Etiopathogenesis of primary biliary cirrhosis: an overview of recent developments. (Q38552201)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201620 AND SRC:MED&resulttype=core&format=json

20 February 2020

title

Etiopathogenesis of primary biliary cirrhosis: an overview of recent developments (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201620 AND SRC:MED&resulttype=core&format=json

primary biliary cholangitis

20 February 2020

main subject

0 references

author

Palak Trivedi

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201620 AND SRC:MED&resulttype=core&format=json

20 February 2020

author name string

Sue Cullen

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201620 AND SRC:MED&resulttype=core&format=json

20 February 2020

publication date

20 March 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201620 AND SRC:MED&resulttype=core&format=json

20 February 2020

published in

Hepatology international

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201620 AND SRC:MED&resulttype=core&format=json

20 February 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201620 AND SRC:MED&resulttype=core&format=json

20 February 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201620 AND SRC:MED&resulttype=core&format=json

20 February 2020

page(s)

28-47

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The epidemiology of primary biliary cirrhosis

20 February 2020

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

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The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes

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21 January 2018

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Comparative analysis of portal cell infiltrates in antimitochondrial autoantibody-positive versus antimitochondrial autoantibody-negative primary biliary cirrhosis

21 January 2018

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Gender as risk factor for autoimmune diseases

21 January 2018

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Frequency of monosomy X in women with primary biliary cirrhosis.

21 January 2018

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Preferential X chromosome loss but random inactivation characterize primary biliary cirrhosis

21 January 2018

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Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis

21 January 2018

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21 January 2018

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Immune response to lipopolysaccharide in primary biliary cirrhosis and autoimmune diseases

21 January 2018

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Mycoplasma antigens as a possible trigger for the induction of antimitochondrial antibodies in primary biliary cirrhosis.

21 January 2018

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Relation between Escherichia coli R(rough)-forms in gut, lipid A in liver, and primary biliary cirrhosis

21 January 2018

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Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis.

21 January 2018

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Association between the primary biliary cirrhosis specific anti-sp100 antibodies and recurrent urinary tract infection.

21 January 2018

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Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium

21 January 2018

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Liver autoimmunity triggered by microbial activation of natural killer T cells

21 January 2018

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Does a betaretrovirus infection trigger primary biliary cirrhosis?

21 January 2018

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https://api.crossref.org/works/10.1007/S12072-012-9362-7

Mouse mammary tumor virus in anti-mitochondrial antibody producing mouse models

21 January 2018

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https://api.crossref.org/works/10.1007/S12072-012-9362-7

Cyclosporine A inhibits in vitro replication of betaretrovirus associated with primary biliary cirrhosis

21 January 2018

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Detection of retroviral antibodies in primary biliary cirrhosis and other idiopathic biliary disorders

21 January 2018

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Mouse mammary tumour virus-like virus (MMTV-LV) is present within the liver in a wide range of hepatic disorders and unrelated to nuclear p53 expression or hepatocarcinogenesis

21 January 2018

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Lack of immunological or molecular evidence for a role of mouse mammary tumor retrovirus in primary biliary cirrhosis

21 January 2018

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Pilot studies of single and combination antiretroviral therapy in patients with primary biliary cirrhosis

21 January 2018

1 reference

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Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway

21 January 2018

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Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis

21 January 2018

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Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis

21 January 2018

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21 January 2018

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21 January 2018

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Signalling of the M3-muscarinic receptor to the anti-apoptotic pathway

21 January 2018

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Interferon gamma accelerates NF-kappaB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction

21 January 2018

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Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis

21 January 2018

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Apotopes and the biliary specificity of primary biliary cirrhosis

21 January 2018

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Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease

21 January 2018

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A blast from the past: clearance of apoptotic cells regulates immune responses.

21 January 2018

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Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent.

21 January 2018

1 reference

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Bile acids: regulation of apoptosis by ursodeoxycholic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Transgenic mice aberrantly expressing pyruvate dehydrogenase complex E2 component on biliary epithelial cells do not show primary biliary cirrhosis

21 January 2018

1 reference

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Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis

21 January 2018

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Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs

21 January 2018

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Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

21 January 2018

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Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis

21 January 2018

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Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis

21 January 2018

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Lipopolysaccharide Activates Nuclear Factor-KappaB through Toll-Like Receptors and Related Molecules in Cultured Biliary Epithelial Cells

21 January 2018

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Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation

21 January 2018

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AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers

21 January 2018

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Bacterial CpG induces hyper-IgM production in CD27( ) memory B cells in primary biliary cirrhosis

21 January 2018

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Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis

21 January 2018

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Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis

21 January 2018

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Differential expression of intestinal trefoil factor in biliary epithelial cells of primary biliary cirrhosis

21 January 2018

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Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis

21 January 2018

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Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population

21 January 2018

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Hepatic IL-17 responses in human and murine primary biliary cirrhosis

21 January 2018

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Identification of HLA-A2-restricted CD8( ) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells

21 January 2018

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Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa

21 January 2018

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Adoptive transfer of CD8( ) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice

21 January 2018

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Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis

21 January 2018

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PSC, AIH and overlap syndrome in inflammatory bowel disease

21 January 2018

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IL-2 receptor alpha deficiency and features of primary biliary cirrhosis

21 January 2018

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Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis.

