A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. (Q38336587)

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1 January 2020

title

A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation (English)

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1 January 2020

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5

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author name string

Kenji Sugimoto

1

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1 January 2020

Mutsuhiro Ohata

2

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1 January 2020

Jun Miyoshi

3

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1 January 2020

Hiroyoshi Ishizaki

4

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1 January 2020

Akio Masuda

6

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1 January 2020

Yasunobu Yoshikai

7

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1 January 2020

Masaya Takamoto

8

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1 January 2020

Kazuo Sugane

9

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1 January 2020

Seiichi Matsuo

10

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1 January 2020

Yasuhiro Shimada

11

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1 January 2020

Tetsuya Matsuguchi

12

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1 January 2020

language of work or name

English

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publication date

1 September 2004

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Journal of Clinical Investigation

1 January 2020

published in

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volume

114

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issue

6

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1 January 2020

page(s)

857-866

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NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity

1 January 2020

cites work

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NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

6 September 2017

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6 September 2017

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Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

6 September 2017

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Mechanism and control of class-switch recombination

6 September 2017

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A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines

6 September 2017

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Regulation of IL-12 p40 promoter activity in primary human monocytes: roles of NF-kappaB, CCAAT/enhancer-binding protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2).

6 September 2017

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Toll-like receptors: critical proteins linking innate and acquired immunity

6 September 2017

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TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

6 September 2017

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Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages

6 September 2017

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Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

6 September 2017

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Mechanisms of phagocytosis in macrophages

6 September 2017

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Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice

6 September 2017

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The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases

6 September 2017

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TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105

6 September 2017

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CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

6 September 2017

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DNA and a CpG oligonucleotide derived from Babesia bovis are mitogenic for bovine B cells

6 September 2017

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Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis

6 September 2017

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Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase

6 September 2017

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Interleukin-10-deficient mice develop chronic enterocolitis

6 September 2017

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Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

6 September 2017

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Extent of T cell receptor ligation can determine the functional differentiation of naive CD4 T cells

6 September 2017

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The effect of antigen dose on CD4 T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model

6 September 2017

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Hamster cell line suitable for transfection assay of transforming genes

6 September 2017

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Structure and transforming potential of the human cot oncogene encoding a putative protein kinase

6 September 2017

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Lipopolysaccharide-induced tumor necrosis factor alpha production by human monocytes involves the raf-1/MEK1-MEK2/ERK1-ERK2 pathway

6 September 2017

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Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.

6 September 2017

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MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll‐like receptor 2 signaling

14 September 2017

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Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.

14 September 2017

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Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma

14 September 2017

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IRF3 mediates a TLR3/TLR4-specific antiviral gene program

14 September 2017

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Gene expressions of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes.

27 September 2017

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Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells

27 September 2017

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Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development

27 September 2017

1 reference

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Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation

27 September 2017

1 reference

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27 September 2017

Antibody class switching

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The density of the class II MHC T cell receptor ligand influences IFN-gamma/IL-4 ratios in immune responses in vivo.

27 September 2017

1 reference

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Critical role of protein kinase C epsilon for lipopolysaccharide-induced IL-12 synthesis in monocyte-derived dendritic cells

23 June 2018

1 reference

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Rapidly fatal leishmaniasis in resistant C57BL/6 mice lacking TNF.

31 August 2018

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Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha ) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts

31 August 2018

1 reference

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TNF receptor p55 is required for elimination of inflammatory cells following control of intracellular pathogens.

31 August 2018

1 reference

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K-ras is essential for the development of the mouse embryo

31 August 2018

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12 December 2020

The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation

1 reference

12 December 2020

Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB

1 reference

12 December 2020

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

12 December 2020

Genetically Resistant Mice Lacking MyD88-Adapter Protein Display a High Susceptibility to Leishmania major Infection Associated with a Polarized Th2 Response

1 reference

12 December 2020

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4 T cells

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12 December 2020

Identifiers

DOI

10.1172/JCI20014

1 reference

2 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15372110 AND SRC:MED&resulttype=core&format=json

release_6nqpvsxayfcohnte2weu2z5jem

1 January 2020

Fatcat ID

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Fatcat

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24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15372110 AND SRC:MED&resulttype=core&format=json

1 January 2020

PubMed publication ID

15372110

1 reference