p53 in survival, death and metabolic health: a lifeguard with a licence to kill (Q38540071)

3 September 2017

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title

p53 in survival, death and metabolic health: a lifeguard with a licence to kill (English)

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3 September 2017

1

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Karen Vousden

series ordinal

3

object named as

Karen H Vousden

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3 September 2017

author name string

Christiaan F Labuschagne

series ordinal

2

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3 September 2017

publication date

1 June 2015

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Nature Reviews Molecular Cell Biology

3 September 2017

published in

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3 September 2017

volume

16

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3 September 2017

issue

7

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3 September 2017

page(s)

393-405

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Transcriptional control of human p53-regulated genes

3 September 2017

cites work

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MicroRNAs in the p53 network: micromanagement of tumour suppression

31 March 2020

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Cytoplasmic functions of the tumour suppressor p53.

31 March 2020

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Another fork in the road--life or death decisions by the tumour suppressor p53

31 March 2020

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Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.

31 March 2020

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Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response

31 March 2020

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Surf the post-translational modification network of p53 regulation

31 March 2020

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31 March 2020

Modes of p53 regulation

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Mdm2 promotes the rapid degradation of p53

31 March 2020

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Regulation of p53 stability by Mdm2

31 March 2020

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The role of ubiquitin modification in the regulation of p53.

31 March 2020

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31 March 2020

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p53 mutant mice that display early ageing-associated phenotypes

31 March 2020

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Inappropriate p53 activation during development induces features of CHARGE syndrome

31 March 2020

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p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content

31 March 2020

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p53: the barrier to cancer stem cell formation.

31 March 2020

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p53 and its mutants in tumor cell migration and invasion

31 March 2020

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Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome.

31 March 2020

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Interactions between the tumor suppressor p53 and immune responses.

31 March 2020

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Involvement of stromal p53 in tumor-stroma interactions.

31 March 2020

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Non-cell-autonomous tumor suppression by p53.

31 March 2020

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Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

31 March 2020

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

31 March 2020

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Dissecting p53-dependent apoptosis.

31 March 2020

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No PUMA, no death: implications for p53-dependent apoptosis

31 March 2020

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The mitochondrial p53 pathway

31 March 2020

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The DNA-binding domain mediates both nuclear and cytosolic functions of p53

31 March 2020

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PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis

31 March 2020

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The transcriptional targets of p53 in apoptosis control

31 March 2020

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Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53.

31 March 2020

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Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

31 March 2020

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The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage

31 March 2020

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p53 opens the mitochondrial permeability transition pore to trigger necrosis

31 March 2020

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p53 regulates a non-apoptotic death induced by ROS.

31 March 2020

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Mitochondrial and nuclear cross talk in cell death: parthanatos

31 March 2020

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Murine Double Minute-2 Prevents p53-Overactivation-Related Cell Death (Podoptosis) of Podocytes.

31 March 2020

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Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

31 March 2020

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Telomere dysfunction and tumour suppression: the senescence connection

31 March 2020

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An oncogene-induced DNA damage model for cancer development

31 March 2020

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Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

31 March 2020

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Senescence and apoptosis: dueling or complementary cell fates?

31 March 2020

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Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

31 March 2020

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

31 March 2020

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Suppression of induced pluripotent stem cell generation by the p53-p21 pathway

31 March 2020

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p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer

31 March 2020

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Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals

31 March 2020

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WAF1, a potential mediator of p53 tumor suppression

31 March 2020

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

31 March 2020

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Radiation-induced cell cycle arrest compromised by p21 deficiency

31 March 2020

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p53: traffic cop at the crossroads of DNA repair and recombination

31 March 2020

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Centrosomes, chromosome instability (CIN) and aneuploidy

31 March 2020

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A centrosomal route for cancer genome instability

31 March 2020

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Metabolic regulation by p53.

31 March 2020

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

31 March 2020

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AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells.

31 March 2020

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AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity

31 March 2020

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A nucleocytoplasmic malate dehydrogenase regulates p53 transcriptional activity in response to metabolic stress

31 March 2020

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Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation

31 March 2020

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Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6

31 March 2020

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Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells.

31 March 2020

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Tumour-associated mutant p53 drives the Warburg effect

31 March 2020

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p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation

31 March 2020

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Modulation of intracellular ROS levels by TIGAR controls autophagy

31 March 2020

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

31 March 2020

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p53 regulates glucose metabolism by miR-34a.

31 March 2020

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p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2

31 March 2020

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Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

31 March 2020

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Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

31 March 2020

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Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

31 March 2020

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p53 regulates mitochondrial respiration

31 March 2020

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AIF, reactive oxygen species, and neurodegeneration: a "complex" problem

31 March 2020

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Regulation of AIF expression by p53.

31 March 2020

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p53 and mitochondrial function in neurons

31 March 2020

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Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis

31 March 2020

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p53 is necessary for the adaptive changes in cellular milieu subsequent to an acute bout of endurance exercise.

31 March 2020

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Metabolic regulation by p53 family members.

31 March 2020

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Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53

31 March 2020

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p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

31 March 2020

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Telomere dysfunction induces metabolic and mitochondrial compromise.

31 March 2020

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p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production

31 March 2020

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p53-Dependent regulation of metabolic function through transcriptional activation of pantothenate kinase-1 gene

31 March 2020

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Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.

31 March 2020

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Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

31 March 2020

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The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation

31 March 2020

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

31 March 2020

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Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells.

31 March 2020

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Quantitative flux analysis reveals folate-dependent NADPH production.

