DNA methylation and demethylation as targets for antipsychotic therapy. (Q38264416)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364290 AND SRC:MED&resulttype=core&format=json

22 February 2020

review article

3 references

4 September 2020

25 January 2021

DNA methylation and demethylation as targets for antipsychotic therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364290 AND SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

4 September 2020

1 reference

4 September 2020

1 reference

25 January 2021

Alessandro Guidotti

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364290 AND SRC:MED&resulttype=core&format=json

22 February 2020

Dennis R Grayson

series ordinal

2

1 reference

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22 February 2020

publication date

1 September 2014

3 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364290 AND SRC:MED&resulttype=core&format=json

22 February 2020

4 September 2020

25 January 2021

Dialogues in Clinical Neuroscience

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364290 AND SRC:MED&resulttype=core&format=json

22 February 2020

25 January 2021

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364290 AND SRC:MED&resulttype=core&format=json

22 February 2020

issue

3

1 reference

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22 February 2020

page(s)

419-429

1 reference

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

22 February 2020

copyright license

2 references

4 September 2020

The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum.

25 January 2021

cites work

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TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

6 September 2017

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Promoter specific alterations of brain-derived neurotrophic factor mRNA in schizophrenia

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Neocortical RELN promoter methylation increases significantly after puberty

6 September 2017

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Glutamatergic deficits and parvalbumin-containing inhibitory neurons in the prefrontal cortex in schizophrenia

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Active DNA demethylation mediated by DNA glycosylases

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Epigenetic mechanisms in schizophrenia

6 September 2017

1 reference

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Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids

6 September 2017

1 reference

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An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes.

6 September 2017

1 reference

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The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

6 September 2017

1 reference

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

6 September 2017

1 reference

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Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis

6 September 2017

1 reference

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DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.

6 September 2017

1 reference

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The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes

6 September 2017

1 reference

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Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons

6 September 2017

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Epigenetics, DNA methylation, and chromatin modifying drugs

6 September 2017

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Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation

6 September 2017

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6 September 2017

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Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia

6 September 2017

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Epigenomic profiling reveals DNA-methylation changes associated with major psychosis

6 September 2017

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6 September 2017

1 reference

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Methylation status of the reelin promoter region in the brain of schizophrenic patients

6 September 2017

1 reference

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Neuroplasticity of neocortical circuits in schizophrenia.

6 September 2017

1 reference

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The pipeline and future of drug development in schizophrenia.

6 September 2017

1 reference

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Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars

6 September 2017

1 reference

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Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters

6 September 2017

1 reference

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Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder

6 September 2017

1 reference

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Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection.

6 September 2017

1 reference

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S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis

6 September 2017

1 reference

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Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood

6 September 2017

1 reference

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The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression

6 September 2017

1 reference

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Reelin promoter hypermethylation in schizophrenia

6 September 2017

1 reference

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DNA methylation and demethylation as targets for anticancer therapy

6 September 2017

1 reference

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GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon.

6 September 2017

1 reference

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Histone deacetylase inhibitors decrease reelin promoter methylation in vitro

6 September 2017

1 reference

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Cortical inhibitory neurons and schizophrenia

6 September 2017

1 reference

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6 September 2017

1 reference

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Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report

6 September 2017

1 reference

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In psychosis, cortical interneurons overexpress DNA-methyltransferase 1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures

6 September 2017

1 reference

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Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming

6 September 2017

1 reference

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Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder

6 September 2017

1 reference

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REELIN and schizophrenia: a disease at the interface of the genome and the epigenome

6 September 2017

1 reference

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DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability

6 September 2017

1 reference

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GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder

6 September 2017

1 reference

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Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression

6 September 2017

1 reference

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Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study

6 September 2017

1 reference

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A decrease of reelin expression as a putative vulnerability factor in schizophrenia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

The effects of antipsychotics on the turnover rate of GABA and acetylcholine in rat brain nuclei

6 September 2017

1 reference

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Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Analysis of the GAD1 promoter: Trans-acting factors and DNA methylation converge on the 5′ untranslated region

14 September 2017

1 reference

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Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

14 September 2017

1 reference

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Valproate induces replication-independent active DNA demethylation

14 September 2017

1 reference

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L-methionine decreases dendritic spine density in mouse frontal cortex

14 September 2017

1 reference

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Randomized, placebo-controlled pilot study of divalproex sodium in the treatment of acute exacerbations of chronic schizophrenia

27 September 2017

1 reference

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Functional and Anatomical Aspects of Prefrontal Pathology in Schizophrenia

27 September 2017

1 reference

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Neurotrophin regulation of cortical dendritic growth requires activity

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor.

23 June 2018

1 reference

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DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Methylation matters? Decreased methylation status of genomic DNA in the blood of schizophrenic twins

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Comparative gene expression study of the chronic exposure to clozapine and haloperidol in rat frontal cortex

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Valproate induces DNA demethylation in nuclear extracts from adult mouse brain

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Adjunct divalproex or lithium to clozapine in treatment-resistant schizophrenia

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Analysis of pyramidal neuron morphology in an inducible knockout of brain-derived neurotrophic factor

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Clozapine and the mitogen-activated protein kinase signal transduction pathway: implications for antipsychotic actions

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Gene expression in dopamine and GABA systems in an animal model of schizophrenia: effects of antipsychotic drugs

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214182

Induction of the reelin promoter by retinoic acid is mediated by Sp1

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25364290

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25364290

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364290 AND SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

25364290

1 reference