Genomics in acute lymphoblastic leukaemia: insights and treatment implications (Q38381463)

2 September 2017

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title

Genomics in acute lymphoblastic leukaemia: insights and treatment implications (English)

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2 September 2017

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2 September 2017

Kathryn G Roberts

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2 September 2017

language of work or name

English

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publication date

17 March 2015

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Nature Reviews Clinical Oncology

2 September 2017

published in

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2 September 2017

volume

12

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2 September 2017

issue

6

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2 September 2017

page(s)

344-357

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Acute lymphoblastic leukaemia

2 September 2017

cites work

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Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

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High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

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Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations

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A new prognostic score for CLL.

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Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

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Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.

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Clinical, immunophenotypic, cytogenetic, and molecular genetic features in 117 adult patients with mixed-phenotype acute leukemia defined by WHO-2008 classification

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

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Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting.

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Promoter DNA methylation pattern identifies prognostic subgroups in childhood T-cell acute lymphoblastic leukemia

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Methylation of tumour suppressor gene promoters in the presence and absence of transcriptional silencing in high hyperdiploid acute lymphoblastic leukaemia.

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Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia.

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Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options

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Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia

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DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.

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Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

21 January 2018

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Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

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c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

21 January 2018

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Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

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Progressive myoclonic ataxia associated with coeliac disease. The myoclonus is of cortical origin, but the pathology is in the cerebellum

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Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia

21 January 2018

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Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

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Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia

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Identifying driver mutations in sequenced cancer genomes: computational approaches to enable precision medicine

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Mutational heterogeneity in cancer and the search for new cancer-associated genes

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The Cancer Genome Atlas Pan-Cancer analysis project

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Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

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Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations

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Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse

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Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia

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ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence

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Identification of TP53 as an acute lymphocytic leukemia susceptibility gene through exome sequencing

21 January 2018

1 reference

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Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: rare clinical curios or potent genetic drivers?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults

21 January 2018

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https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Biology, risk stratification, and therapy of pediatric acute leukemias: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Minimal residual disease monitoring in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Impact of IKZF1 deletions on IKZF1 expression and outcome in Philadelphia chromosome negative childhood BCP-ALL. Reply to "incidence and biological significance of IKZF1/Ikaros gene deletions in pediatric Philadelphia chromosome negative and Philade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

What is the relevance of Ikaros gene deletions as a prognostic marker in pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Relapsed childhood acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Highly sensitive MRD tests for ALL based on the IKZF1 Δ3-6 microdeletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Screening for gene mutations: will identification of NT5C2 mutations help predict the chance of relapse in acute lymphoblastic leukemia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Analysis of TP53 mutations in relapsed childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Acute Lymphoblastic Leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

High Expression Levels of theETS-Related Gene,ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Reassessment of the prognostic significance of hypodiploidy in pediatric patients with acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Cancer genomes: discerning drivers from passengers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Exon 5 mutations in the p53 gene in relapsed childhood acute lymphoblastic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRCLINONC.2015.38

Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia

31 March 2020

1 reference

12 December 2020

Where do we stand in the treatment of relapsed acute lymphoblastic leukemia?

1 reference

12 December 2020

Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.

1 reference

12 December 2020

p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation.

1 reference

12 December 2020

Hypodiploidy is associated with a poor prognosis in childhood acute lymphoblastic leukemia.

1 reference

12 December 2020

Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line

1 reference

12 December 2020

Inherited susceptibility to pre B-ALL caused by germline transmission of PAX5 c.547G>A.

1 reference

12 December 2020

10.1038/NRCLINONC.2015.38

Identifiers

DOI

1 reference

2 September 2017

1 reference