Natural products as leads in schistosome drug discovery. (Q38334179)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25625682 AND SRC:MED&resulttype=core&format=json

28 February 2020

review article

1 reference

title

Natural products as leads in schistosome drug discovery (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25625682 AND SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25625682 AND SRC:MED&resulttype=core&format=json

28 February 2020

Carolina Horta Andrade

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25625682 AND SRC:MED&resulttype=core&format=json

28 February 2020

Pedro Cravo

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25625682 AND SRC:MED&resulttype=core&format=json

28 February 2020

author name string

Pedro V L Cravo

series ordinal

3

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PubMed publication ID

25625682

2 September 2017

language of work or name

English

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publication date

23 January 2015

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28 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25625682 AND SRC:MED&resulttype=core&format=json

28 February 2020

volume

20

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28 February 2020

issue

2

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28 February 2020

page(s)

1872-1903

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Creative Commons Attribution 4.0 International

28 February 2020

copyright license

start time

23 January 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Serotonin signaling in Schistosoma mansoni: a serotonin-activated G protein-coupled receptor controls parasite movement

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21 January 2018

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21 January 2018

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In vivo effect of single oral dose of artemether against early juvenile stages of Schistosoma mansoni Egyptian strain.

21 January 2018

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21 January 2018

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Artemether administered together with haemin damages schistosomes in vitro

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Schistosoma mansoni: the developmental regulation and immunolocalization of antioxidant enzymes.

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New uses for old drugs: the tale of artemisinin derivatives in the elimination of schistosomiasis japonica in China.

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Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: an open-label randomised controlled trial

21 January 2018

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Artesunate plus sulfadoxine/pyrimethamine versus praziquantel in the treatment of Schistosoma mansoni in eastern Sudan

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21 January 2018

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21 January 2018

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The genome of the blood fluke Schistosoma mansoni

21 January 2018

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The Schistosoma japonicum genome reveals features of host-parasite interplay

21 January 2018

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Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites

21 January 2018

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Characterization of the Phytochelatin Synthase of Schistosoma mansoni

21 January 2018

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Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni

21 January 2018

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Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets

21 January 2018

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Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components

21 January 2018

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A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase

21 January 2018

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21 January 2018

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Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target

21 January 2018

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21 January 2018

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21 January 2018

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A penta-substituted pyridine alkaloid from the rhizome of Jatropha elliptica (Pohl) Muell. Arg. is active against Schistosoma mansoni and Biomphalaria glabrata.

21 January 2018

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Antischistosomal activity of a calcium channel antagonist on schistosomula and adult Schistosoma mansoni worms

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Evaluation of the schistosomicidal activity of the steroidal alkaloids from Solanum lycocarpum fruits.

21 January 2018

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Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis

21 January 2018

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21 January 2018

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Antischistosomal activities of mefloquine-related arylmethanols

21 January 2018

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Antischistosomal bioactivity of isoflavonoids from Millettia thonningii (Leguminosae).

21 January 2018

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In vitro schistosomicidal activity of some brazilian cerrado species and their isolated compounds

21 January 2018

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Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD( ) catabolizing enzyme

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21 January 2018

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In vitro and in vivo effects of unsaturated fatty acids on Schistosoma mansoni and S. haematobium lung-stage larvae

21 January 2018

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Equilibrium in lung schistosomula sphingomyelin breakdown and biosynthesis allows very small molecules, but not antibody, to access proteins at the host-parasite interface.

21 January 2018

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21 January 2018

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Natural product isolation--how to get from biological material to pure compounds

21 January 2018

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In vitro and in vivo trematode models for chemotherapeutic studies

21 January 2018

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Schistosomes: challenges in compound screening

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Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening

21 January 2018

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Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases

21 January 2018

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Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis.

21 January 2018

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Automated imaging and other developments in whole-organism anthelmintic screening

21 January 2018

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Increasing the Content of High-Content Screening: An Overview

21 January 2018

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Segmenting the etiological agent of schistosomiasis for high-content screening

21 January 2018

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Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect schistosoma viability

21 January 2018

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Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation

21 January 2018

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3-oxoacyl-ACP reductase from Schistosoma japonicum: integrated in silico-in vitro strategy for discovering antischistosomal lead compounds

21 January 2018

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Aldose reductase from Schistosoma japonicum: crystallization and structure-based inhibitor screening for discovering antischistosomal lead compounds

21 January 2018

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Discovery of new inhibitors of Schistosoma mansoni PNP by pharmacophore-based virtual screening.

21 January 2018

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Assessing the performance of 3D pharmacophore models in virtual screening: how good are they?

21 January 2018

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Development of a natural products database from the biodiversity of Brazil.

21 January 2018

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SuperNatural: a searchable database of available natural compounds

21 January 2018

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Seaweed metabolite database (SWMD): A database of natural compounds from marine algae

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Virtual screening methods as tools for drug lead discovery from large chemical libraries

21 January 2018

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Virtual screening strategies in medicinal chemistry: the state of the art and current challenges.

21 January 2018

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Databases aim to bridge the East-West divide of drug discovery.

21 January 2018

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TCM Database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico

21 January 2018

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HIT: linking herbal active ingredients to targets

21 January 2018

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NPACT: Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target database

21 January 2018

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TMDB: a literature-curated database for small molecular compounds found from tea.

21 January 2018

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MAPS Database: Medicinal plant Activities, Phytochemical and Structural Database

21 January 2018

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TIPdb: a database of anticancer, antiplatelet, and antituberculosis phytochemicals from indigenous plants in Taiwan.

