SMAD7: a timer of tumor progression targeting TGF-β signaling (Q38220764)

31 August 2017

title

SMAD7: a timer of tumor progression targeting TGF-β signaling (English)

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31 August 2017

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Lingyu Luo

1

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31 August 2017

Nianshuang Li

series ordinal

2

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31 August 2017

Nonghua Lv

series ordinal

3

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31 August 2017

Deqiang Huang

series ordinal

4

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31 August 2017

publication date

17 June 2014

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31 August 2017

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31 August 2017

volume

35

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31 August 2017

issue

9

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31 August 2017

page(s)

8379-8385

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Differential expression of transforming growth factor-beta receptors I and II and activation of Smad 3 in keloid fibroblasts

31 August 2017

cites work

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Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis

21 January 2018

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TGF-beta signaling and the fibrotic response

21 January 2018

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Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation

21 January 2018

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TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

21 January 2018

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Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition

21 January 2018

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Regulatory networks defining EMT during cancer initiation and progression

21 January 2018

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https://api.crossref.org/works/10.1007/S13277-014-2203-7

Epithelial-mesenchymal transition (EMT) induced by TNF-α requires AKT/GSK-3β-mediated stabilization of snail in colorectal cancer

21 January 2018

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https://api.crossref.org/works/10.1007/S13277-014-2203-7

Beyond TGFβ: roles of other TGFβ superfamily members in cancer

21 January 2018

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Roles of TGFβ signaling Smads in squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer

21 January 2018

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TGFβ and BMP-2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway

21 January 2018

1 reference

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A crosstalk between the Smad and JNK signaling in the TGF-β-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Transforming growth factor-beta-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

TGFbeta1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Transforming growth factor β in cancer: Janus, the two-faced god.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Snail and Slug, key regulators of TGF-β-induced EMT, are sufficient for the induction of single-cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Clusterin mediates TGF-β-induced epithelial-mesenchymal transition and metastasis via Twist1 in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Expression of HMGA2 in bladder cancer and its association with epithelial-to-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor beta signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

TGF-β-induced epithelial-mesenchymal transition: a link between cancer and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

The Smad family and its role in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear str

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Yin Yang 1 (YY1) synergizes with Smad7 to inhibit TGF-β signaling in the nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Determinants of specificity in TGF-beta signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Signaling inputs converge on nuclear effectors in TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Regulation of TGF-beta family signaling by E3 ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

CD109-mediated degradation of TGF-β receptors and inhibition of TGF-β responses involve regulation of SMAD7 and Smurf2 localization and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

TGFbeta induces SIK to negatively regulate type I receptor kinase signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

The Deubiquitinase CYLD Targets Smad7 Protein to Regulate Transforming Growth Factor β (TGF-β) Signaling and the Development of Regulatory T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Overexpression of Smad proteins, especially Smad7, in oral epithelial dysplasias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

MiR-181c modulates the proliferation, migration, and invasion of neuroblastoma cells by targeting Smad7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Oncomirs - microRNAs with a role in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Smad4/Smad7 balance: a role of tumorigenesis in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

A study of Smad4, Smad6 and Smad7 in Surgically Resected Samples of Pancreatic Ductal Adenocarcinoma and Their Correlation with Clinicopathological Parameters and Patient Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Regulation of TGF-beta signaling by Smad7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

TGF-β: duality of function between tumor prevention and carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

The Smad7-Skp2 complex orchestrates Myc stability, impacting on the cytostatic effect of TGF-β

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Activation of extracellular signal-regulated kinase by TGF-beta1 via TbetaRII and Smad7 dependent mechanisms in human bronchial epithelial BEP2D cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Nuclear Smad7 Overexpressed in Mesenchymal Cells Acts as a Transcriptional Corepressor by Interacting with HDAC-1 and E2F to Regulate Cell Cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

The dual role of Smad7 in the control of cancer growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

MTA1-mediated transcriptional repression of SMAD7 in breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Increased risk of colon cancer associated with a genetic polymorphism of SMAD7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

The role of epithelial mesenchymal transition markers in thyroid carcinoma progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Stable Overexpression of Smad7 in Human Melanoma Cells Impairs Bone Metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Smad7 induces hepatic metastasis in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Smad7 antisense oligonucleotide-based therapy for inflammatory bowel diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S13277-014-2203-7

Transforming growth factor-beta 1 (TGF-beta 1) and TGF-beta 1 receptors in normal, cirrhotic, and neoplastic human livers

21 January 2018

1 reference

12 December 2020

TGF-beta signaling in cancer--a double-edged sword

1 reference

12 December 2020

Expression of Smad7 in cholangiocarcinoma: prognostic significance and implications for tumor metastasis

1 reference

12 December 2020

Prognostic implications for high expression of MiR-25 in lung adenocarcinomas of female non-smokers

1 reference

12 December 2020

Hypoxic conversion of SMAD7 function from an inhibitor into a promoter of cell invasion

1 reference

12 December 2020

Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling

1 reference

12 December 2020

IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses.

1 reference

12 December 2020

Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma

1 reference

12 December 2020

Differential effect of the expression of TGF-β pathway inhibitors, Smad-7 and Ski, on invasive breast carcinomas: relation to biologic behavior

1 reference

12 December 2020

10.1007/S13277-014-2203-7

Identifiers

DOI

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Dimensions Publication ID

31 August 2017

1019973074

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