Posttranslational modifications of RUNX1 as potential anticancer targets (Q38255068)

1 September 2017

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title

Posttranslational modifications of RUNX1 as potential anticancer targets (English)

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1 September 2017

S Goyama

1

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1 September 2017

G Huang

series ordinal

2

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1 September 2017

M Kurokawa

series ordinal

3

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1 September 2017

J C Mulloy

series ordinal

4

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1 September 2017

language of work or name

English

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publication date

29 September 2014

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1 September 2017

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1 September 2017

volume

34

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1 September 2017

issue

27

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1 September 2017

page(s)

3483-3492

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Core binding factor at the crossroads: determining the fate of the HSC.

1 September 2017

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RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes

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AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations.

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The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region

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The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

21 January 2018

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Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal

21 January 2018

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Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis

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Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19ARF.

21 January 2018

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Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1

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A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis

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Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

21 January 2018

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Runx1 is essential at two stages of early murine B-cell development.

21 January 2018

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Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia

21 January 2018

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Interphase FISH on TEL/AML1 positive acute lymphoblastic leukemia relapses--analysis of clinical relevance of additional TEL and AML1 copy number changes

21 January 2018

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Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.

21 January 2018

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

21 January 2018

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NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.

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Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.

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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

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RUNX3 is multifunctional in carcinogenesis of multiple solid tumors

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A molecular signature of metastasis in primary solid tumors

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The RUNX family in breast cancer: relationships with estrogen signaling

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Comprehensive molecular portraits of human breast tumours

21 January 2018

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Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines

21 January 2018

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Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression

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Runx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin

21 January 2018

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Genome-wide catalogue of chromosomal aberrations in barrett's esophagus and esophageal adenocarcinoma: a high-density single nucleotide polymorphism array analysis.

21 January 2018

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Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis

21 January 2018

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Runx1 is a tumor suppressor gene in the mouse gastrointestinal tract.

21 January 2018

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Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-β-signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability

21 January 2018

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Phorbol ester treatment of K562 cells regulates the transcriptional activity of AML1c through phosphorylation

21 January 2018

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The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.305

AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.305

Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.305

Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.305

Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.305

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

Histone arginine methylation keeps RUNX1 target genes in an intermediate state

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription.

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

CHIP functions an E3 ubiquitin ligase of Runx1.

21 January 2018

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Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation.

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

Phosphorylation of AML1/RUNX1 regulates its degradation and nuclear matrix association

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

Tyrosyl phosphorylation toggles a Runx1 switch

21 January 2018

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RUNX1 Mutations in Acute Myeloid Leukemia: Results From a Comprehensive Genetic and Clinical Analysis From the AML Study Group

21 January 2018

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AML1/RUNX1 gene point mutations in childhood myeloid malignancies

21 January 2018

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Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia

21 January 2018

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In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis

21 January 2018

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RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

21 January 2018

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Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

Retinoic acid and arsenic trioxide for acute promyelocytic leukemia

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

PML targeting eradicates quiescent leukaemia-initiating cells

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.305

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

21 January 2018

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Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy

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Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult

31 March 2020

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Characterization of additional genetic events in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion: a molecular cytogenetics study

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Whole-genome analysis informs breast cancer response to aromatase inhibition

31 March 2020

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Clinical significance of runt-related transcription factor 1 polymorphism in prostate cancer

31 March 2020

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Functional domains of Runx1 are differentially required for CD4 repression, TCRbeta expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development

31 March 2020

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The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

31 March 2020

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12 December 2020

Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma.

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12 December 2020

Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis

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12 December 2020

Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias

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12 December 2020

Drugging the undruggable: transcription therapy for cancer

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12 December 2020

Identifiers

DOI

10.1038/ONC.2014.305

1 reference

Dimensions Publication ID

1 September 2017

1050626717

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1 reference