Emerging roles of tRNA in adaptive translation, signalling dynamics and disease (Q38298151)

1 September 2017

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title

Emerging roles of tRNA in adaptive translation, signalling dynamics and disease (English)

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1 September 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25534324 AND SRC:MED&resulttype=core&format=json

12 June 2020

Zoya Ignatova

2

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publication date

23 December 2014

1 reference

1 September 2017

published in

Nature Reviews Genetics

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25534324 AND SRC:MED&resulttype=core&format=json

12 June 2020

volume

16

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25534324 AND SRC:MED&resulttype=core&format=json

12 June 2020

issue

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25534324 AND SRC:MED&resulttype=core&format=json

12 June 2020

page(s)

98-112

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25534324 AND SRC:MED&resulttype=core&format=json

The ribosome as a molecular machine: the mechanism of tRNA–mRNA movement in translocation

12 June 2020

cites work

1 reference

Toward a more complete view of tRNA biology

21 January 2018

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Slicing tRNAs to boost functional ncRNA diversity

21 January 2018

1 reference

Transfer RNA and human disease

21 January 2018

1 reference

Role of RNA methyltransferases in tissue renewal and pathology

21 January 2018

1 reference

Human mitochondrial DNA: roles of inherited and somatic mutations

21 January 2018

1 reference

Human mitochondrial tRNAs: biogenesis, function, structural aspects, and diseases

21 January 2018

1 reference

Aminoacyl-tRNA synthetases in medicine and disease

21 January 2018

1 reference

tRNA modifications: Necessary for correct tRNA-derived fragments during the recovery from stress?

21 January 2018

1 reference

Biosynthesis and function of posttranscriptional modifications of transfer RNAs

21 January 2018

1 reference

tRNA's modifications bring order to gene expression

21 January 2018

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tRNA biology charges to the front

21 January 2018

1 reference

21 January 2018

Aminoacyl-tRNA synthesis

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Ribosome structure and the mechanism of translation

21 January 2018

1 reference

Mitochondrial Genome Evolution and the Origin of Eukaryotes

21 January 2018

1 reference

Natural expansion of the genetic code

21 January 2018

1 reference

GtRNAdb: a database of transfer RNA genes detected in genomic sequence

21 January 2018

1 reference

tRNA gene copy number variation in humans.

21 January 2018

1 reference

Diversity of human tRNA genes from the 1000-genomes project

21 January 2018

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Diversity of tRNA genes in eukaryotes

21 January 2018

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Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes.

21 January 2018

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Nucleolar clustering of dispersed tRNA genes.

21 January 2018

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Co-variation of tRNA abundance and codon usage in Escherichia coli at different growth rates.

21 January 2018

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Different sequence signatures in the upstream regions of plant and animal tRNA genes shape distinct modes of regulation

21 January 2018

1 reference

TATA-Binding protein-TATA interaction is a key determinant of differential transcription of silkworm constitutive and silk gland-specific tRNA(Ala) genes

21 January 2018

1 reference

How the sequence of a gene can tune its translation

21 January 2018

1 reference

Folding at the birth of the nascent chain: coordinating translation with co-translational folding

21 January 2018

1 reference

Understanding the contribution of synonymous mutations to human disease

21 January 2018

1 reference

Non-optimal codon usage affects expression, structure and function of clock protein FRQ

21 January 2018

1 reference

Speeding with control: codon usage, tRNAs, and ribosomes

21 January 2018

1 reference

Synonymous but not the same: the causes and consequences of codon bias

21 January 2018

1 reference

A role for tRNA modifications in genome structure and codon usage

21 January 2018

1 reference

Tissue-specific differences in human transfer RNA expression

21 January 2018

1 reference

A dual program for translation regulation in cellular proliferation and differentiation

21 January 2018

1 reference

Tissue-specific codon usage and the expression of human genes

21 January 2018

1 reference

Rare codons regulate KRas oncogenesis

21 January 2018

1 reference

Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes.

21 January 2018

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Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors

21 January 2018

1 reference

A sequence element that tunes Escherichia coli tRNA(Ala)(GGC) to ensure accurate decoding.

21 January 2018

1 reference

Evolutionary optimization of speed and accuracy of decoding on the ribosome

21 January 2018

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tRNA concentration fine tunes protein solubility.

21 January 2018

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A comprehensive tRNA deletion library unravels the genetic architecture of the tRNA pool

21 January 2018

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tRNA genes rapidly change in evolution to meet novel translational demands.

21 January 2018

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Functional analysis of human tRNA isodecoders

21 January 2018

1 reference

Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor

21 January 2018

1 reference

Abundance of tRNA-derived small RNAs in phosphate-starved Arabidopsis roots

21 January 2018

1 reference

Small ncRNA transcriptome analysis from Aspergillus fumigatus suggests a novel mechanism for regulation of protein synthesis

21 January 2018

1 reference

tRNA cleavage is a conserved response to oxidative stress in eukaryotes

21 January 2018

1 reference

Identification and functional characterization of tRNA-derived RNA fragments (tRFs) in respiratory syncytial virus infection

21 January 2018

1 reference

The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae

21 January 2018

1 reference

Angiogenin cleaves tRNA and promotes stress-induced translational repression

21 January 2018

1 reference

Genome-wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress

21 January 2018

1 reference

Reversible and rapid transfer-RNA deactivation as a mechanism of translational repression in stress.

