and intestinal homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Regulatory interactions between CD45RBhigh and CD45RBlow CD4 T cells are important for the balance between protective and pathogenic cell-mediated immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Transforming growth factor beta induced FoxP3 regulatory T cells suppress Th1 mediated experimental colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

CD4 regulatory T cells control TH17 responses in a Stat3-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

CD4 T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

PIAS3 suppresses acute graft-versus-host disease by modulating effector T and B cell subsets through inhibition of STAT3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

STAT3 activation in Th17 and Th22 cells controls IL-22-mediated epithelial host defense during infectious colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Stat3 activation in murine colitis induced by enterotoxigenic Bacteroides fragilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

The B-cell system in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Multi-faceted functions of secretory IgA at mucosal surfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

21 January 2018

Selective IgA deficiency

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Hyperactivated B cells in human inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

IL-10–Producing Regulatory B10 Cells Inhibit Intestinal Injury in a Mouse Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Exacerbation of ulcerative colitis after rituximab salvage therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

Epithelial NEMO links innate immunity to chronic intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189/JLB.5MR0515-221R

21 January 2018

Identifiers

DOI

10.1189/JLB.5MR0515-221R

1 reference

4 September 2017

1 reference