Compromised autophagy and neurodegenerative diseases (Q38492623)

3 September 2017

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title

Compromised autophagy and neurodegenerative diseases (English)

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3 September 2017

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25991442 AND SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Fiona M Menzies

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25991442 AND SRC:MED&resulttype=core&format=json

11 June 2020

David C Rubinsztein

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25991442 AND SRC:MED&resulttype=core&format=json

11 June 2020

language of work or name

English

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publication date

1 June 2015

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Nature Reviews Neuroscience

3 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25991442 AND SRC:MED&resulttype=core&format=json

11 June 2020

volume

16

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25991442 AND SRC:MED&resulttype=core&format=json

11 June 2020

issue

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25991442 AND SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

345-357

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25991442 AND SRC:MED&resulttype=core&format=json

Huntington's disease: from pathology and genetics to potential therapies

11 June 2020

cites work

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The roles of intracellular protein-degradation pathways in neurodegeneration

31 March 2020

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Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.

31 March 2020

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

31 March 2020

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

31 March 2020

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Mitophagy Selectively Degrades Individual Damaged Mitochondria After Photoirradiation

31 March 2020

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Inhibition of macroautophagy triggers apoptosis

31 March 2020

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Rapamycin pre-treatment protects against apoptosis

31 March 2020

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Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

31 March 2020

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Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae

31 March 2020

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Autophagy fights disease through cellular self-digestion

31 March 2020

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Plasma membrane contributes to the formation of pre-autophagosomal structures

31 March 2020

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A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

31 March 2020

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3D tomography reveals connections between the phagophore and endoplasmic reticulum

31 March 2020

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Exit from the Golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae

31 March 2020

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The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy

31 March 2020

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Mitochondria supply membranes for autophagosome biogenesis during starvation

31 March 2020

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Diverse autophagosome membrane sources coalesce in recycling endosomes.

31 March 2020

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

31 March 2020

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Dynein mutations impair autophagic clearance of aggregate-prone proteins

31 March 2020

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Autophagosome Precursor Maturation Requires Homotypic Fusion

31 March 2020

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TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

31 March 2020

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Cellular machinery to fuse antimicrobial autophagosome with lysosome

31 March 2020

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Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

31 March 2020

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The return of the nucleus: transcriptional and epigenetic control of autophagy

31 March 2020

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p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.

31 March 2020

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ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.

31 March 2020

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WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.

31 March 2020

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AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization

31 March 2020

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Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase.

31 March 2020

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PI(5)P regulates autophagosome biogenesis

31 March 2020

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Cargo recognition and trafficking in selective autophagy

31 March 2020

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

31 March 2020

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A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

31 March 2020

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

31 March 2020

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Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy.

31 March 2020

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Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

31 March 2020

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The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy

31 March 2020

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p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

31 March 2020

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Nix is a selective autophagy receptor for mitochondrial clearance

31 March 2020

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Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy

31 March 2020

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At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy.

31 March 2020

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The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation

31 March 2020

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Connections between SNAREs and autophagy

31 March 2020

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Termination of autophagy and reformation of lysosomes regulated by mTOR

31 March 2020

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A gene network regulating lysosomal biogenesis and function

31 March 2020

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TFEB links autophagy to lysosomal biogenesis

31 March 2020

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Autophagy and neurodegeneration

31 March 2020

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BPAN: the only X-linked dominant NBIA disorder

31 March 2020

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De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

31 March 2020

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Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.

31 March 2020

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Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7.

31 March 2020

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The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients

31 March 2020

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Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway

31 March 2020

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Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

31 March 2020

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Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy

31 March 2020

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A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis

31 March 2020

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Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15

31 March 2020

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

31 March 2020

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Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes

31 March 2020

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Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains

31 March 2020

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PICALM modulates autophagy activity and tau accumulation

31 March 2020

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The autophagic roles of Rab small GTPases and their upstream regulators: a review

31 March 2020

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Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy

31 March 2020

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The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

31 March 2020

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Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor

31 March 2020

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Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

31 March 2020

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Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation

31 March 2020

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The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs

31 March 2020

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C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

31 March 2020

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C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

31 March 2020

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Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

31 March 2020

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ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration

31 March 2020

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The retromer complex - endosomal protein recycling and beyond

31 March 2020

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Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy

31 March 2020

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A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

31 March 2020

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α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

31 March 2020

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alpha-Synuclein locus triplication causes Parkinson's disease

31 March 2020

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

31 March 2020

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The hereditary spastic paraplegia protein strumpellin: characterisation in neurons and of the effect of disease mutations on WASH complex assembly and function

31 March 2020

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Identification of a novel candidate gene for non-syndromic autosomal recessive intellectual disability: the WASH complex member SWIP.

31 March 2020

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DNAJC13 mutations in Parkinson disease

31 March 2020

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A mutation in sigma‐1 receptor causes juvenile amyotrophic lateral sclerosis

31 March 2020

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Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease.