21 January 2018

1 reference

Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly

21 January 2018

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Angiogenin-induced tRNA fragments inhibit translation initiation

21 January 2018

1 reference

Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection

21 January 2018

1 reference

The RNA methyltransferase Dnmt2 is required for efficient Dicer-2-dependent siRNA pathway activity in Drosophila

21 January 2018

1 reference

5' tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction

21 January 2018

1 reference

Translational control in stress and apoptosis

21 January 2018

1 reference

The eIF2α kinases: their structures and functions

21 January 2018

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Rapid and reversible nuclear accumulation of cytoplasmic tRNA in response to nutrient availability

21 January 2018

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New functions of protein kinase Gcn2 in yeast and mammals.

21 January 2018

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Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

21 January 2018

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A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress

21 January 2018

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Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

21 January 2018

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Loss of a conserved tRNA anticodon modification perturbs cellular signaling

21 January 2018

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Eukaryotic wobble uridine modifications promote a functionally redundant decoding system.

21 January 2018

1 reference

Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants

21 January 2018

1 reference

Ribosome profiling: new views of translation, from single codons to genome scale

21 January 2018

1 reference

Candida albicans CUG mistranslation is a mechanism to create cell surface variation.

21 January 2018

1 reference

Misacylation of tRNA with methionine in Saccharomyces cerevisiae

21 January 2018

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Innate immune and chemically triggered oxidative stress modifies translational fidelity.

21 January 2018

1 reference

Misacylation of specific nonmethionyl tRNAs by a bacterial methionyl-tRNA synthetase

21 January 2018

1 reference

Adaptive antioxidant methionine accumulation in respiratory chain complexes explains the use of a deviant genetic code in mitochondria

21 January 2018

1 reference

Mitochondrial tRNA import and its consequences for mitochondrial translation

21 January 2018

1 reference

MITOMAP: a human mitochondrial genome database--2004 update

21 January 2018

1 reference

Pathophysiology of the MELAS 3243 Transition Mutation

21 January 2018

1 reference

Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases

21 January 2018

1 reference

Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease

21 January 2018

1 reference

Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease

21 January 2018

1 reference

Hypocitrullinemia in patients with MELAS: an insight into the "MELAS paradox".

21 January 2018

1 reference

Maternally inherited essential hypertension is associated with the novel 4263A>G mutation in the mitochondrial tRNAIle gene in a large Han Chinese family.

21 January 2018

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Hypertension as a mitochondrial and metabolic disease

21 January 2018

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Mitochondrial transfer RNAMet 4435A>G mutation is associated with maternally inherited hypertension in a Chinese pedigree

21 January 2018

1 reference

RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration.

21 January 2018

1 reference

Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function

21 January 2018

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CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration

21 January 2018

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CLP1 links tRNA metabolism to progressive motor-neuron loss

21 January 2018

1 reference

A major determinant for binding and aminoacylation of tRNA(Ala) in cytoplasmic Alanyl-tRNA synthetase is mutated in dominant axonal Charcot-Marie-Tooth disease

21 January 2018

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Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma

21 January 2018

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Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration

21 January 2018

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Neuromuscular junction maturation defects precede impaired lower motor neuron connectivity in Charcot-Marie-Tooth type 2D mice

21 January 2018

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Central nervous system manifestations of mitochondrial disorders

21 January 2018

1 reference

Mutation in ADAT3, encoding adenosine deaminase acting on transfer RNA, causes intellectual disability and strabismus.

21 January 2018

1 reference

Whole exome sequencing identifies a splicing mutation in NSUN2 as a cause of a Dubowitz-like syndrome

21 January 2018

1 reference

Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer

21 January 2018

1 reference

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

21 January 2018

1 reference

Defects in translational regulation contributing to human cognitive and behavioral disease

21 January 2018

1 reference

Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice

21 January 2018

1 reference

Identification of a splicing variant that regulates type 2 diabetes risk factor CDKAL1 level by a coding-independent mechanism in human

21 January 2018

1 reference

Functional loss of Cdkal1, a novel tRNA modification enzyme, causes the development of type 2 diabetes [Review]

21 January 2018

1 reference

The cancerous translation apparatus

21 January 2018

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RNA polymerase III transcription and cancer

21 January 2018

1 reference

tRNA over-expression in breast cancer and functional consequences

21 January 2018

1 reference

High levels of tRNA abundance and alteration of tRNA charging by bortezomib in multiple myeloma

21 January 2018

1 reference

Depletion of cognate charged transfer RNA causes translational frameshifting within the expanded CAG stretch in huntingtin

21 January 2018

1 reference

Huntington's disease gene: regional and cellular expression in brain of normal and affected individuals

21 January 2018

1 reference

A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux

21 January 2018

1 reference

A guide to genome engineering with programmable nucleases

21 January 2018

1 reference

Systematic identification of tRNAome and its dynamics in Lactococcus lactis

21 January 2018

1 reference

Do all modifications benefit all tRNAs?

