Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells. (Q38318487)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10559252 AND SRC:MED&resulttype=core&format=json

1 November 2019

title

Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells (English)

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1 November 2019

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2

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1 November 2019

author name string

M J Calonge

series ordinal

1

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1 November 2019

language of work or name

English

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publication date

1 November 1999

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Journal of Biological Chemistry

1 November 2019

published in

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1 November 2019

volume

274

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1 November 2019

issue

47

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1 November 2019

page(s)

33637-33643

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Lessons from hereditary colorectal cancer

1 November 2019

cites work

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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

21 January 2018

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Transfection of the type II TGF-beta receptor into colon cancer cells increases receptor expression, inhibits cell growth, and reduces the malignant phenotype

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DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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Mutations in the SMAD4/DPC4 gene in juvenile polyposis

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Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

21 January 2018

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The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

21 January 2018

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MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

21 January 2018

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Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

21 January 2018

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A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

21 January 2018

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Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer

21 January 2018

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Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

21 January 2018

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Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

21 January 2018

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FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals

21 January 2018

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Genomic sequencing of DPC4 in the analysis of familial pancreatic carcinoma

21 January 2018

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Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase

21 January 2018

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

21 January 2018

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MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

21 January 2018

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Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer

21 January 2018

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

21 January 2018

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Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

21 January 2018

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Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex.

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A transcriptional partner for MAD proteins in TGF-beta signalling

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Smad4 and FAST-1 in the assembly of activin-responsive factor

21 January 2018

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Evidence for c-myc in the signaling pathway for TGF-beta in well-differentiated human colon carcinoma cells

21 January 2018

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Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

21 January 2018

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Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect

21 January 2018

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Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma

21 January 2018

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Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

21 January 2018

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Cell cycle targets of Ras/Raf signalling

21 January 2018

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Prevalence of ras gene mutations in human colorectal cancers

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.47.33637

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10559252 AND SRC:MED&resulttype=core&format=json

1 November 2019

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