21 January 2018

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TIPdb-3D: the three-dimensional structure database of phytochemicals from Taiwan indigenous plants

21 January 2018

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Glossary of terms used in medicinal chemistry (IUPAC Recommendations 1998)

21 January 2018

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Pharmacophore modeling and three dimensional database searching for drug design using catalyst: recent advances

21 January 2018

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GALAHAD: 1. pharmacophore identification by hypermolecular alignment of ligands in 3D.

21 January 2018

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Identification of common functional configurations among molecules

21 January 2018

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PHASE: a new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results

21 January 2018

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QSAR modeling: where have you been? Where are you going to?

21 January 2018

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3D-QSAR approaches in drug design: perspectives to generate reliable CoMFA models

21 January 2018

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Discovery of new potential hits of Plasmodium falciparum enoyl-ACP reductase through ligand- and structure-based drug design approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Structural and chemical basis for enhanced affinity to a series of mycobacterial thymidine monophosphate kinase inhibitors: fragment-based QSAR and QM/MM docking studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Best Practices for QSAR Model Development, Validation, and Exploitation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Discovery of novel antimalarial compounds enabled by QSAR-based virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

On the use of the metric rm² as an effective tool for validation of QSAR models in computational drug design and predictive toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

On the development and validation of QSAR models

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Real External Predictivity of QSAR Models: How To Evaluate It? Comparison of Different Validation Criteria and Proposal of Using the Concordance Correlation Coefficient

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Real external predictivity of QSAR models. Part 2. New intercomparable thresholds for different validation criteria and the need for scatter plot inspection

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Virtual ligand screening: strategies, perspectives and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Structure-based virtual screening for drug discovery: principles, applications and recent advances.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

FRED pose prediction and virtual screening accuracy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

FRED and HYBRID docking performance on standardized datasets

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Structure-based virtual screening approach for discovery of covalently bound ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

FlexX-Scan: fast, structure-based virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Improved protein-ligand docking using GOLD

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Protein Flexibility and Ligand Recognition: Challenges for Molecular Modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Optimization of compound ranking for structure-based virtual ligand screening using an established FRED-Surflex consensus approach

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Consensus scoring approach to identify the inhibitors of AMP-activated protein kinase α2 with virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Consensus scoring for protein-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

High-throughput structure-based pharmacophore modelling as a basis for successful parallel virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Pharmacophore modelling: a forty year old approach and its modern synergies

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Inverse Virtual Screening allows the discovery of the biological activity of natural compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Inverse virtual screening of antitumor targets: pilot study on a small database of natural bioactive compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Facing the challenges of structure-based target prediction by inverse virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Modern Natural Products Chemistry and Drug Discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

ALTERAÇÕES TEGUMENTARES EM DUAS DIFERENTES LINHAGENS DE Schistosoma mansoni SUBMETIDAS A TRATAMENTO COM ARTEMISININA E ÁCIDO ARTESÚNICO

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES20021872

Effects of goyazensolide during in vitro cultivation of Schistosoma mansoni

21 January 2018

1 reference

12 December 2020

Effect of artemether against Schistosoma haematobium in experimentally infected hamsters

1 reference

12 December 2020

pKa based protonation states and microspecies for protein–ligand docking

1 reference

12 December 2020

Laboratory induced resistance to praziquantel in experimental schistosomiasis

1 reference

12 December 2020

Schistosoma japonicum: In vitro effects of artemether combined with haemin depend on cultivation media and appraisal of artemether products appearing in the media

1 reference

12 December 2020

Short report: diminished susceptibility to praziquantel in a Senegal isolate of Schistosoma mansoni.

1 reference

12 December 2020

Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections

1 reference

12 December 2020

Development of a defined medium for arachidonic acid production by Mortierella alpina using a visualization method

1 reference

12 December 2020

Enzymatic hydrolysis and extraction of arachidonic acid rich lipids from Mortierella alpina

1 reference

12 December 2020

Antimicrobial substances of superior plants. XXVII. Isolation of plumbagin from Plumbago scandens L

1 reference

12 December 2020

African Ethnobotany and Healthcare: Emphasis on Mozambique

1 reference

12 December 2020

Rule-Based Classification of Chemical Structures by Scaffold

1 reference

12 December 2020

A comparative study of the reproductive system of mature, immature and "unisexual" female Schistosoma mansoni.

1 reference

12 December 2020

Phytochemical informatics of traditional Chinese medicine and therapeutic relevance

1 reference

12 December 2020

Schistosomicidal evaluation of flavonoids from two species of Styrax against Schistosoma mansoni adult worms

1 reference

12 December 2020

Comparative studies on some metrics for external validation of QSPR models

1 reference

12 December 2020

Evaluation of dihydroisocoumarins produced by the endophytic fungus Arthrinium state of Apiospora montagnei against Schistosoma mansoni

1 reference

12 December 2020

Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails

1 reference

12 December 2020

Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel.

1 reference

12 December 2020

Current strategies for drug discovery through natural products

1 reference

12 December 2020

Fungal transformation and schistosomicidal effects of pimaradienoic acid

1 reference

12 December 2020

[Ivermectin, a broad spectrum antiparasitic drug].

1 reference

12 December 2020

The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part II.

1 reference

12 December 2020

Protein kinases as potential targets for novel anti-schistosomal strategies.

1 reference

12 December 2020

Effect of artemether on the tegument of adult Schistosoma haematobium recovered from mice

1 reference

12 December 2020

Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific.

1 reference

12 December 2020

Repurposing drugs for the treatment and control of helminth infections

1 reference

12 December 2020

10.3390/MOLECULES20021872

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25625682 AND SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25625682 AND SRC:MED&resulttype=core&format=json

28 February 2020

PubMed publication ID

25625682

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25625682 AND SRC:MED&resulttype=core&format=json