Mechanistic explanation for platelet contribution to cancer metastasis (Q38214959)

31 August 2017

title

Mechanistic explanation for platelet contribution to cancer metastasis (English)

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31 August 2017

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1

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31 August 2017

Sebastian Dütting

2

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31 August 2017

Bernhard Nieswandt

series ordinal

3

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31 August 2017

publication date

1 May 2014

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31 August 2017

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31 August 2017

volume

133 Suppl 2

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31 August 2017

page(s)

S149-57

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Microenvironmental regulation of metastasis

31 August 2017

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Platelets and cancer metastasis: a causal relationship?

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7 January 2021

Preoperative platelet count associates with survival and distant metastasis in surgically resected colorectal cancer patients

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7 January 2021

Platelet receptor signaling in thrombus formation

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Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo

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The Hallmarks of Cancer

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Increased thromboxane A2 production at primary tumor site in metastasizing squamous cell carcinoma of the larynx

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7 January 2021

Pulmonary microembolism

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7 January 2021

Platelet Activation and Fibrinolysis in Large Bowel Cancer

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7 January 2021

beta-Thromboglobulin in patients with breast cancer

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7 January 2021

Abnormal haemostasis in small cell lung cancer

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7 January 2021

Platelet activation and platelet lipid composition in pulmonary cancer

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7 January 2021

Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo

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7 January 2021

Platelet GPVI: a target for antithrombotic therapy?!

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7 January 2021

Tumor-cell-induced platelet aggregation is a glycoprotein-dependent and lipoxygenase-associated process

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7 January 2021

Inhibition of human tumor cell induced platelet aggregation by antibodies to platelet glycoproteins Ib and IIb/IIIa

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7 January 2021

Inhibition of platelet GPIb alpha and promotion of melanoma metastasis

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7 January 2021

Platelet glycoprotein Ib alpha supports experimental lung metastasis

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7 January 2021

Role of von Willebrand factor in tumor metastasis

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7 January 2021

Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice

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7 January 2021

P-selectin deficiency attenuates tumor growth and metastasis

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7 January 2021

Endothelial P-selectin as a target of heparin action in experimental melanoma lung metastasis.

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7 January 2021

Platelets and P-selectin control tumor cell metastasis in an organ-specific manner and independently of NK cells

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7 January 2021

Platelets: linking hemostasis and cancer

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7 January 2021

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

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7 January 2021

Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.

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7 January 2021

The impact of Aggrus/podoplanin on platelet aggregation and tumour metastasis

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7 January 2021

Enhanced expression of Aggrus (T1alpha/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma.

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7 January 2021

Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregation-stimulating domain

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7 January 2021

Prevention of hematogenous metastasis by neutralizing mice and its chimeric anti-Aggrus/podoplanin antibodies

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7 January 2021

The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis

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7 January 2021

Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.

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7 January 2021

T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema

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7 January 2021

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation.

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7 January 2021

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

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7 January 2021

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.

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7 January 2021

The role of ADP receptors in platelet function

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7 January 2021

Human melanoma cell lines differ in their capacity to release ADP and aggregate platelets

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7 January 2021

Platelet P2Y12 is involved in murine pulmonary metastasis

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7 January 2021

Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor.

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7 January 2021

Malignant melanoma. Interaction with coagulation and fibrinolysis pathways in situ

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7 January 2021

Expression of tissue factor correlates with grade of malignancy in human glioma.

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7 January 2021

Expression of tissue factor in non-small-cell lung cancers and its relationship to metastasis

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7 January 2021

Tissue factor expression in human colorectal carcinoma: correlation with hepatic metastasis and impact on prognosis

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7 January 2021

Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis

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7 January 2021

Role of thrombin signalling in platelets in haemostasis and thrombosis

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7 January 2021

Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.

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7 January 2021

Integrins in platelet activation

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7 January 2021

A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Antimetastatic effects of synthetic polypeptides containing repeated structures of the cell adhesive Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) sequences

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454.