31 March 2020

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Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism

31 March 2020

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Serine is a natural ligand and allosteric activator of pyruvate kinase M2

31 March 2020

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Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model

31 March 2020

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ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress

31 March 2020

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Cellular fatty acid metabolism and cancer

31 March 2020

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Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy.

31 March 2020

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Dissecting the pathways that destabilize mutant p53: the proteasome or autophagy?

31 March 2020

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DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

31 March 2020

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Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

31 March 2020

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TRP53 activates a global autophagy program to promote tumor suppression

31 March 2020

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Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress

31 March 2020

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p53 status determines the role of autophagy in pancreatic tumour development

31 March 2020

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Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

31 March 2020

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Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations

31 March 2020

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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

31 March 2020

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The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

31 March 2020

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p53 represses autophagy in a cell cycle-dependent fashion

31 March 2020

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p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.

31 March 2020

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p53/HMGB1 complexes regulate autophagy and apoptosis.

31 March 2020

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Redox regulation of p53, redox effectors regulated by p53: a subtle balance

31 March 2020

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TIGAR has a dual role in cancer cell survival through regulating apoptosis and autophagy

31 March 2020

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A TIGAR-regulated metabolic pathway is critical for protection of brain ischemia

31 March 2020

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Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

31 March 2020

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Molecular pathways: tumor cells Co-opt the brain-specific metabolism gene CPT1C to promote survival

31 March 2020

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The guardian recruits cops: the p53-p21 axis delegates prosurvival duties to the Keap1-Nrf2 stress pathway

31 March 2020

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Reciprocal down-regulation of p53 and SOD2 gene expression-implication in p53 mediated apoptosis

31 March 2020

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Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses

31 March 2020

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p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.

31 March 2020

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p53 suppresses the Nrf2-dependent transcription of antioxidant response genes.

31 March 2020

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A model for p53-induced apoptosis

31 March 2020

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The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway

31 March 2020

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Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

31 March 2020

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Blinded by the Light: The Growing Complexity of p53

31 March 2020

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Decision making of the p53 network: death by integration

31 March 2020

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TIGAR is required for efficient intestinal regeneration and tumorigenesis

31 March 2020

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31 March 2020

Gone but not forgotten

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Selective activation of p53-mediated tumour suppression in high-grade tumours

31 March 2020

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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

31 March 2020

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p53 dynamics control cell fate

31 March 2020

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A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis

31 March 2020

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How p53 wields the scales of fate: arrest or death?

31 March 2020

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DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.

31 March 2020

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Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression

31 March 2020

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Transcriptional regulation by p53.

31 March 2020

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Living with p53, dying of p53.

31 March 2020

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The impact of post-transcriptional regulation in the p53 network

31 March 2020

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Transcriptional and epigenetic regulation of the p53 tumor suppressor gene

31 March 2020

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Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence

31 March 2020

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

31 March 2020

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High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.

31 March 2020

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ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.

31 March 2020

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p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

31 March 2020

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Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages

31 March 2020

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p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo.

31 March 2020

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Modeling the therapeutic efficacy of p53 restoration in tumors

31 March 2020

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Restoration of p53 function leads to tumour regression in vivo

31 March 2020

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

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Targeting antioxidants for cancer therapy

31 March 2020

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Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability

31 March 2020

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p53-mediated hematopoietic stem and progenitor cell competition.

31 March 2020

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p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.

31 March 2020

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p53 in breast cancer subtypes and new insights into response to chemotherapy

31 March 2020

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Mechanisms of action of Bcl-2 family proteins

31 March 2020

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

31 March 2020

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A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

31 March 2020

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The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

31 March 2020

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

31 March 2020

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Glutamine and cancer: cell biology, physiology, and clinical opportunities

31 March 2020

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Reductive carboxylation supports growth in tumour cells with defective mitochondria.

31 March 2020

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Autophagy: renovation of cells and tissues

31 March 2020

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To be or not to be? How selective autophagy and cell death govern cell fate

31 March 2020

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Mammalian autophagy: core molecular machinery and signaling regulation

31 March 2020

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Self-consumption: the interplay of autophagy and apoptosis

31 March 2020

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Autophagy-deficient mice develop multiple liver tumors

31 March 2020

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Induction of autophagy and inhibition of tumorigenesis by beclin 1

31 March 2020

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

31 March 2020

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Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

31 March 2020

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Pancreatic cancers require autophagy for tumor growth

31 March 2020

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Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

31 March 2020

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ROS-dependent signal transduction

31 March 2020

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Modulation of oxidative stress as an anticancer strategy

31 March 2020

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Ferroptosis as a p53-mediated activity during tumour suppression

31 March 2020

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Glycolytic enzymes can modulate cellular life span

31 March 2020

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12 December 2020

Involvement of p53 in cell differentiation and development

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12 December 2020

Massively regulated genes: the example of TP53.

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12 December 2020

p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression.

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12 December 2020

The p53 circuit board

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12 December 2020

A dual role for autophagy in a murine model of lung cancer

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12 December 2020

Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability

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12 December 2020

Identifiers

DOI

10.1038/NRM4007

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Dimensions Publication ID

3 September 2017

1042853208

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Fatcat ID

release_y7u4aapajrfnxkjfcxpgu2fgy4

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Fatcat

https://api.fatcat.wiki/v0/release/y7u4aapajrfnxkjfcxpgu2fgy4

24 November 2022

mapped directly with Wikidata item

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