Understanding the CD28/CTLA-4 (CD152) pathway and its implications for costimulatory blockade (Q38237428)

31 August 2017

title

Understanding the CD28/CTLA-4 (CD152) pathway and its implications for costimulatory blockade (English)

1 reference

31 August 2017

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25098238 AND SRC:MED&resulttype=core&format=json

1 June 2020

author name string

D Gardner

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25098238 AND SRC:MED&resulttype=core&format=json

1 June 2020

L E Jeffery

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25098238 AND SRC:MED&resulttype=core&format=json

1 June 2020

language of work or name

English

0 references

publication date

6 August 2014

1 reference

American Journal of Transplantation

31 August 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25098238 AND SRC:MED&resulttype=core&format=json

1 June 2020

volume

14

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25098238 AND SRC:MED&resulttype=core&format=json

1 June 2020

issue

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25098238 AND SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

1985-1991

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25098238 AND SRC:MED&resulttype=core&format=json

The role of the CD28 receptor during T cell responses to antigen

1 June 2020

cites work

1 reference

CD28, CTLA-4 and their ligands: who does what and to whom?

21 January 2018

1 reference

The B7/CD28 costimulatory family in autoimmunity

21 January 2018

1 reference

What's the difference between CD80 and CD86?

21 January 2018

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B7-H2 Is a Costimulatory Ligand for CD28 in Human

21 January 2018

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Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses

21 January 2018

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Inflammatory signals in dendritic cell activation and the induction of adaptive immunity

21 January 2018

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The interaction properties of costimulatory molecules revisited.

21 January 2018

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Treg and CTLA-4: two intertwining pathways to immune tolerance

21 January 2018

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

1 reference

CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms

21 January 2018

1 reference

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

21 January 2018

1 reference

CTLA-4 ligation blocks CD28-dependent T cell activation

21 January 2018

1 reference

Molecular basis of T cell inactivation by CTLA-4

21 January 2018

1 reference

Reversal of the TCR stop signal by CTLA-4

21 January 2018

1 reference

The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes

21 January 2018

1 reference

Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.

21 January 2018

1 reference

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

21 January 2018

1 reference

Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation

21 January 2018

1 reference

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses

21 January 2018

1 reference

The reverse stop-signal model for CTLA4 function

21 January 2018

1 reference

Intrinsic and extrinsic control of peripheral T‐cell tolerance by costimulatory molecules of the CD28/ B7 family

21 January 2018

1 reference

Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.

21 January 2018

1 reference

CD4 regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

21 January 2018

1 reference

CTLA-4 control over Foxp3 regulatory T cell function

21 January 2018

1 reference

Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression

21 January 2018

1 reference

Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation

21 January 2018

1 reference

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

21 January 2018

1 reference

Constitutive clathrin-mediated endocytosis of CTLA-4 persists during T cell activation

21 January 2018

1 reference

Foxp3 natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

21 January 2018

1 reference

Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4 CD25 regulatory T-cell-mediated suppression

21 January 2018

1 reference

Regulatory T cells selectively control CD8 T cell effector pool size via IL-2 restriction

21 January 2018

1 reference

T-cell co-stimulatory blockade in transplantation: two steps forward one step back!

21 January 2018

1 reference

T-cell costimulatory blockade in organ transplantation

21 January 2018

1 reference

Longterm safety and efficacy of abatacept through 5 years of treatment in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor inhibitor therapy

21 January 2018

1 reference

A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression

21 January 2018

1 reference

Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.

21 January 2018

1 reference

Challenges and opportunities in targeting the costimulation pathway in solid organ transplantation

21 January 2018

1 reference

Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion

21 January 2018

1 reference

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

21 January 2018

1 reference

Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3 regulatory T cells

21 January 2018

1 reference

Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

21 January 2018

1 reference

A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study).

21 January 2018

1 reference

Costimulation blockade with belatacept in renal transplantation

21 January 2018

1 reference

CD28-specific immunomodulating antibodies: what can be learned from experimental models?

21 January 2018

1 reference

Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists

21 January 2018

1 reference

The effects of Foxp3-expressing regulatory T cells expanded with CD28 superagonist antibody in DSS-induced mice colitis

21 January 2018

1 reference

Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08.

21 January 2018

1 reference

Selective blockade of CD28 and not CTLA-4 with a single-chain Fv-alpha1-antitrypsin fusion antibody

21 January 2018

1 reference

Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation

21 January 2018

1 reference

Selective CD28 Blockade Attenuates Acute and Chronic Rejection of Murine Cardiac Allografts in a CTLA-4-Dependent Manner

21 January 2018

1 reference

2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8 T cell responses

21 January 2018

1 reference

Deleterious effect of CTLA4-Ig on a Treg-dependent transplant model

21 January 2018

1 reference

Preclinical efficacy and immunological safety of FR104, an antagonist anti-CD28 monovalent Fab' antibody

21 January 2018

1 reference