An in vitro evaluation of guanfacine as a substrate for P-glycoprotein. (Q38416672)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21931492 AND SRC:MED&resulttype=core&format=json

13 February 2020

title

An in vitro evaluation of guanfacine as a substrate for P-glycoprotein (English)

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13 February 2020

1

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13 February 2020

author name string

Hao-Jie Zhu

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21931492 AND SRC:MED&resulttype=core&format=json

13 February 2020

John S Markowitz

series ordinal

3

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13 February 2020

language of work or name

English

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publication date

26 August 2011

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Neuropsychiatric Disease and Treatment

13 February 2020

published in

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13 February 2020

volume

7

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13 February 2020

page(s)

501-505

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Creative Commons Attribution-NonCommercial 3.0 Unported

13 February 2020

copyright license

start time

1 August 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Possible influence of variant of the P-glycoprotein gene (MDR1/ABCB1) on clinical response to guanfacine in children with pervasive developmental disorders and hyperactivity

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Interactions of attention-deficit/hyperactivity disorder therapeutic agents with the efflux transporter P-glycoprotein

6 September 2017

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A "silent" polymorphism in the MDR1 gene changes substrate specificity

6 September 2017

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Microplate screening of the differential effects of test agents on Hoechst 33342, rhodamine 123, and rhodamine 6G accumulation in breast cancer cells that overexpress P-glycoprotein

6 September 2017

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Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

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6 September 2017

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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

6 September 2017

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Guanfacine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension

6 September 2017

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Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

14 September 2017

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Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

14 September 2017

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Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

14 September 2017

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The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes

27 September 2017

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A randomized, double-blind, placebo-controlled study of guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder

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A prospective open trial of guanfacine in children with pervasive developmental disorders

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Risperidone and paliperidone inhibit p-glycoprotein activity in vitro

31 August 2018

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The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein

31 August 2018

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Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood-brain barrier of Abcb1a gene knockout mice

31 August 2018

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Olanzapine penetration into brain is greater in transgenic Abcb1a P-glycoprotein-deficient mice than FVB1 (wild-type) animals

31 August 2018

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Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-Glycoprotein gene disruption

31 August 2018

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31 August 2018

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A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder

31 August 2018

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The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task

31 August 2018

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31 August 2018

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12 December 2020

A topological substructural approach for the prediction of P-glycoprotein substrates

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12 December 2020

The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56 natural killer cells

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12 December 2020

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12 December 2020

Identifiers

DOI

10.2147/NDT.S24153

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21931492 AND SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21931492 AND SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

21931492

1 reference