21 January 2018

1 reference

A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs

21 January 2018

1 reference

MODOMICS: a database of RNA modification pathways. 2008 update

21 January 2018

1 reference

The gene for a tRNA modifying enzyme, m5U54-methyltransferase, is essential for viability in Escherichia coli

21 January 2018

1 reference

The RNA binding protein Hfq interacts specifically with tRNAs.

21 January 2018

1 reference

Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen

21 January 2018

1 reference

RNA-dependent lipid remodeling by bacterial multiple peptide resistance factors

21 January 2018

1 reference

Glutamyl-transfer RNA: a precursor of heme and chlorophyll biosynthesis.

21 January 2018

1 reference

Arginylation of beta-actin regulates actin cytoskeleton and cell motility

21 January 2018

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Regulation of cell death by transfer RNA

21 January 2018

1 reference

Human tRNA genes function as chromatin insulators

21 January 2018

1 reference

A structure-based mechanism for tRNA and retroviral RNA remodelling during primer annealing

21 January 2018

1 reference

Small noncoding RNAs in cells transformed by human T-cell leukemia virus type 1: a role for a tRNA fragment as a primer for reverse transcriptase

21 January 2018

1 reference

From one amino acid to another: tRNA-dependent amino acid biosynthesis

21 January 2018

1 reference

Discovering RNA-protein interactome by using chemical context profiling of the RNA-protein interface

21 January 2018

1 reference

Misfolded human tRNA isodecoder binds and neutralizes a 3′ UTR-embedded Alu element

21 January 2018

1 reference

Proofreading and aminoacylation of tRNAs before export from the nucleus

21 January 2018

1 reference

Functional consequences of mitochondrial tRNA Trp and tRNA Arg mutations causing combined OXPHOS defects.

21 January 2018

1 reference

Mitochondrial tRNA 3' end metabolism and human disease.

21 January 2018

1 reference

Dimerization of a pathogenic human mitochondrial tRNA.

21 January 2018

1 reference

The mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode syndrome-associated human mitochondrial tRNALeu(UUR) mutation causes aminoacylation deficiency and concomitant reduced association of mRNA with ribosomes.

21 January 2018

1 reference

New mitochondrial tRNA HIS mutation in a family with lactic acidosis and stroke-like episodes (MELAS).

21 January 2018

1 reference

Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA(Lys) mutation

21 January 2018

1 reference

Impairment of mitochondrial tRNAIle processing by a novel mutation associated with chronic progressive external ophthalmoplegia

21 January 2018

1 reference

A novel mitochondrial tRNA(Ile) point mutation associated with chronic progressive external ophthalmoplegia and hyperCKemia

21 January 2018

1 reference

Complex neurologic syndrome associated with the G1606A mutation of mitochondrial DNA.

21 January 2018

1 reference

A disease-causing point mutation in human mitochondrial tRNAMet results in tRNA misfolding leading to defects in translational initiation and elongation

21 January 2018

1 reference

Leigh syndrome with cytochrome-c oxidase deficiency and a single T insertion nt 5537 in the mitochondrial tRNATrp gene

21 January 2018

1 reference

Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene

21 January 2018

1 reference

Crystal structure of human mitochondrial tyrosyl-tRNA synthetase reveals common and idiosyncratic features

21 January 2018

1 reference

Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation

21 January 2018

1 reference

Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome

21 January 2018

1 reference

A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α

21 January 2018

1 reference

Vaccinia and influenza A viruses select rather than adjust tRNAs to optimize translation.

21 January 2018

1 reference

Virus-induced transcriptional changes in the brain include the differential expression of genes associated with interferon, apoptosis, interleukin 17 receptor A, and glutamate signaling as well as flavivirus-specific upregulation of tRNA synthetases

21 January 2018

1 reference

Profiling non-lysyl tRNAs in HIV-1.

21 January 2018

1 reference

Translation matters: protein synthesis defects in inherited disease

21 January 2018

1 reference

Stressing out over tRNA cleavage

21 January 2018

1 reference

tRNA genes in eukaryotic genome organization and reorganization

31 March 2020

1 reference

Controlling gene expression in response to stress.

31 March 2020

1 reference

A mitochondrial tRNA anticodon swap associated with a muscle disease

31 March 2020

1 reference

Cytochrome c oxidase activity is deficient in blood vessels of patients with myoclonus epilepsy with ragged-red fibers

31 March 2020

1 reference

Role of tRNA modifications in human diseases

31 March 2020

1 reference

Multiple neonatal deaths due to a homoplasmic mitochondrial DNA mutation

31 March 2020

1 reference

Mitochondrial diabetes: investigation and identification of a novel mutation

31 March 2020

1 reference

A mitochondrial tRNA aspartate mutation causing isolated mitochondrial myopathy

31 March 2020

1 reference

Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25534324

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The optional E. coli prr locus encodes a latent form of phage T4-induced anticodon nuclease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25534324

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effect of growth rate on the amounts of ribosomal and transfer ribonucleic acids in yeast

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25534324