Extra-thymically induced T regulatory cell subsets: the optimal target for antigen-specific immunotherapy. (Q38365254)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25716063 AND SRC:MED&resulttype=core&format=json

1 March 2020

review article

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title

Extra-thymically induced T regulatory cell subsets: the optimal target for antigen-specific immunotherapy (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25716063 AND SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

1

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1 March 2020

Anja Wegner

series ordinal

2

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1 March 2020

author name string

David C Wraith

series ordinal

3

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1 March 2020

publication date

1 June 2015

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1 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25716063 AND SRC:MED&resulttype=core&format=json

1 March 2020

volume

145

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1 March 2020

issue

2

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1 March 2020

page(s)

171-181

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Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

1 March 2020

cites work

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Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy.

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Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3 T regulatory cells

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Comment on "Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3 T regulatory cells".

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Helios expression is a marker of T cell activation and proliferation.

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Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

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Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3 T reg cells

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Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora

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Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells

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Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism

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Ctla-4 modulates the differentiation of inducible Foxp3 Treg cells but IL-10 mediates their function in experimental autoimmune encephalomyelitis

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Natural and induced CD4 CD25 cells educate CD4 CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10.

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Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

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Interleukin-10 paradox: A potent immunoregulatory cytokine that has been difficult to harness for immunotherapy

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A CD4 T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

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Activation of human CD4 cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

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In vitro generation of interleukin 10-producing regulatory CD4( ) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

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Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3( ) regulatory T cells

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Retinoic acid increases Foxp3 regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression

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Retinoic acid can directly promote TGF-beta-mediated Foxp3( ) Treg cell conversion of naive T cells

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Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4 CD44hi Cells

21 January 2018

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Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor

21 January 2018

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An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells

21 January 2018

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Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3 CD4 regulatory T cells

21 January 2018

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PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

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The PDL1-PD1 Axis Converts Human T H 1 Cells into Regulatory T Cells

21 January 2018

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PD-1 regulates extrathymic regulatory T-cell differentiation

21 January 2018

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PD-1 is not required for natural or peripherally induced regulatory T cells: Severe autoimmunity despite normal production of regulatory T cells

21 January 2018

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Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease

21 January 2018

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Blockade of LFA-1 augments in vitro differentiation of antigen-induced Foxp3⁺ Treg cells

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Progranulin facilitates conversion and function of regulatory T cells under inflammatory conditions.

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Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells

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Infectious tolerance via the consumption of essential amino acids and mTOR signaling

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KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production

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Ex Vivo Expanded Autologous Polyclonal Regulatory T Cells Suppress Inhibitor Formation in Hemophilia.

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Ex vivo expanded human regulatory T cells delay islet allograft rejection via inhibiting islet-derived monocyte chemoattractant protein-1 production in CD34 stem cells-reconstituted NOD-scid IL2rγnull mice

21 January 2018

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Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3( ) regulatory T cells

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Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.

21 January 2018

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Type 1 regulatory T cells specific for collagen type II as an efficient cell-based therapy in arthritis

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Prevention of allogeneic cardiac graft rejection by transfer of ex vivo expanded antigen-specific regulatory T-cells

21 January 2018

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Prevention of CpG-induced pregnancy disruption by adoptive transfer of in vitro-induced regulatory T cells.

21 January 2018

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Mitigation of experimental allergic encephalomyelitis by TGF-beta induced Foxp3 regulatory T lymphocytes through the induction of anergy and infectious tolerance

21 January 2018

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TGF-beta-induced myelin peptide-specific regulatory T cells mediate antigen-specific suppression of induction of experimental autoimmune encephalomyelitis

21 January 2018

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Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

21 January 2018

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Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

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Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease

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Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells

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Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells

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Oral tolerance in the absence of naturally occurring Tregs

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STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.

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Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

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Antigenic strength controls the generation of antigen-specific IL-10-secreting T regulatory cells.

21 January 2018

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Distinct and complementary roles for Aspergillus fumigatus-specific Tr1 and Foxp3 regulatory T cells in humans and mice

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Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen

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Spatial map of human T cell compartmentalization and maintenance over decades of life

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Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs

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TGF-β-dependent induction of CD4 CD25 Foxp3 Tregs by liver sinusoidal endothelial cells

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Inducing and expanding regulatory T cell populations by foreign antigen

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IL-10 suppressor activity andex vivo Tr1 cell function are impaired in multiple sclerosis

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First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4 CD25 CD127- T regulatory cells

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Myelin-Reactive, TGF-β–Induced Regulatory T Cells Can Be Programmed To Develop Th1-Like Effector Function but Remain Less Proinflammatory Than Myelin-Reactive Th1 Effectors and Can Suppress Pathogenic T Cell Clonal Expansion In Vivo

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GILZ Promotes Production of Peripherally Induced Treg Cells and Mediates the Crosstalk between Glucocorticoids and TGF-β Signaling

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12 December 2020

In vivo-generated antigen-specific regulatory T cells treat autoimmunity without compromising antibacterial immune response

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Hypoxic culture conditions enhance the generation of regulatory T cells

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12 December 2020

Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection

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12 December 2020