21 January 2018

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Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis

21 January 2018

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CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection

21 January 2018

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New insights on the molecular and cell biology of human cholangiopathies

21 January 2018

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PDGF-mediated chemoattraction of hepatic stellate cells by bile duct segments in cholestatic liver injury

21 January 2018

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Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2.

21 January 2018

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Defective regulation of cholangiocyte Cl-/HCO3(-) and Na /H exchanger activities in primary biliary cirrhosis.

21 January 2018

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Loss of Inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis

21 January 2018

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On the role and fate of LPS-dephosphorylating activity in the rat liver

21 January 2018

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A review of defensins of diverse origins

21 January 2018

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21 January 2018

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Proinflammatory cytokines inhibit secretion in rat bile duct epithelium.

21 January 2018

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Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis

21 January 2018

1 reference

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Sustained upregulation of sodium taurocholate cotransporting polypeptide and bile salt export pump and downregulation of cholesterol 7α-hydroxylase in the liver of patients with end-stage primary biliary cirrhosis

21 January 2018

1 reference

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Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases.

21 January 2018

1 reference

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Immunization of experimental animals with dihydrolipoamide acetyltransferase, as a purified recombinant polypeptide, generates mitochondrial antibodies but not primary biliary cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice

21 January 2018

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21 January 2018

1 reference

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A possible mouse model for spontaneous cholangitis: serological and histological characteristics of MRL/lpr mice

21 January 2018

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IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis

21 January 2018

1 reference

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Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis

21 January 2018

1 reference

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Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice

21 January 2018

1 reference

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TGF-beta1 maintains suppressor function and Foxp3 expression in CD4 CD25 regulatory T cells

21 January 2018

1 reference

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Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice

21 January 2018

1 reference

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B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

B cell depletion therapy exacerbates murine primary biliary cirrhosis

21 January 2018

1 reference

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Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells.

21 January 2018

1 reference

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A case for regulatory B cells

21 January 2018

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Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization

21 January 2018

1 reference

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Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis

21 January 2018

1 reference

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The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis

21 January 2018

1 reference

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Integrating pathway analysis and genetics of gene expression for genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Demonstration of autoantibodies to recombinant human sulphite oxidase in patients with chronic liver disorders and analysis of their clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

The peculiar autoimmunity of primary biliary cirrhosis

21 January 2018

2 references

https://api.crossref.org/works/10.1007/S12072-012-9362-7

21 January 2018

12 December 2020

Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Risk Factors and Prediction of Long-term Outcome in Primary Biliary Cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Autoantibodies as prognostic markers in autoimmune liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

PML nuclear body component Sp140 is a novel autoantigen in primary biliary cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Autoimmune cholangitis in NOD.c3c4 mice is associated with cholangiocyte-specific Fas antigen deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Activation of the IGF1 System Characterizes Cholangiocyte Survival During Progression of Primary Biliary Cirrhosis

21 January 2018

1 reference

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Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Demonstration of PDC-E1 subunits as major antigens in the complement-fixing fraction M4 and re-evaluation of PDC-E1-specific antibodies in PBC patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12072-012-9362-7

Dephosphorylation of endotoxin by alkaline phosphatase in vivo

21 January 2018

1 reference

12 December 2020

Assessment of biliary bicarbonate secretion in humans by positron emission tomography

1 reference

12 December 2020

Sequential and diagnostic features in primary biliary cirrhosis based on serial histologic study in 209 patients

1 reference

12 December 2020

Spontaneous occurrence of chronic non-suppurative destructive cholangitis and antimitochondrial autoantibodies in MRL/lpr mice: possible animal model for primary biliary cirrhosis

1 reference

12 December 2020

Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts

1 reference

12 December 2020

Characterization of recombinant monoclonal IgA anti-PDC-E2 autoantibodies derived from patients with PBC.

1 reference

12 December 2020

T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis

1 reference

12 December 2020

Antimitochondrial antibody profiles determined at early stages of primary biliary cirrhosis differentiate between a benign and a progressive course of the disease. A retrospective analysis of 76 patients over 6-18 years

1 reference

12 December 2020

Familial primary biliary cirrhosis reassessed: a geographically-based population study

1 reference

12 December 2020

The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis.

