Leptin signaling as a therapeutic target of obesity (Q38366277)

2 September 2017

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title

Leptin signaling as a therapeutic target of obesity (English)

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2 September 2017

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María J Moreno-Aliaga

4

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Carlos J González-Navarro

2 September 2017

object named as

Carlos J González-Navarro

2

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author name string

Neira Sáinz

1

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2 September 2017

J Alfredo Martínez

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2 September 2017

language of work or name

English

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publication date

1 March 2015

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Expert Opinion on Therapeutic Targets

2 September 2017

published in

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2 September 2017

volume

19

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2 September 2017

issue

7

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2 September 2017

page(s)

893-909

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Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism

2 September 2017

cites work

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Identification and expression cloning of a leptin receptor, OB-R

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Leptin and its receptors

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Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes.

21 January 2018

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Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

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Leptin receptor signaling and the regulation of mammalian physiology

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AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

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Role of obesity-associated dysfunctional adipose tissue in cancer: a molecular nutrition approach

21 January 2018

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Effects of the obese gene product on body weight regulation in ob/ob mice

21 January 2018

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

21 January 2018

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LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin

21 January 2018

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Intracellular signalling. Key enzyme in leptin-induced anorexia

21 January 2018

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Leptin at the intersection of neuroendocrinology and metabolism: current evidence and therapeutic perspectives.

21 January 2018

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In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin

21 January 2018

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Interactions between leptin and NPY affecting lipid mobilization in adipose tissue

21 January 2018

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Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms

21 January 2018

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Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes

21 January 2018

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Skeletal muscle AMP-activated protein kinase phosphorylation parallels metabolic phenotype in leptin transgenic mice under dietary modification

21 January 2018

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Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism

21 January 2018

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Leptin reduces the expression and increases the phosphorylation of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4 in muscle of ob/ob mice

21 January 2018

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Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin

21 January 2018

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Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Growth hormone regulates leptin gene expression in bovine adipose tissue: correlation with adipose IGF-1 expression

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Thyroid Hormones Influence Serum Leptin Concentrations in the Rat

21 January 2018

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Ghrelin and adipose tissue regulatory peptides: effect of gastric bypass surgery in obese humans

21 January 2018

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Galanin inhibits leptin expression and secretion in rat adipose tissue and 3T3-L1 adipocytes

21 January 2018

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Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice

21 January 2018

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Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity

21 January 2018

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Transcriptional regulation of the leptin promoter by insulin-stimulated glucose metabolism in 3t3-l1 adipocytes

21 January 2018

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Sp1-mediated transcription is involved in the induction of leptin by insulin-stimulated glucose metabolism.

21 January 2018

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Glucose enhances leptin signaling through modulation of AMPK activity

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

A nutrient-sensing pathway regulates leptin gene expression in muscle and fat.

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Triglycerides induce leptin resistance at the blood-brain barrier

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Effects of arachidonic acid on leptin secretion and expression in primary cultured rat adipocytes

21 January 2018

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Conjugated linoleic acid inhibits glucose metabolism, leptin and adiponectin secretion in primary cultured rat adipocytes.

21 January 2018

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Linoleic acid decreases leptin and adiponectin secretion from primary rat adipocytes in the presence of insulin.

21 January 2018

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Regulation of adipokine secretion by n-3 fatty acids.

21 January 2018

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Does omega-3 fatty acids supplementation affect circulating leptin levels? A systematic review and meta-analysis on randomized controlled clinical trials.

21 January 2018

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Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats.

21 January 2018

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The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation

21 January 2018

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Eicosapentaenoic fatty acid increases leptin secretion from primary cultured rat adipocytes: role of glucose metabolism

21 January 2018

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Omega-3 fatty acids: a review of the effects on adiponectin and leptin and potential implications for obesity management

21 January 2018

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Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss

21 January 2018

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1,25-Dihydroxyvitamin D3 upregulates leptin expression in mouse adipose tissue

21 January 2018

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Retinoic acid and vitamin D(3) powerfully inhibit in vitro leptin secretion by human adipose tissue

21 January 2018

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Inorganic phosphate as a signaling molecule: a potential strategy in osteosarcoma treatment.

