Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies (Q38218536)

31 August 2017

title

Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies (English)

1 reference

31 August 2017

3

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7 June 2020

author name string

Y Aye

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909171 AND SRC:MED&resulttype=core&format=json

7 June 2020

M Li

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909171 AND SRC:MED&resulttype=core&format=json

7 June 2020

R S Weiss

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909171 AND SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

English

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publication date

9 June 2014

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31 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909171 AND SRC:MED&resulttype=core&format=json

7 June 2020

volume

34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909171 AND SRC:MED&resulttype=core&format=json

7 June 2020

issue

16

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909171 AND SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

2011-2021

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909171 AND SRC:MED&resulttype=core&format=json

DNA precursor metabolism and genomic stability

7 June 2020

cites work

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Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing

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Replication fork movement sets chromatin loop size and origin choice in mammalian cells

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Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

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Interactions between deoxyribonucleotide and DNA synthesis

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Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

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Replication stress links structural and numerical cancer chromosomal instability

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Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase

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Class I ribonucleotide reductases: metallocofactor assembly and repair in vitro and in vivo.

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Structure of ribonucleotide reductase protein R1

21 January 2018

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Reversible, long-range radical transfer in E. coli class Ia ribonucleotide reductase

21 January 2018

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Uncoupling of allosteric and oligomeric regulation in a functional hybrid enzyme constructed from Escherichia coli and human ribonucleotide reductase.

21 January 2018

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Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

21 January 2018

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Clofarabine 5′-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit

21 January 2018

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Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers

21 January 2018

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Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: refinements and consequences

21 January 2018

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Thioredoxins and glutaredoxins: unifying elements in redox biology

21 January 2018

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

21 January 2018

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Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis

21 January 2018

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Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair

21 January 2018

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Ribonucleotide reductases

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.155

Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Ribonucleotide reductase association with mammalian liver mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Mitochondrial neurogastrointestinal encephalopathy due to mutations in RRM2B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

A heterozygous truncating mutation in RRM2B causes autosomal-dominant progressive external ophthalmoplegia with multiple mtDNA deletions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

DNA building blocks: keeping control of manufacture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Controlled protein degradation regulates ribonucleotide reductase activity in proliferating mammalian cells during the normal cell cycle and in response to DNA damage and replication blocks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Two YY-1-binding proximal elements regulate the promoter strength of the TATA-less mouse ribonucleotide reductase R1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F-binding site and an upstream promoter activating region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2014.155

DNA damage and cell cycle regulation of ribonucleotide reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Induction of the mouse ribonucleotide reductase R1 and R2 genes in response to DNA damage by UV light

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

A ribonucleotide reductase gene is a transcriptional target of p53 and p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Break-induced ATR and Ddb1-Cul4(Cdt)² ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Activity of ribonucleotide reductase helps determine how cells repair DNA double strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate pools

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Molecular cloning of the cDNA for a mutant mouse ribonucleotide reductase M1 that produces a dominant mutator phenotype in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Overproduction of the free radical of ribonucleotide reductase in hydroxyurea-resistant mouse fibroblast 3T6 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Hypermutability and error catastrophe due to defects in ribonucleotide reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Ribonucleotide reductase M2 subunit is a novel diagnostic marker and a potential therapeutic target in bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Emerging roles of the ribonucleotide reductase M2 in colorectal cancer and ultraviolet-induced DNA damage repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Gene expression profiles of human breast cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

p53R2 is a prognostic factor of melanoma and regulates proliferation and chemosensitivity of melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Ribonucleotide reductase small subunit p53R2 promotes oral cancer invasion via the E-cadherin/beta-catenin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Expression of p53R2 is related to prognosis in patients with esophageal squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Gene aberrations of RRM1 and RRM2B and outcome of advanced breast cancer after treatment with docetaxel with or without gemcitabine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

RRM1-induced metastasis suppression through PTEN-regulated pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Suppression of lung tumor formation by the regulatory subunit of ribonucleotide reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

RRM1 expression and clinical outcome of gemcitabine-containing chemotherapy for advanced non-small-cell lung cancer: A meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Randomized phase III trial of gemcitabine-based chemotherapy with in situ RRM1 and ERCC1 protein levels for response prediction in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Response to first-line chemotherapy in patients with non-small cell lung cancer according to RRM1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Clinical efficacy and predictive molecular markers of neoadjuvant gemcitabine and pemetrexed in resectable non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Increased expression of the large subunit of ribonucleotide reductase is involved in resistance to gemcitabine in human mammary adenocarcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Feasibility and efficacy of molecular analysis-directed individualized therapy in advanced non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Ribonucleotide reductase small subunit p53R2 facilitates p21 induction of G1 arrest under UV irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Metastasis-suppressing potential of ribonucleotide reductase small subunit p53R2 in human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Ribonucleotide Reductase Small Subunit M2B Prognoses Better Survival in Colorectal Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

A molecular view on signal transduction by the apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Silencing of the p53R2 gene by RNA interference inhibits growth and enhances 5-fluorouracil sensitivity of oral cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Upregulation of the p53R2 ribonucleotide reductase subunit by nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Expression of nucleoside transporters, deoxycitidine kinase, ribonucleotide reductase regulatory subunits, and gemcitabine catabolic enzymes in primary ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Ribonucleotide reductase subunit M2 mRNA expression in pretreatment biopsies obtained from unresectable pancreatic carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Sensitizing cancer cells: is it really all about U?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

