Molecular basis of the high insecticidal potency of scorpion alpha-toxins (Q38341470)

2 September 2017

title

Molecular basis of the high insecticidal potency of scorpion alpha-toxins (English)

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2 September 2017

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Izhar Karbat

1

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2 September 2017

Felix Frolow

2

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2 September 2017

Oren Froy

3

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2 September 2017

Nicolas Gilles

4

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2 September 2017

Lior Cohen

5

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2 September 2017

Michael Turkov

6

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2 September 2017

Dalia Gordon

7

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2 September 2017

Michael Gurevitz

8

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2 September 2017

language of work or name

English

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publication date

8 May 2004

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

279

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2 September 2017

issue

30

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2 September 2017

page(s)

31679-31686

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From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

2 September 2017

cites work

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Binding of an alpha scorpion toxin to insect sodium channels is not dependent on membrane potential

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Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels

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delta-Atracotoxins from australian funnel-web spiders compete with scorpion alpha-toxin binding but differentially modulate alkaloid toxin activation of voltage-gated sodium channels

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Identification of structural elements of a scorpion alpha-neurotoxin important for receptor site recognition.

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Diversification of neurotoxins by C-tail 'wiggling': a scorpion recipe for survival

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Vectors for selective expression of cloned DNAs by T7 RNA polymerase

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Nucleotide sequence and structure analysis of a cDNA encoding an alpha insect toxin from the scorpion Leiurus quinquestriatus hebraeus

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Effect of depolarization on binding kinetics of scorpion alpha-toxin highlights conformational changes of rat brain sodium channels

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Structural implications on the interaction of scorpion alpha-like toxins with the sodium channel receptor site inferred from toxin iodination and pH-dependent binding.

21 January 2018

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

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21 January 2018

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21 January 2018

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Refinement of macromolecular structures by the maximum-likelihood method

21 January 2018

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Checking your imagination: applications of the free R value

21 January 2018

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Automated refinement of protein models

21 January 2018

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21 January 2018

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Conformation of Polypeptides and Proteins

21 January 2018

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Solution structures of a highly insecticidal recombinant scorpion alpha-toxin and a mutant with increased activity

21 January 2018

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Crystal structure of toxin II from the scorpion Androctonus australis Hector refined at 1.3 A resolution

21 January 2018

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Crystal structures of two alpha-like scorpion toxins: non-proline cis peptide bonds and implications for new binding site selectivity on the sodium channel

21 January 2018

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Structure/activity relationships of scorpion alpha-toxins. Multiple residues contribute to the interaction with receptors

21 January 2018

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Use of antibodies specific to defined regions of scorpion alpha-toxin to study its interaction with its receptor site on the sodium channel

21 January 2018

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Orthorhombic crystals and three-dimensional structure of the potent toxin II from the scorpion Androctonus australis Hector

21 January 2018

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Non-proline cis peptide bonds in proteins.

21 January 2018

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Scorpion alpha-like toxins, toxic to both mammals and insects, differentially interact with receptor site 3 on voltage-gated sodium channels in mammals and insects.

21 January 2018

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Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes

21 January 2018

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The voltage-sensitive sodium channel is a bell-shaped molecule with several cavities

21 January 2018

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X-ray structure of a voltage-dependent K channel

21 January 2018

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Dissection of the functional surface of an anti-insect excitatory toxin illuminates a putative "hot spot" common to all scorpion beta-toxins affecting Na channels.

21 January 2018

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Conversion of a scorpion toxin agonist into an antagonist highlights an acidic residue involved in voltage sensor trapping during activation of neuronal Na channels

21 January 2018

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Scorpion toxins specific for Na -channels

21 January 2018

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NMR structures and activity of a novel alpha-like toxin from the scorpion Leiurus quinquestriatus hebraeus

21 January 2018

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Functional Anatomy of Scorpion Toxins Affecting Sodium Channels

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M402048200

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2 September 2017

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