Thioredoxin-interacting protein: pathophysiology and emerging pharmacotherapeutics in cardiovascular disease and diabetes. (Q38236593)

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11 March 2020

title

Thioredoxin-interacting protein: pathophysiology and emerging pharmacotherapeutics in cardiovascular disease and diabetes (English)

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11 March 2020

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cardiovascular disease

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3

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11 March 2020

Aaron L Sverdlov

7

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11 March 2020

John D. Horowitz

9

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author name string

Cher-Rin Chong

1

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11 March 2020

Wai Ping A Chan

2

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11 March 2020

Saifei Liu

4

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11 March 2020

Nathan E K Procter

5

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11 March 2020

Doan T Ngo

6

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11 March 2020

Yuliy Y Chirkov

8

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11 March 2020

publication date

1 August 2014

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25088927 AND SRC:MED&resulttype=core&format=json

Cardiovascular Drugs and Therapy

11 March 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25088927 AND SRC:MED&resulttype=core&format=json

11 March 2020

volume

28

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issue

4

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page(s)

347-360

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Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance

11 March 2020

cites work

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The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange

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Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins.

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The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits

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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

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An expanded family of arrestins regulate metabolism

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Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function

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Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein

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Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein

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Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling

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TXNIP shuttling: missing link between oxidative stress and inflammasome activation

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Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome

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IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

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Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis

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Thioredoxin-interacting protein (Txnip) is a feedback regulator of S-nitrosylation

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Disulfide Bond-mediated multimerization of Ask1 and its reduction by thioredoxin-1 regulate H(2)O(2)-induced c-Jun NH(2)-terminal kinase activation and apoptosis

21 January 2018

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Catalytic degradation of vitamin D up-regulated protein 1 mRNA enhances cardiomyocyte survival and prevents left ventricular remodeling after myocardial ischemia

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The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation

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A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy

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Redox regulation by Nrf2: gatekeeping for the basal and diabetes-induced expression of thioredoxin interacting protein

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Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells

21 January 2018

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Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet

21 January 2018

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Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2

21 January 2018

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Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells

21 January 2018

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Thioredoxin-interacting protein is a biomechanical regulator of Src activity: key role in endothelial cell stress fiber formation

21 January 2018

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Vitamin D(3)-up-regulated protein-1 is a stress-responsive gene that regulates cardiomyocyte viability through interaction with thioredoxin

21 January 2018

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Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload

21 January 2018

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Overexpression of thioredoxin-binding protein 2 increases oxidation sensitivity and apoptosis in human lens epithelial cells

21 January 2018

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Mechanistic target of rapamycin (mTOR) dependent regulation of thioredoxin interacting protein (TXNIP) transcription in hypoxia

21 January 2018

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Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity

21 January 2018

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TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis

21 January 2018

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Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions

21 January 2018

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Nitric oxide-dependent suppression of thioredoxin-interacting protein expression enhances thioredoxin activity

21 January 2018

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Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets

21 January 2018

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Reciprocal regulation of NO signaling and TXNIP expression in humans: impact of aging and ramipril therapy

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21 January 2018

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Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression

21 January 2018

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Deficiency of thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes epithelial to mesenchymal transition

21 January 2018

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21 January 2018

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AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.

21 January 2018

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21 January 2018

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21 January 2018

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Thioredoxin-interacting protein suppresses bladder carcinogenesis

21 January 2018

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Targeting tumor angiogenesis with histone deacetylase inhibitors

21 January 2018

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Inhibition of Histone Deacetylase 10 Induces Thioredoxin-Interacting Protein and Causes Accumulation of Reactive Oxygen Species in SNU-620 Human Gastric Cancer Cells

21 January 2018

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Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis

21 January 2018

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Cyclic AMP signaling stimulates proteasome degradation of thioredoxin interacting protein (TxNIP) in pancreatic beta-cells

21 January 2018

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TXNIP regulates peripheral glucose metabolism in humans

21 January 2018

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Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein

21 January 2018

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A potential mechanism of metformin-mediated regulation of glucose homeostasis: inhibition of Thioredoxin-interacting protein (Txnip) gene expression.

21 January 2018

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Impaired tissue responsiveness to organic nitrates and nitric oxide: a new therapeutic frontier?

21 January 2018

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Vitamin D(2) supplementation induces the development of aortic stenosis in rabbits: interactions with endothelial function and thioredoxin-interacting protein.

21 January 2018

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Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations.

21 January 2018

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Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment

21 January 2018

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Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling

21 January 2018

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Preventing β-cell loss and diabetes with calcium channel blockers

21 January 2018

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5-Fluorouracil-induced coronary vasospasm

21 January 2018

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A case of severe coronary spasm associated with 5-fluorouracil chemotherapy

21 January 2018

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Rare sugar D-allose enhances anti-tumor effect of 5-fluorouracil on the human hepatocellular carcinoma cell line HuH-7.

21 January 2018

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The Emerging Role of Poly(ADP-Ribose) Polymerase Inhibitors in Cancer Treatment

21 January 2018

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Minocycline protects cardiac myocytes against simulated ischemia–reperfusion injury by inhibiting poly(ADP-ribose) polymerase-1.

21 January 2018

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The Nrf2 system as a potential target for the development of indirect antioxidants.

21 January 2018

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Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease

21 January 2018

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Amelioration of renal ischaemia-reperfusion injury by liposomal delivery of curcumin to renal tubular epithelial and antigen-presenting cells.

21 January 2018

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trans-Resveratrol downregulates Txnip overexpression occurring during liver ischemia-reperfusion.

21 January 2018

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Dual targeting of the antagonistic pathways mediated by Sirt1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions

21 January 2018

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The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.

21 January 2018

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The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML.

21 January 2018

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Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials

21 January 2018

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Angiotensin receptor blockers and risk of prostate cancer among United States veterans

21 January 2018

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Use of β-blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and risk of breast cancer recurrence: a Danish nationwide prospective cohort study

21 January 2018

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Angiotensin receptor blockers and risk of cancer: cohort study among people receiving antihypertensive drugs in UK General Practice Research Database

21 January 2018

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Calcium channel blockers act through nuclear factor Y to control transcription of key cardiac genes

21 January 2018

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10.1007/S10557-014-6538-5

21 January 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25088927 AND SRC:MED&resulttype=core&format=json

11 March 2020

1 reference