The DNA damage response: putting checkpoints in perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Ribonucleotide reductase inhibitors and future drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Ribonucleotide reductase inhibitors: new strategies for cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Gemcitabine in non-small cell lung cancer (NSCLC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Discovery and development of clofarabine: a nucleoside analogue for treating cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Fludarabine phosphate for the first-line treatment of chronic lymphocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Beyond hairy cell: the activity of cladribine in other hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Enzymatically active mammalian ribonucleotide reductase exists primarily as an alpha6beta2 octamer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Nucleic acids as therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Combination therapy with gemcitabine and carboplatin in recurrent ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Treatment of normal and malignant cells with nucleoside analogues and etoposide enhances deoxycytidine kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Altered expression of ribonucleotide reductase and role of M2 gene amplification in hydroxyurea-resistant hamster, mouse, rat, and human cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Elevated expression of M1 and M2 components and drug-induced posttranscriptional modulation of ribonucleotide reductase in a hydroxyurea-resistant mouse cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Reduced forms of the iron-containing small subunit of ribonucleotide reductase from Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

RNA interference targeting the R2 subunit of ribonucleotide reductase inhibits growth of tumor cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Silencing of ribonucleotide reductase subunit M1 potentiates the antitumor activity of gemcitabine in resistant cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

siRNA delivery systems for cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Drug delivery of siRNA therapeutics: potentials and limits of nanosystems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.155

Systemic delivery of siRNA nanoparticles targeting RRM2 suppresses head and neck tumor growth.

21 January 2018

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Retrovirally mediated RNA interference targeting the M2 subunit of ribonucleotide reductase: A novel therapeutic strategy in pancreatic cancer

21 January 2018

1 reference

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ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine

21 January 2018

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N-Hydroxyurea—A versatile zinc binding function in the design of metalloenzyme inhibitors

21 January 2018

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A novel homozygous RRM2B missense mutation in association with severe mtDNA depletion

21 January 2018

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Localization of ribonucleotide reductase in mammalian cells

31 March 2020

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Association of RRM1 –37A>C polymorphism with clinical outcome in colorectal cancer patients treated with gemcitabine-based chemotherapy

31 March 2020

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An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma

31 March 2020

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The predictive value of p53, p53R2, and p21 for the effect of chemoradiation therapy on oesophageal squamous cell carcinoma

31 March 2020

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Protein Radicals in Enzyme Catalysis

31 March 2020

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Ribonucleotide reductases: radical enzymes with suicidal tendencies

31 March 2020

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2-fluoro-ATP: a toxic metabolite of 9-beta-D-arabinosyl-2-fluoroadenine

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Activation of deoxycytidine kinase by various nucleoside analogues.

31 March 2020

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A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems

31 March 2020

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Reduction and loss of the iron center in the reaction of the small subunit of mouse ribonucleotide reductase with hydroxyurea

31 March 2020

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Phase II study of 3-AP Triapine in patients with recurrent or metastatic head and neck squamous cell carcinoma

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Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones

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Severe autoimmune hemolytic anemia in eight patients treated with fludarabine.

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12 December 2020

p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint

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Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311.

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Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase

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Alterations in deoxyribonucleotide metabolism in cultured cells with ribonucleotide reductase activities refractory to feedback inhibition by 2'-deoxyadenosine triphosphate.

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12 December 2020

The mammalian ribonucleotide reductase R2 component cooperates with a variety of oncogenes in mechanisms of cellular transformation

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GTI-2040, an antisense agent targeting the small subunit component (R2) of human ribonucleotide reductase, shows potent antitumor activity against a variety of tumors.

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Differential extension of 3' mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-alpha

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The place of hydroxyurea in the treatment of primary brain tumors

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Reactive oxygen species in tumorigenesis.

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12 December 2020

P53R2, p53 inducible ribonucleotide reductase gene, correlated with tumor progression of non-small cell lung cancer.

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12 December 2020

Alterations in the activity and regulation of mammalian ribonucleotide reductase by chlorambucil, a DNA damaging agent

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12 December 2020

The effects of dNTP pool imbalances on frameshift fidelity during DNA replication

1 reference

12 December 2020

Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous cell carcinoma

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12 December 2020

Immunocytochemical evidence for the cytoplasmic localization and differential expression during the cell cycle of the M1 and M2 subunits of mammalian ribonucleotide reductase

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12 December 2020

Saturation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate accumulation in leukemia cells during high-dose 1-beta-D-arabinofuranosylcytosine therapy

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12 December 2020

Ribonucleotide reductase subunit M1 is a possible chemoresistance marker to gemcitabine in biliary tract carcinoma

1 reference

12 December 2020

Long-term follow-up of patients with hairy cell leukemia after cladribine treatment

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12 December 2020

Cell cycle-dependent regulation of mammalian ribonucleotide reductase. The S phase-correlated increase in subunit M2 is regulated by de novo protein synthesis

1 reference

12 December 2020

Gemcitabine: single-agent and combination therapy in non-small cell lung cancer

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12 December 2020

Acute myeloid leukemia and myelodysplastic syndromes following essential thrombocythemia treated with hydroxyurea: high proportion of cases with 17p deletion

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12 December 2020

Ribonucleotide reductase and cell proliferation. I. Variations of ribonucleotide reductase activity with tumor growth rate in a series of rat hepatomas.

1 reference

12 December 2020

Randomized comparison of busulfan and hydroxyurea in chronic myelogenous leukemia: prolongation of survival by hydroxyurea. The German CML Study Group.

1 reference

12 December 2020

Overexpression of catalytic subunit M2 in patients with ovarian cancer.

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12 December 2020

Characterization of the free radical of mammalian ribonucleotide reductase

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12 December 2020

Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits

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12 December 2020

Formation of deoxycytidine phosphates from cytidine phosphates in extracts from Escherichia coli

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12 December 2020