31 March 2020

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Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis

31 March 2020

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The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study

31 March 2020

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Sigma-1R agonist improves motor function and motoneuron survival in ALS mice

31 March 2020

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Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances

31 March 2020

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Autophagy in lysosomal storage disorders

31 March 2020

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The association between ß-glucocerebrosidase mutations and parkinsonism

31 March 2020

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Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease

31 March 2020

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

31 March 2020

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Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease

31 March 2020

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Lysosomal membrane permeabilization in cell death

31 March 2020

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High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A.

31 March 2020

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Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

31 March 2020

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Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration.

31 March 2020

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

31 March 2020

1 reference

Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies

31 March 2020

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A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.

31 March 2020

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Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells.

31 March 2020

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Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons

31 March 2020

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Presenilin Is Necessary for Efficient Proteolysis through the Autophagy–Lysosome System in a γ-Secretase-Independent Manner

31 March 2020

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Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.

31 March 2020

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TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

31 March 2020

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Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease

31 March 2020

1 reference

Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation

31 March 2020

1 reference

p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases

31 March 2020

1 reference

Optineurin immunoreactivity in neuronal nuclear inclusions of polyglutamine diseases (Huntington's, DRPLA, SCA2, SCA3) and intranuclear inclusion body disease

31 March 2020

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Mutations of optineurin in amyotrophic lateral sclerosis

31 March 2020

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p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies

31 March 2020

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p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model.

31 March 2020

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Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice

31 March 2020

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Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family

31 March 2020

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p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate

31 March 2020

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The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

31 March 2020

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Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.

31 March 2020

1 reference

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

31 March 2020

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Huntingtin functions as a scaffold for selective macroautophagy

31 March 2020

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SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis

31 March 2020

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Mutations in SQSTM1 encoding p62 in amyotrophic lateral sclerosis: genetics and neuropathology

31 March 2020

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Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

31 March 2020

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Control of autophagy as a therapy for neurodegenerative disease

31 March 2020

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Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice.

31 March 2020

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

31 March 2020

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Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

31 March 2020

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

31 March 2020

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Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease

31 March 2020

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Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

31 March 2020

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Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

31 March 2020

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Lithium induces autophagy by inhibiting inositol monophosphatase

31 March 2020

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Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: implications of autophagy promotion

31 March 2020

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Autophagy enhancer carbamazepine alleviates memory deficits and cerebral amyloid-β pathology in a mouse model of Alzheimer's disease

31 March 2020

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Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.

31 March 2020

1 reference

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

31 March 2020

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Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

31 March 2020

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Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

31 March 2020

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Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

31 March 2020

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MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.

31 March 2020

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Transcriptional activation of lysosomal exocytosis promotes cellular clearance

31 March 2020

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Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

31 March 2020

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Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

31 March 2020

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Measurement of autophagy flux in the nervous system in vivo

31 March 2020

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Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

31 March 2020

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Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease

31 March 2020

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

31 March 2020

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

31 March 2020

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

31 March 2020

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Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode

31 March 2020

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Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

31 March 2020

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Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

31 March 2020

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

31 March 2020

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

31 March 2020

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

31 March 2020

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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

31 March 2020

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Mitophagy and Parkinson's disease: be eaten to stay healthy

31 March 2020

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The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

31 March 2020

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p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

31 March 2020

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Parkin and PINK1: much more than mitophagy

31 March 2020

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Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

31 March 2020

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Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

31 March 2020

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Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease

31 March 2020

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Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

31 March 2020

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Defective mitophagy in XPA via PARP-1 hyperactivation and NAD( )/SIRT1 reduction.

31 March 2020

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Chaperone-mediated autophagy: roles in disease and aging

31 March 2020

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Chaperone-mediated autophagy: roles in neurodegeneration

31 March 2020

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Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases

31 March 2020

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

31 March 2020

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Interplay of LRRK2 with chaperone-mediated autophagy

31 March 2020

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Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

31 March 2020

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The pathogenesis of Niemann-Pick type C disease: a role for autophagy?

31 March 2020

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Correction: Uncoupling of Longevity and Telomere Length in C. elegans

31 March 2020

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Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

31 March 2020

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Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease

31 March 2020

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Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1

31 March 2020

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Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells.

31 March 2020

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Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease

31 March 2020

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The autophagic defect in Niemann-Pick disease type C neurons differs from somatic cells and reduces neuronal viability.

31 March 2020

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Inflammation-induced alteration of astrocyte mitochondrial dynamics requires autophagy for mitochondrial network maintenance

31 March 2020

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Autophagy promotes oligodendrocyte survival and function following dysmyelination in a long-lived myelin mutant

31 March 2020

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Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice

31 March 2020

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Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

31 March 2020

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Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation

31 March 2020

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Prion-like propagation of protein aggregation and related therapeutic strategies

31 March 2020

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Exosomal cell-to-cell transmission of alpha synuclein oligomers.

31 March 2020

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Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion

31 March 2020

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Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein.

31 March 2020

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Aβ secretion and plaque formation depend on autophagy

31 March 2020

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