1 reference

12 December 2020

Characterization of biliary intra-epithelial lymphocytes at different anatomical levels of intrahepatic bile ducts under normal and pathological conditions: numbers of CD4 CD28- intra-epithelial lymphocytes are increased in primary biliary cirrhosis

1 reference

12 December 2020

Hepatic lesions induced by graft-versus-host reaction across MHC class II antigens: An implication for animal model of primary biliary cirrhosis

1 reference

12 December 2020

Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis

1 reference

12 December 2020

Human leukocyte antigen Class II associations in serum antimitochondrial antibodies (AMA)-positive and AMA-negative primary biliary cirrhosis

1 reference

12 December 2020

Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss

1 reference

12 December 2020

Bile duct cell apoptosis is a rare event in primary biliary cirrhosis

1 reference

12 December 2020

HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study

1 reference

12 December 2020

Demographic, lifestyle, medical and familial factors associated with primary biliary cirrhosis

1 reference

12 December 2020

The Role of CXCR3 in the Induction of Primary Biliary Cirrhosis

1 reference

12 December 2020

Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis

1 reference

12 December 2020

An exploratory population-based case-control study of primary biliary cirrhosis

1 reference

12 December 2020

Mitochondrial antigen/antibody systems in primary biliary cirrhosis: revisited

1 reference

12 December 2020

Replicated association of 17q12-21 with susceptibility of primary biliary cirrhosis in a Japanese cohort

1 reference

12 December 2020

Cytokine profile in the liver of primary biliary cirrhosis

1 reference

12 December 2020

Value of Autoantibody Analysis in the Differential Diagnosis of Chronic Cholestatic Liver Disease

1 reference

12 December 2020

Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatibility complex class II and BB1/B7 expression

1 reference

12 December 2020

Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis

1 reference

12 December 2020

Linking human beta retrovirus infection with primary biliary cirrhosis.

1 reference

12 December 2020

Clinical trial: randomized controlled study of zidovudine and lamivudine for patients with primary biliary cirrhosis stabilized on ursodiol

1 reference

12 December 2020

The value of antinuclear antibodies in primary biliary cirrhosis

1 reference

12 December 2020

Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking

1 reference

12 December 2020

Immune-mediated cholangiohepatitis in neonatally thymectomized mice: the role of T cells and analysis of T-cell receptor Vbeta usage

1 reference

12 December 2020

ATPase-associated antigen (M2): marker antigen for serological diagnosis of primary biliary cirrhosis

1 reference

12 December 2020

Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy

1 reference

12 December 2020

CD40 activation-induced, Fas-dependent apoptosis and NF-kappaB/AP-1 signaling in human intrahepatic biliary epithelial cells

1 reference

12 December 2020

Induction and persistence of immune-mediated cholangiohepatitis in neonatally thymectomized mice

1 reference

12 December 2020

Smoking as an independent risk factor of liver fibrosis in primary biliary cirrhosis

1 reference

12 December 2020

Estrogen receptors in cholangiocytes and the progression of primary biliary cirrhosis

1 reference

12 December 2020

Early development of primary biliary cirrhosis in female C57BL/6 mice because of poly I:C administration

1 reference

12 December 2020

Prevalence, kinetics, and therapeutic modulation of autoantibodies against Sp100 and promyelocytic leukemia protein in a large cohort of patients with primary biliary cirrhosis

1 reference

12 December 2020

Nuclear envelope protein autoantigens in primary biliary cirrhosis

1 reference

12 December 2020

Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis

1 reference

12 December 2020

Urinary tract infection as a risk factor for autoimmune liver disease: From bench to bedside

1 reference

12 December 2020

A physiologic function for alkaline phosphatase: endotoxin detoxification.

1 reference

12 December 2020

Expression of pyruvate-dehydrogenase complex PDC-E2 on biliary epithelial cells induced by lymph nodes from primary biliary cirrhosis

1 reference

12 December 2020

Analysis of HLA alleles polymorphism in Chinese patients with primary biliary cirrhosis.

1 reference

12 December 2020

The retroviral myth of primary biliary cirrhosis: is this (finally) the end of the story?

1 reference

12 December 2020

Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis

1 reference

12 December 2020

Two cases of inflammatory bowel disease diagnosed in the course of primary biliary cirrhosis

1 reference

12 December 2020

Prediction of prognosis of primary biliary cirrhosis in Japan

1 reference

12 December 2020

Clinical significance of anti-multiple nuclear dots/Sp100 autoantibodies

1 reference

12 December 2020

Increased prevalence of primary biliary cirrhosis near Superfund toxic waste sites

1 reference

12 December 2020

Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor

1 reference

12 December 2020

The evidence supports a viral aetiology for primary biliary cirrhosis

1 reference

12 December 2020

10.1007/S12072-012-9362-7

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201620 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

20 February 2020

1032387007

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26201620 AND SRC:MED&resulttype=core&format=json