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Platelet and osteoclast β 3 integrins are critical for bone metastasis

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Differing platelet aggregating effects by two tumor cell lines: Absence of role for platelet‐derived ADP

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic acid allogeneic tumors. I. Distribution of reactivity and specificity

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Targeting natural killer cells and natural killer T cells in cancer

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Role of NK cells in tumour growth and metastasis in beige mice

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Only severe thrombocytopenia results in bleeding and defective thrombus formation in mice.

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Platelet-derived transforming growth factor-beta down-regulates NKG2D thereby inhibiting natural killer cell antitumor reactivity

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Platelet-derived MHC class I confers a pseudonormal phenotype to cancer cells that subverts the antitumor reactivity of natural killer immune cells

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Cancer immunotherapy via dendritic cells

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7 January 2021

Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

VEGF as a mediator of tumor-associated immunodeficiency

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Platelet number and interleukin-6 correlate with VEGF but not with bFGF serum levels of advanced cancer patients.

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Tumor-host immune interactions and dendritic cell dysfunction

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Platelet-mimicry of cancer cells: epiphenomenon with clinical significance

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Stepping out of the flow: capillary extravasation in cancer metastasis

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions

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7 January 2021

Platelet functions beyond hemostasis

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7 January 2021

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

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7 January 2021

Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts

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7 January 2021

Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis

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7 January 2021

Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules

1 reference

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7 January 2021

Regulation of cerebromicrovascular permeability by lysophosphatidic acid

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7 January 2021

Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells

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7 January 2021

Matrix metalloproteinases and tumor metastasis

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice.

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7 January 2021

Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice

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7 January 2021

Platelet secretory mechanisms

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7 January 2021

The platelet release reaction: just when you thought platelet secretion was simple

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7 January 2021

Recent advances in understanding serotonin regulation of cardiovascular function

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7 January 2021

The importance of 5-HT for tumor cell lodgement in the liver

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7 January 2021

The role of calcium channels and serotonin (5-HT2) receptors for tumour cell lodgement in the liver

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Histamine receptors and cancer pharmacology

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Cancer cell adhesion and metastasis: selectins, integrins, and the inhibitory potential of heparins

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E.

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion molecules

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Macrophage diversity enhances tumor progression and metastasis

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7 January 2021

Tumor angiogenesis: therapeutic implications

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7 January 2021

Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Evidence that platelets promote tube formation by endothelial cells on matrigel.

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7 January 2021

The functional role of blood platelet components in angiogenesis

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7 January 2021

Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released

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7 January 2021

Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response.

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

What is natural in natural killer cells?

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7 January 2021

Natural killer cell-directed therapies: moving from unexpected results to successful strategies

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7 January 2021

Scientific and therapeutic advances in antiplatelet therapy

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment.

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

A cohort study investigating aspirin use and survival in men with prostate cancer

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Aspirin use after diagnosis improves survival in older adults with colon cancer: a retrospective cohort study

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: a PLCO study

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Use of aspirin, but not other non-steroidal anti-inflammatory drugs is associated with decreased prostate cancer risk at the population level

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

The role of aspirin in cancer prevention

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https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Coagulation and metastasis: what does the experimental literature tell us?

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Platelet glycoprotein VI facilitates experimental lung metastasis in syngenic mouse models

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Deadly allies: the fatal interplay between platelets and metastasizing cancer cells

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Heparin attenuates metastasis mainly due to inhibition of P- and L-selectin, but non-anticoagulant heparins can have additional effects

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Warfarin for cancer prevention

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

Clinical studies with anticoagulants to improve survival in cancer patients

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

A platelet-mimetic paradigm for metastasis-targeted nanomedicine platforms

1 reference

https://api.crossref.org/works/10.1016/S0049-3848(14)50025-4

7 January 2021

10.1016/S0049-3848(14)50025-4

Identifiers

DOI

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31 August 2017

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