21 January 2018

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Potential health concerns of dietary phosphorus: cancer, obesity, and hypertension

21 January 2018

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Lipoic acid inhibits leptin secretion and Sp1 activity in adipocytes

21 January 2018

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α-lipoic acid reduces fatty acid esterification and lipogenesis in adipocytes from overweight/obese subjects.

21 January 2018

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Multi-functional roles of chitosan as a potential protective agent against obesity

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Abnormal regulation of the leptin gene in the pathogenesis of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Challenges and opportunities of defining clinical leptin resistance

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Leptin resistance is associated with hypothalamic leptin receptor mRNA and protein downregulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Hyperleptinemia is associated with parameters of low-grade systemic inflammation and metabolic dysfunction in obese human beings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

C-reactive protein increases BBB permeability: implications for obesity and neuroinflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

High-fat diet induces site-specific unresponsiveness to LPS-stimulated STAT3 activation in the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Lentiviral vector-mediated knockdown of SOCS3 in the hypothalamus protects against the development of diet-induced obesity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

High-fat diet induces leptin resistance in leptin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Hyperleptinemia is required for the development of leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

The relation between dietary fructose, dietary fat and leptin responsiveness in rats

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding

21 January 2018

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Responses of gut microbiota to diet composition and weight loss in lean and obese mice

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

The gut microbiota reduces leptin sensitivity and the expression of the obesity-suppressing neuropeptides proglucagon (Gcg) and brain-derived neurotrophic factor (Bdnf) in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Leptin acts independently of food intake to modulate gut microbial composition in male mice

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

A leptin missense mutation associated with hypogonadism and morbid obesity.

21 January 2018

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A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient.

21 January 2018

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A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness

21 January 2018

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20 years of leptin: human disorders of leptin action

21 January 2018

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Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

21 January 2018

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Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

21 January 2018

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Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy

21 January 2018

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Leptin regulates striatal regions and human eating behavior

21 January 2018

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Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Fat and energy partitioning: longitudinal observations in leptin-treated adults homozygous for a Lep mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Leptin replacement alters brain response to food cues in genetically leptin-deficient adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Effects of leptin deficiency and replacement on cerebellar response to food-related cues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Long-term stabilization effects of leptin on brain functions in a leptin-deficient patient

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Leptin therapy in a congenital leptin-deficient patient leads to acute and long-term changes in homeostatic, reward, and food-related brain areas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Rapid improvement of hepatic steatosis after initiation of leptin substitution in a leptin-deficient girl

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Leptin substitution results in the induction of menstrual cycles in an adolescent with leptin deficiency and hypogonadotropic hypogonadism.

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

The effect of pegylated human recombinant leptin (PEG-OB) on neuroendocrine adaptations to semi-starvation in overweight men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Effects of very low calorie diet induced body weight loss with or without human pegylated recombinant leptin treatment on changes in ghrelin and adiponectin concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Long-Term Persistence of Hormonal Adaptations to Weight Loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Leptin reverses declines in satiation in weight-reduced obese humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

The decline in plasma leptin in response to calorie restriction predicts the effects of adjunctive leptin treatment on body weight in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Leptin administration does not prevent the bone mineral metabolism changes induced by weight loss

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Randomized double-blind placebo-controlled study of leptin administration after gastric bypass

21 January 2018

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20 years of leptin: leptin at 20: an overview

21 January 2018

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Partial leptin deficiency and human adiposity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Leptin treatment: facts and expectations.

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Central inflammation and leptin resistance are attenuated by ginsenoside Rb1 treatment in obese mice fed a high-fat diet

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Eicosapentaenoic acid inhibits tumour necrosis factor-α-induced lipolysis in murine cultured adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Pro-resolving lipid mediators are leads for resolution physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese‐diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.2015.1018824

Is obesity a disease of the blood-brain barrier? Physiological, pathological, and evolutionary considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728222.2015.1018824

Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity

21 January 2018

1 reference

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10.1517/14728222.2015.1018824

21 January 2018

Identifiers

DOI

1 reference

2 September 2017

1 reference