Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis (Q38326581)

2 September 2017

7 references

13 March 2019

17 June 2019

30 June 2019

28 September 2019

6 October 2019

11 October 2019

18 November 2019

Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis (English)

1 reference

human musculoskeletal system

2 September 2017

0 references

7 references

13 March 2019

17 June 2019

30 June 2019

28 September 2019

6 October 2019

11 October 2019

18 November 2019

7 references

13 March 2019

17 June 2019

30 June 2019

28 September 2019

6 October 2019

11 October 2019

18 November 2019

1 reference

28 September 2019

1 reference

6 October 2019

1 reference

11 October 2019

1 reference

18 November 2019

Carolyn M Dancevic

1

1 reference

2 September 2017

Daniel R McCulloch

series ordinal

2

1 reference

2 September 2017

language of work or name

1 reference

1 January 2014

1 reference

Arthritis Research and Therapy

2 September 2017

8 references

2 September 2017

13 March 2019

17 June 2019

30 June 2019

28 September 2019

6 October 2019

11 October 2019

18 November 2019

16

1 reference

2 September 2017

5

1 reference

2 September 2017

429

1 reference

Creative Commons Attribution

2 September 2017

7 references

13 March 2019

17 June 2019

30 June 2019

28 September 2019

6 October 2019

11 October 2019

18 November 2019

0 references

on focus list of Wikimedia project

ScienceSource

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27 September 2017

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27 September 2017

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23 June 2018

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23 June 2018

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23 June 2018

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31 August 2018

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31 August 2018

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31 August 2018

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31 August 2018

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Development of a novel immunoassay for the measurement of type II collagen neoepitope generated by collagenase cleavage

31 August 2018

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Interleukin‐6 upregulates expression of ADAMTS‐4 in fibroblast‐like synoviocytes from patients with rheumatoid arthritis

31 August 2018

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Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors

31 August 2018

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31 August 2018

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31 August 2018

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31 August 2018

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31 August 2018

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Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: a relationship among efficacy, joint toxicity and anticonvulsant status

31 August 2018

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31 August 2018

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31 August 2018

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31 August 2018

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A randomized phase II feasibility trial of BMS-275291 in patients with early stage breast cancer

31 August 2018

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31 August 2018

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A randomized phase II pilot trial of adjuvant marimastat in patients with early-stage breast cancer

31 August 2018

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Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors

31 August 2018

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Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. European Leflunomide Study Group

31 August 2018

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Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.

31 August 2018

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Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide.

31 August 2018

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Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines

31 August 2018

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Inhibitory effects of simvastatin on migration and invasion of rheumatoid fibroblast-like synoviocytes by preventing geranylgeranylation of RhoA

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Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5–hyaluronan complexes in articular cartilages

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Degradation of type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explant cultures

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TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)

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ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo

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A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts

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Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice

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12 December 2020

Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor

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12 December 2020

Effect of Atorvastatin on Inflammation and Modification of Vascular Risk Factors in Rheumatoid Arthritis

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12 December 2020

Structure-activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors

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Distribution of aggrecanase (ADAMts 4/5) cleavage products in normal and osteoarthritic human articular cartilage: the influence of age, topography and zone of tissue

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Identifiers

DOI

1 reference

Dimensions Publication ID

2 September 2017

0 references

1 reference

2 September 2017

PubMed publication ID

25606593

1 reference